HOME >> BIOLOGY >> NEWS
Jefferson researchers uncover biochemical clues to how cells migrate in embryos

Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer Center are gaining a better understanding of the cues that help guide cells to the right places in developing embryos.

Steven Farber, Ph.D., assistant professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his co-workers have found that statins, the group of anti-cholesterol drugs that includes the popular Lipitor, interfere with a biochemical pathway vital to the migration of germ cells in embryonic zebrafish. In all organisms, including humans, germ cells are stem cells that are destined to become either sperm or egg cells, and they must migrate from one place in the developing embryo to another before development can occur.

A better understanding of germ cell migration, Dr. Farber says, and cell migration in general, might lead to insights into disease processes, including cancer. Cancer turns deadly when it spreads to other areas in the body.

Dr. Farber and his co-workers report their findings in the February 2004 issue of the journal Developmental Cell.

"We have identified an enzyme in zebrafish and there is a companion paper in the journal identifying the same pathway in fruit flies showing that if you interfere with this enzyme, germ cells don't migrate correctly," he says. "It's likely a general feature of all vertebrates, and not simply a fish-specific observation."

In earlier work, Dr. Farber had studied the effects of statins on lipid metabolism in zebrafish embryos. Dr. Farber knew that researchers at New York University School of Medicine had found that a mutation in a gene for an enzyme, HMG-CoAReductase, disrupted germ cell migration in fruit flies. In both the fruit fly and all vertebrate embryos, germ cells need to migrate through the developing embryo to their final destination, where they develop into sperm or egg cells. HMG-CoAReductase also plays a central role in chole
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
16-Feb-2004


Page: 1 2 3

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
6. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
7. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
8. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
9. Jefferson scientists use gene repair technique to change albino mice hairs to black
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring, and the ... five (5) year funding commitment by Securus to ... rehabilitation and reentry support to more inmates and ... 2004, the Prison Entrepreneurship Program (PEP) is an ...
(Date:12/2/2016)... , December 1, 2016 ... (Fingerprint, Voice), Future Technology (Iris Recognition System), Vehicle ... - Global Forecast to 2021", published by MarketsandMarkets, ... Million in 2016, and is projected to grow ... CAGR of 14.06%.      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/30/2016)... WARSAW, Poland , Nov. 30, 2016 Not many of us realize ... crucial aspects of recovery so we need to do it well. Inadequate sleep levels ... problems, high blood pressure, stroke, diabetes, and even cancer. Maybe now is ... Christmas present that could help them to manage their sleep quality? ... ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... report "Acrylic Processing Aid Market by Polymer Type (PVC), Fabrication Process (Extrusion, Injection Molding), End-Use ... published by MarketsandMarkets, the global market size was USD 645.4 Million in 2016, ... CAGR of 6.2% between 2016 and 2026. Continue ... ... , , ...
(Date:12/7/2016)... 2016  Genprex, Inc. a biopharmaceutical company focused ... today announced that it has retained ICR Healthcare, ... communications and advisory firm, to develop and implement ... combine investor relations, public relations and digital communications ... of Genprex and its lead candidate Oncoprex, which ...
(Date:12/7/2016)... and ANN ARBOR, Mich. , ... biopharmaceutical company developing breakthrough immune modulatory medicines, announced today ... the Company,s lead therapeutic candidate, LYC-30937- E nteric ... a debilitating skin disease that is estimated to affect ... United States , with approximately 1.5 - 3 ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... ... wastewater treatment and resource recovery solutions for industrial facilities, today announced that one ... be the first to use Cambrian’s novel water-energy purchase agreement (WEPA). Under the ...
Breaking Biology Technology:
Cached News: