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Jefferson scientists find gene expression pattern may predict behavior of leukemia

involves changes in miRNA, and that you can predict the behavior of CLL depending on the miRNA genetic signature," says Dr. Croce. "We think we might be able to predict CLL behavior based on the miR-16 signature because that is the only common denominator between the two signatures with good prognosis." But before using miRNA expression as any kind of clinical biomarker, says Dr. Croce, the results need to be verified in a clinical trial screening thousands of patients.

Dr. Croce and his colleagues had previously shown that deletions in miRNA genes were involved in B-cell CLL. They also had reported that human miRNA genes are frequently located at sites of the genome that are altered in human cancers.

The work might enable scientists to gain a better understanding of the roles of miRNAs in cancer and provide targets for future drug development.


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10-Aug-2004


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