HOME >> BIOLOGY >> NEWS
Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue

MicroRNAs (miRNAs), tiny pieces of genetic material that can serve as stop signs for gene expression and protein synthesis, are thought to be important in the development of cancer. Now, researchers at Jefferson Medical College and the Kimmel Cancer Center of Thomas Jefferson University in Philadelphia have developed a technique that allows them to find which miRNA genes are expressed and how in both cancerous and normal tissue.

Scientists, led by Carlo Croce, M.D., director of Jefferson's Kimmel Cancer Center and professor of microbiology and immunology at Jefferson Medical College, have developed a microarray chip onto which they were able to put all the known miRNA genes in both human and mouse. They found that each tissue they tested had its own characteristic pattern of miRNA gene expression.

The work might enable scientists to gain a better understanding of the roles of miRNAs in cancer and provide targets for future drug development. They reported their findings June 21, 2004 online in the Proceedings of the National Academy of Sciences.

Dr. Croce explains that miRNAs are thought to play important roles in regulating gene expression during development and cell differentiation. MiRNAs inhibit the function of their targets, typically messenger RNA, which is involved in gene expression. They either degrade the messenger RNA or block its translation. Cells in organisms from yeast to mammals make interfering RNA to shut off gene expression in development.

Dr. Croce and his colleagues had previously shown that deletions in miRNA genes were involved in B-cell chronic lymphocytic leukemia (CLL), the most common adult leukemia in the Western world. They also had reported that human miRNA genes are frequently located in "fragile" areas of the genome that are vulnerable to mutation. "We think the miRNA genes are in fact involved in many human cancers," he says.

"As a result, we have a number of markers that allow us to characterize spe
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
22-Jun-2004


Page: 1 2

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
4. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
5. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
6. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
7. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
8. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
9. Jefferson scientists use gene repair technique to change albino mice hairs to black
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/27/2019)... ... ... Shoreline Biome , a microbiome research company that develops tools for ... CEO and Karen Woodward as its VP of Business Development. , These two ... and expand the company’s sales worldwide. , Prior to joining Shoreline Biome, Bill McKenzie ...
(Date:8/27/2019)... ... August 27, 2019 , ... Advancements with ... This episode is scheduled to broadcast 4Q/2019. Check local listings for more information. ... investment and manufacturing company. The show will highlight how Debiopharm is working to ...
(Date:8/23/2019)... ... August 22, 2019 , ... R121 ... their acquisition in June of 2018. Along with the name change, this rebranding ... “Our goal was to create a cohesive brand that blended our core foundation ...
Breaking Biology News(10 mins):
(Date:9/8/2019)... NEW YORK (PRWEB) , ... September 04, 2019 ... ... New York Academy of Sciences announced today the three Winners and ... Supporting outstanding postdoctoral scientists from academic research institutions across New York, New Jersey, ...
(Date:9/4/2019)... ... September 03, 2019 , ... ... advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, ... & Technology will present at the upcoming Nordic Life Science Days (NLS ...
(Date:8/29/2019)... ... August 29, 2019 , ... Scientists have mapped ... they hope will ultimately help protect the multibillion-dollar grape industry that produces juice, ... Technology faculty and alumni sequenced the microbiome found within tumors of grapevines afflicted ...
(Date:8/29/2019)... ... August 29, 2019 , ... Prof. Stephen ... Sustainable Medicines in Africa program, which includes a master’s degree in biotechnology innovation ... September 2nd through 13th, 2019. Topics to be addressed include Manufacturing, Quality, ...
Breaking Biology Technology:
Cached News: