HOME >> BIOLOGY >> NEWS
Jefferson scientists find gene expression pattern may predict behavior of leukemia

The expression pattern of certain genes may someday help doctors to diagnose and predict whether or not an individual has an aggressive form of B-cell chronic lymphocytic leukemia (CLL), Jefferson cancer researchers have found.

Scientists, led by Carlo Croce, M.D., director of Jefferson's Kimmel Cancer Center and professor and chair of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, looked at the expression of genes that encoded microRNAs (miRNAs), tiny pieces of genetic material that are thought to be important in the regulation of gene expression and in the development of cancer. MiRNAs can serve as stop signs for gene expression and protein synthesis, and are thought to play important roles in regulating gene expression in development.

Reporting in both the online and the August 10 print version of the Proceedings of the National Academy of Sciences, the researchers taking advantage of a microarray chip Dr. Croce and his colleagues designed that carries all the known human miRNA genes compared the expression of miRNA genes in human CLL samples with that of normal white blood cells, or lymphocytes, called CD5+ B cells. CLL, the most common adult leukemia in the Western world, is characterized by an abnormal increase in the number of B cells.

"We found two specific genetic signatures," Dr. Croce says. One expression pattern of miRNA genes in CLL correlated with a deletion of a chromosomal region called 13q14. This region contained two small miRNA genes that are turned off in about 60 percent of CLL cases. The deletions at 13q14 represent an indicator of a good prognosis for the disease, he notes.

The other miRNA signature was associated with mutations in the Ig or immunoglobulin gene, which also indicates a good prognosis, says Dr. Croce. The researchers also found that the expression of one of the miRNA genes, miR-16, was reduced in both signatures.

"This suggests that CLL
'"/>


10-Aug-2004


Page: 1 2

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
3. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
4. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
5. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
6. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
7. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
8. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
9. Jefferson scientists use gene repair technique to change albino mice hairs to black
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... & Trends - Industry Forecast to 2025" report to their ... The ... CAGR of around 8.8% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
(Date:3/20/2017)... 20, 2017 PMD Healthcare announces the release ... Wellness Management System (WMS), a remote, real-time lung health ... PMD Healthcare is a Medical Device, Digital Health, and ... to creating innovative solutions that empower people to improve ... focus, PMD developed the first ever personal spirometer, Spiro ...
(Date:3/7/2017)... 2017 Brandwatch , the leading social intelligence company, ... Trust to uncover insights to support its reporting, help direct ... The UK,s leading youth charity will be using Brandwatch Analytics social ... a better understanding of the topics and issues that are a ... ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... ... March 29, 2017 , ... ... dedicated to finding cures for inflammatory bowel diseases (IBD), and ReachMD , ... deliver exclusive content to ReachMD learners. , The partnership, which launched in ...
(Date:3/29/2017)... March 29, 2017  Vermillion, Inc. (NASDAQ: VRML), ... reported on its results for the fourth quarter ... "2016 marked a pivotal year for us ... inclusion, international distribution agreements, major reimbursement progress with ... payer agreements. In addition we cleared our 2 ...
(Date:3/29/2017)... March 29, 2017 "Surging application of gesture ... the government are expected to drive the growth of ... gesture recognition market is expected to be worth USD ... 29.63% between 2017 and 2022. The touchless sensing market ... 2022, growing at a CAGR of 17.44% between 2017 ...
(Date:3/29/2017)... SHANGHAI , March 29, 2017 ... technology platform company dedicated to biologics and a ... received the 2017 Asia-Pacific Best Bioprocessing Excellence Award ... Asia-Pacific Bioprocessing Excellence Awards aims to recognize outstanding ... of tomorrow. Featuring top bioprocessing and biomanufacturing experts ...
Breaking Biology Technology:
Cached News: