Jefferson Scientists Find Link Between Learning And Preventing Alzheimer's

A new study suggests that a stimulating, learning environment early in life might actually help ward off neurodegenerative diseases later. The findings indicate that nurture may be more influential than nature when it comes to the brain's resilience against injury.

Researchers at Jefferson Medical College of Thomas Jefferson University in Philadelphia and at the University of Auckland in New Zealand found that rats living in a stimulating environment filled with running wheels, tunnels, balls and food had 45 percent less brain cell death commonly associated with normal development and aging than rats living in basic surroundings. What's more, the stimulated rats exposed to a neurotoxin were nearly completely protected from brain cell loss, unlike those in a normal environment. The scientists report their results in April in the journal Nature Medicine.

"We were hoping to get some scientific underpinnings to the age-old maxim, 'use it or lose it,'" explains neuroscientist Matthew During, M.D., director the Central Nervous System Gene Therapy Center at Jefferson and professor of neurosurgery at Jefferson Medical College. He and his colleagues wanted to see if an enriched learning environment would result in any protective effect on the brain.

Dr. During was surprised how robust the enriched rat brains were. "We showed in this study that an enriched environment switched on genes in the brain, and we believe by that mechanism the brain becomes super-resilient, resistant to aging and diseases, such as Alzheimer's, Parkinson's, and traumatic brain injury," he says.

"There haven't been many careful studies done in the lab to show if actively using your brain enhances your ability to stay healthy, and what mechanisms might be involved in protecting the brain," he says. "We asked what that [stimulating environment] would do to cognitive function, particularly in preventing brain cell death and symptoms of Alzheim

Contact: Steve Benowitz
Thomas Jefferson University

Page: 1 2

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists use gene repair technique to change albino mice hairs to black
11. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: