Jefferson Scientists Devise Way To Treat Animals Chronically Infected With Hepatitis B

Scientists at Jefferson Medical College may have helped devise a new way to fight the hepatitis B virus (HBV). Timothy Block, Ph.D., professor of biochemistry and molecular pharmacology and medicine at Thomas Jefferson University in Philadelphia, and his colleagues at several institutions have found that by interfering with a specific step in the life cycle of the woodchuck hepatitis virus, the virus can't reproduce, shutting down its ability to infect a cell.

By blocking the creation of a virus "envelope", the virus DNA is locked within the infected cell. As a result, levels of the virus in the animals' bloodstream drop dramatically. The researchers say that the work may provide leads to improved methods of fighting hepatitis B virus (HBV) and hepatitis C (HCV) infections in chronically infected humans.

"This points to a new way to inhibit the hepatitis B virus," says Dr. Block, who is a member of Jefferson's Kimmel Cancer Center and director of the Jefferson Center for Biomedical Research and Agricultural Medicine. Dr. Block and his colleagues report their results in May in the journal Nature Medicine.

"We've discovered that a very specific step in the life cycle of the virus that can be selectively inhibited by a drug, N-nonyl-DNJ," he explains. "It works by inhibiting the first step in the glycosylation process that all cell glycoproteins go through to reproduce and be able to infect. We discovered that the host cellular glycoproteins appear to be far less sensitive to this inhibition than is HBV.

"We were able to inhibit this step in glyco-processing and shut down the appearance of infectious virus in most of the infected animals," he says. "It prevents the appearance of envelope virus in the animals' blood, so it prevents infection.

"This paper introduces another way of inhibiting HBV," he says. "The other ways to inh

Contact: Steve Benowitz
Thomas Jefferson University

Page: 1 2 3

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists use gene repair technique to change albino mice hairs to black
11. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: