HOME >> BIOLOGY >> NEWS
Jefferson Scientists Find Further Proof Of Damage To The FHIT Gene In Breast Cancers

Scientists at Thomas Jefferson University in Philadelphia, the University Hospital of Iceland in Reykjavik, and the National Human Genome Research Institute in Bethesda have found further evidence linking damage to the tumor suppressor gene FHIT to the development of breast cancer.

In a study of 92 Icelandic women, the researchers, led by Kay Huebner, Ph.D., professor of microbiology and immunology at Jefferson Medical College and a member of Jefferson's Kimmel Cancer Center, showed reduced levels of Fhit, the protein for which FHIT encodes, both in women with sporadic breast cancer and those with hereditary breast cancer who carry a BRCA2 mutation, a gene predisposing them to develop the disease. Among the 58 sporadic and 34 BRCA2-associated breast cancers, Dr. Huebner's team reports a "significant association" between damage to the FHIT gene at its most fragile area and a reduced expression of the Fhit protein.

She reports her team's work April 13 at the American Association for Cancer Research meeting in Philadelphia.

"Genetic alterations at this most common fragile site in the FHIT gene lead to reduced Fhit protein expression in sporadic cancers and in a much larger fraction of BRCA2-associated familial cancer," Dr. Huebner explains. "This is consistent with the idea that loss of BRCA2 function affects the stability of the FHIT site."

An improved understanding of the FHIT gene may lead to the identification of individuals predisposed to some of the most common human cancers, the development of new drugs that may arrest the growth of cancer cells, and prevention of some of the most common cancers.

In 1996, Dr. Huebner and Carlo M. Croce, M.D., director of the Kimmel Cancer Center, and professor and chair of microbiology and immunology at Jefferson Medical College, identified and characterized FHIT . The investigators found that the FHIT gene is located in the human genome's most fragile area, on human c
'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
215-955-5291
Thomas Jefferson University
13-Apr-1999


Page: 1 2 3

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists use gene repair technique to change albino mice hairs to black
11. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass ... is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory ... at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & ...
(Date:7/1/2020)... N.J. (PRWEB) , ... July 01, 2020 , ... ... announced that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in ... the company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot ...
(Date:6/25/2020)... MANSFIELD, Mass. (PRWEB) , ... June 24, 2020 ... ... provider of cloud-based enterprise software and software-driven clinical data services that accelerate drug ... trials for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands ... , Known as MediVet Biologics since its formation in 2016, the company is ... Animal Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, ... have entered into a strategic partnership whereby Catalent will provide support for the ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter ... great surgery is only the beginning of a successful study, while protecting and accessing ... Brad Gien, Global Head of Surgery from Envigo in a live ...
Breaking Biology Technology:
Cached News: