HOME >> BIOLOGY >> NEWS
Jefferson scientists use gene repair technique to change albino mice hairs to black

Editor's Note: This information is embargoed for release on Dec. 28, 1999, at 3 p.m. EST

The technique may someday be used in treating inherited disease.

Researchers at Jefferson Medical College have used an innovative "gene repair" technique to genetically change white albino mice hairs to black. The technique has not only turned hairs black, but has showed that such changes are stable and long lasting in skin cells.

The work holds promise as a potential treatment for some hereditary diseases by correcting the genetic mutation from which they arise.

Kyonggeun Yoon, Ph.D., associate professor of dermatology and cutaneous biology and biochemistry and molecular pharmacology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and postdoctoral fellow Vitali Alexeev, Ph.D., in collaboration with a team of scientists at the University of Pennsylvania, corrected a single alteration in the gene that controls skin color in albino mice cells.

The scientists, in what they dub "localized gene therapy," delivered a small oligonucleotide - DNA interspersed with small amounts of RNA - to the melanocytes, or skin color-producing cells. The "oligo" triggers the actual gene repair process. They both injected the oligonucleotide and applied it topically.

The researchers' work appears in the January issue of the journal Nature Biotechnology.

"We showed that it's possible to change the hair color in a live animal, and not just in the color-producing cells cultured in a test tube," says Dr. Alexeev, noting that only a few tiny hairs were blackened and were not visible without a microscope. Last year, Dr. Yoon and Dr. Alexeev reported that, using this gene repair technique, they could change mouse melanocytes from white to black in the test tube.

The scientists would like to continue to refine their technique. "We have a lot to improve on, such as oligonucleotide delivery to the melanocyt
'"/>

Contact: Steven Benowitz
steven.benowitz@mail.tju.edu
215-955-5291
Thomas Jefferson University
27-Dec-1999


Page: 1 2

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2020)... ... 13, 2020 , ... Acumed LLC today announced that it ... of the Louisville-based company’s orthobiologics portfolio. Under the terms of the agreement, Acumed ... phosphate-based bone allograft (Trabexus) and calcium phosphate-based biocement (Fortera). Vivorte will continue to ...
(Date:3/11/2020)... ... 11, 2020 , ... Polysense Technologies Inc., (Polysense) an innovation ... infrared touch-free monitoring product family, a standalone thermal meter WxS x800-IRTMS, and an ... for cloud connectivity such as NB-IoT, Wi-Fi, LoRaWAN, and 4G LTE, , “Temperature ...
(Date:3/9/2020)... ... March 09, 2020 , ... ... a steep growth rate of 64% last year, as enterprises sought to ... from Everest Group. Unfortunately, only 13% of all transformation efforts delivered the ...
Breaking Biology News(10 mins):
(Date:3/19/2020)... ... March 17, 2020 , ... ... and manufacturing collaboration agreement with pioneering gene circuit company Senti Biosciences, Inc. ... ovarian cancer and other solid tumor indications. The collaboration will leverage RoosterBio’s ...
(Date:3/13/2020)... ... 2020 , ... Today, DuPont Nutrition & Biosciences (DuPont) announced ... pioneer in the field of microbiome science, which focuses on microbes that live ... based at University College Cork and Teagasc Moorepark. , Representatives from both organizations ...
(Date:3/10/2020)... (PRWEB) , ... March 10, 2020 , ... Ortho Clinical ... through innovative laboratory solutions, announced its ORTHOTM Sera, ID-MTS, a suite of extended antigen ... transfusion, is cleared to run on ORTHO VISION® and ORTHO VISION® Max in the ...
(Date:3/10/2020)... (PRWEB) , ... March 10, 2020 , ... Lifecycle ... on 13 acres in Cleburne, Texas to be used as a biopharmaceutical and biotechnology ... global headquarters and sales offices as well as its production and development hub. The ...
Breaking Biology Technology:
Cached News: