HOME >> BIOLOGY >> NEWS
Jefferson researchers uncover biochemical clues to how cells migrate in embryos

Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer Center are gaining a better understanding of the cues that help guide cells to the right places in developing embryos.

Steven Farber, Ph.D., assistant professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his co-workers have found that statins, the group of anti-cholesterol drugs that includes the popular Lipitor, interfere with a biochemical pathway vital to the migration of germ cells in embryonic zebrafish. In all organisms, including humans, germ cells are stem cells that are destined to become either sperm or egg cells, and they must migrate from one place in the developing embryo to another before development can occur.

A better understanding of germ cell migration, Dr. Farber says, and cell migration in general, might lead to insights into disease processes, including cancer. Cancer turns deadly when it spreads to other areas in the body.

Dr. Farber and his co-workers report their findings in the February 2004 issue of the journal Developmental Cell.

"We have identified an enzyme in zebrafish and there is a companion paper in the journal identifying the same pathway in fruit flies showing that if you interfere with this enzyme, germ cells don't migrate correctly," he says. "It's likely a general feature of all vertebrates, and not simply a fish-specific observation."

In earlier work, Dr. Farber had studied the effects of statins on lipid metabolism in zebrafish embryos. Dr. Farber knew that researchers at New York University School of Medicine had found that a mutation in a gene for an enzyme, HMG-CoAReductase, disrupted germ cell migration in fruit flies. In both the fruit fly and all vertebrate embryos, germ cells need to migrate through the developing embryo to their final destination, where they develop into sperm or egg cells. HMG-CoAReductase also plays a central role in chole
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
16-Feb-2004


Page: 1 2 3

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
6. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
7. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
8. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
9. Jefferson scientists use gene repair technique to change albino mice hairs to black
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
(Date:7/24/2014)... is available in German . ... 300 million asthma sufferers worldwide, a further 600 million ... of the global population contending with allergic rhinitis (allergic ... also affect other organs and parts of the body ... intestine (in the form of inflammatory bowel diseases such ...
(Date:7/24/2014)... is available in German . ... recognize and respond to threats to health, and to ... understanding of the mechanism underlying immunologic memory, however, has ... converged to support the hypothesis that the persistence of ... with stem-cell-like potential. Until now, there was no conclusive ...
(Date:7/23/2014)... of identical twins has found that early reading skill ... the journal Child Development , was conducted by ... London. , "Since reading is an ability that can ... according to Stuart J. Ritchie, research fellow in psychology ... "Early remediation of reading problems might aid not only ...
Breaking Biology News(10 mins):New drugs to combat asthma and the like 2New drugs to combat asthma and the like 3Experiments prove 'stemness' of individual immune memory cells 2Experiments prove 'stemness' of individual immune memory cells 3Stronger early reading skills predict higher intelligence later 2
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Genomics and Proteomics Analytical Instruments Market 2014-2018" report ... Genomics is the study of the ... of the structure and functions of proteomes or sets ... and technology. Genomics involves the mapping of genes and ...
(Date:7/24/2014)... 24, 2014  CorMedix Inc. (NYSE MKT: CRMD), ... therapeutic products for the prevention and treatment of ... notice on July 18, 2014 from the NYSE ... the CorMedix plan to regain compliance with continued ... the NYSE-MKT is continuing the Company,s listing and ...
(Date:7/24/2014)... 24, 2014  Neogen Corporation (Nasdaq: NEOG ... its potential revenue from new rodenticide research are premature. ... analysts on July 22, 2014, Neogen,s CEO commented about ... research. "It was my intent Tuesday at ... of a new type of rodenticide, but certainly not ...
(Date:7/24/2014)... Toronto, Canada (PRWEB) July 24, 2014 ... for Optimizing Dose Escalation in First in Human Studies” ... to make better go/no-go decisions. , With increasing R&D ... market, pharmaceutical companies need to maximize the knowledge collected ... go/no-go decisions and improve success in late stage development. ...
Breaking Biology Technology:Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3Neogen comments on SenesTech 2Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2
Cached News: