HOME >> BIOLOGY >> NEWS
Jefferson Scientists Hopeful That Understanding Tumor-Suppressor Protein Function May Someday Lead To Treatment

Scientists at Jefferson Medical College of Thomas Jefferson University in Philadelphia appear to have an important clue to the workings of a gene that normally protects against cancer. Ultimately, by understanding how both the normal and the damaged gene work, scientists may be able to find ways to interfere with the development of cancer.

Charles Brenner, Ph.D., assistant professor of microbiology and immunology, and a member of Jefferson's Kimmel Cancer Center, and his colleagues at the University of Texas in San Antonio, and at the University of Sheffield in England, have distinguished between potential mechanisms by which the FHIT gene works in preventing cancer development.

A report of the researchers' work appears May 12 in the Proceedings of the National Academy of Sciences.

Dr. Brenner and his colleagues used a combined genetic, biochemical and crystallographic approach to gain information about the function of the tumor-suppressor protein, Fhit, the product of the FHIT gene.

According to Dr. Brenner, Fhit is "encoded in the most fragile site of the human genome. The FHIT gene is frequently inactivated early in the development of cancer, especially in lung cancer."

Dr. Brenner and his co-workers sought to understand how the Fhit protein suppresses tumor formation. "We knew that the Fhit protein is an enzyme that binds and cleaves an unusual class of nucleotides in the cell, called ApppA," he explains. "We wanted to determine if the important function of Fhit was to cleave ApppA or signal the presence of this compound in the cell in order to put the brakes on cell growth." Tumors form when the Fhit protein is absent.

New experiments showed that altered forms of the Fhit protein that bind but don't cleave ApppA are actually still working in tumor suppression. "That excluded the idea that the important thing that Fhit
'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
215-955-6300
Thomas Jefferson University
11-May-1998


Page: 1 2

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists use gene repair technique to change albino mice hairs to black
11. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/3/2018)... ... November 01, 2018 , ... The Conference ... be held February 6-8, 2019 at the Crowne Plaza Times Square in New ... plenary session is Genentech’s Global Franchise Leader in Cancer Immunotherapy Biomarkers and IO360° ...
(Date:11/3/2018)... ... 01, 2018 , ... Dr. Bryan Choi, a postdoctoral fellow in the ... School, has been awarded the 2018 xCELLigence Immunotherapy Research Grant by ACEA Biosciences ... a promising form of treatment designed to harness a patient’s own immune system to ...
(Date:10/31/2018)... ... October 30, 2018 , ... Azzur ... Operations. With more than 20 years of antibody purification and management experience, Heidinger ... industry. Heidinger joins Azzur from ImmunoReagents, a company he co-founded and managed for ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... POWAY, Calif. (PRWEB) , ... November 13, 2018 , ... ... to patients on the island of Kauai. Dr. Leadbeater, of Kahala ... cell services since 2009. Recently, he began traveling to the island of Kauai ...
(Date:11/13/2018)... ... November 12, 2018 , ... AseptiScope(TM), Inc. announces it ... U.S. studies, published last week, confirm pose a significant health risk. The ... conclude that stethoscopes are often improperly or rarely disinfected. In the AJIC November ...
(Date:11/13/2018)... ... November 12, 2018 , ... Dr. Dan Myers, a ... Springs, now welcomes new patients for MTM® Clear Aligners. Offering a variety of ... braces in the Sandy Springs and Alpharetta areas. Constantly on the forefront of ...
(Date:11/13/2018)... ... November 13, 2018 , ... Aditya Humad, Managing ... last week that asserts it is still trending upward with growing valuations based ... analysis describes market consolidation, pricing pressure and increased competition as reasons often cited ...
Breaking Biology Technology:
Cached News: