HOME >> BIOLOGY >> NEWS
Jefferson researchers uncover biochemical clues to how cells migrate in embryos

Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer Center are gaining a better understanding of the cues that help guide cells to the right places in developing embryos.

Steven Farber, Ph.D., assistant professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his co-workers have found that statins, the group of anti-cholesterol drugs that includes the popular Lipitor, interfere with a biochemical pathway vital to the migration of germ cells in embryonic zebrafish. In all organisms, including humans, germ cells are stem cells that are destined to become either sperm or egg cells, and they must migrate from one place in the developing embryo to another before development can occur.

A better understanding of germ cell migration, Dr. Farber says, and cell migration in general, might lead to insights into disease processes, including cancer. Cancer turns deadly when it spreads to other areas in the body.

Dr. Farber and his co-workers report their findings in the February 2004 issue of the journal Developmental Cell.

"We have identified an enzyme in zebrafish and there is a companion paper in the journal identifying the same pathway in fruit flies showing that if you interfere with this enzyme, germ cells don't migrate correctly," he says. "It's likely a general feature of all vertebrates, and not simply a fish-specific observation."

In earlier work, Dr. Farber had studied the effects of statins on lipid metabolism in zebrafish embryos. Dr. Farber knew that researchers at New York University School of Medicine had found that a mutation in a gene for an enzyme, HMG-CoAReductase, disrupted germ cell migration in fruit flies. In both the fruit fly and all vertebrate embryos, germ cells need to migrate through the developing embryo to their final destination, where they develop into sperm or egg cells. HMG-CoAReductase also plays a central role in chole
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
16-Feb-2004


Page: 1 2 3

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
6. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
7. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
8. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
9. Jefferson scientists use gene repair technique to change albino mice hairs to black
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
(Date:4/21/2015)... , April 21, 2015 ... government policies are boosting access control systems market in ... According to a recently published report by TechSci Research ... ", the access control systems market in ... billion by 2020.The access control systems market in the ...
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
(Date:5/21/2015)... 2015 /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: ... company focused on the development of autologous cell ... the International Society for Cellular Therapy (ISCT) on ... currently in a Phase 1/2 clinical trial.  The ... from 5:30 PM to 7:00 PM local time, ...
(Date:5/20/2015)... Calif. , May 20, 2015 ... today presented preliminary data demonstrating the ability of ... pulmonary fibrosis (IPF) from other interstitial lung diseases ... suggest the classifier,s potential to help thousands of ... resolve ambiguity in IPF diagnosis – a frequent ...
(Date:5/20/2015)... , May 19, 2015 Research and Markets ... of the "Global Cell Therapy Market Outlook 2020 ... of cell therapy in tissue and regenerative medicine is ... no other options which could help in the growth ... this segment but they are unable to form new ...
(Date:5/20/2015)... 20, 2015  Health eCareers, the healthcare industry,s ... with job seekers looking for the flexibility of ... mobile and online tool dedicated exclusively to temporary ... SHIFT enables employers to quickly find and ... per diem and other temporary positions, eliminating the ...
Breaking Biology Technology:RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3
Cached News: