HOME >> BIOLOGY >> NEWS
Jefferson scientists use gene repair technique to change albino mice hairs to black

Editor's Note: This information is embargoed for release on Dec. 28, 1999, at 3 p.m. EST

The technique may someday be used in treating inherited disease.

Researchers at Jefferson Medical College have used an innovative "gene repair" technique to genetically change white albino mice hairs to black. The technique has not only turned hairs black, but has showed that such changes are stable and long lasting in skin cells.

The work holds promise as a potential treatment for some hereditary diseases by correcting the genetic mutation from which they arise.

Kyonggeun Yoon, Ph.D., associate professor of dermatology and cutaneous biology and biochemistry and molecular pharmacology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and postdoctoral fellow Vitali Alexeev, Ph.D., in collaboration with a team of scientists at the University of Pennsylvania, corrected a single alteration in the gene that controls skin color in albino mice cells.

The scientists, in what they dub "localized gene therapy," delivered a small oligonucleotide - DNA interspersed with small amounts of RNA - to the melanocytes, or skin color-producing cells. The "oligo" triggers the actual gene repair process. They both injected the oligonucleotide and applied it topically.

The researchers' work appears in the January issue of the journal Nature Biotechnology.

"We showed that it's possible to change the hair color in a live animal, and not just in the color-producing cells cultured in a test tube," says Dr. Alexeev, noting that only a few tiny hairs were blackened and were not visible without a microscope. Last year, Dr. Yoon and Dr. Alexeev reported that, using this gene repair technique, they could change mouse melanocytes from white to black in the test tube.

The scientists would like to continue to refine their technique. "We have a lot to improve on, such as oligonucleotide delivery to the melanocyt
'"/>

Contact: Steven Benowitz
steven.benowitz@mail.tju.edu
215-955-5291
Thomas Jefferson University
27-Dec-1999


Page: 1 2

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2017)... LONDON , Feb. 22, 2017 ... by 2021, ABI Research identifies four technologies that ... solutions to secure significant share in the changing ... payments, and passive authentication.   "Companies ... it comes to security," says Dimitrios Pavlakis ...
(Date:2/13/2017)... 2017  RSA Conference -- RSA, a Dell Technologies ... to enhance fraud detection and investigation across digital ... Fraud & Risk Intelligence Suite. The new platform ... insights from internal and external sources as well ... customers from targeted cybercrime attacks. "Fraudsters ...
(Date:2/8/2017)... (NASDAQ: AWRE ), a leading supplier of biometrics ... and year ended December 31, 2016. Revenue ... to $6.9 million in the same quarter last year. Operating ... compared to $2.6 million in the fourth quarter of 2015. ... million, or $0.02 per diluted share, which compares to $1.8 ...
Breaking Biology News(10 mins):
(Date:3/1/2017)... 2017  Elizabeth Young and Joshua Rosenthal , ... Washington University,s Health Workforce Speaker series. http://bit.ly/2lA6C8B ... will be speaking on March 9, 2017 at the ... Washington, DC at 12:00pm. The ... renowned speakers to examine new workforce configurations, their outcomes ...
(Date:2/28/2017)... ... February 28, 2017 , ... ... Inc. (Newark, DE) have formed a strategic partnership to develop and market ... renewable energy laboratories. These automated testing solutions will save analysis time and ...
(Date:2/28/2017)... and REYKJAVIK, Iceland , Feb. ... AppTec group company and the contract genomics organization enabling ... officer Hannes Smarason has been appointed as the company,s chief ... Long and Alex Fowkes have been named ... "WuXi NextCODE is executing on its vision to enable ...
(Date:2/28/2017)... (PRWEB) , ... February 28, 2017 , ... ... to their function as well as to their processing and transport properties. With ... on a wide variety of samples. The Litesizerâ„¢ 100 gives rapid and accurate ...
Breaking Biology Technology:
Cached News: