HOME >> BIOLOGY >> NEWS
Jefferson scientists use gene repair technique to change albino mice hairs to black

Editor's Note: This information is embargoed for release on Dec. 28, 1999, at 3 p.m. EST

The technique may someday be used in treating inherited disease.

Researchers at Jefferson Medical College have used an innovative "gene repair" technique to genetically change white albino mice hairs to black. The technique has not only turned hairs black, but has showed that such changes are stable and long lasting in skin cells.

The work holds promise as a potential treatment for some hereditary diseases by correcting the genetic mutation from which they arise.

Kyonggeun Yoon, Ph.D., associate professor of dermatology and cutaneous biology and biochemistry and molecular pharmacology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and postdoctoral fellow Vitali Alexeev, Ph.D., in collaboration with a team of scientists at the University of Pennsylvania, corrected a single alteration in the gene that controls skin color in albino mice cells.

The scientists, in what they dub "localized gene therapy," delivered a small oligonucleotide - DNA interspersed with small amounts of RNA - to the melanocytes, or skin color-producing cells. The "oligo" triggers the actual gene repair process. They both injected the oligonucleotide and applied it topically.

The researchers' work appears in the January issue of the journal Nature Biotechnology.

"We showed that it's possible to change the hair color in a live animal, and not just in the color-producing cells cultured in a test tube," says Dr. Alexeev, noting that only a few tiny hairs were blackened and were not visible without a microscope. Last year, Dr. Yoon and Dr. Alexeev reported that, using this gene repair technique, they could change mouse melanocytes from white to black in the test tube.

The scientists would like to continue to refine their technique. "We have a lot to improve on, such as oligonucleotide delivery to the melanocyt
'"/>

Contact: Steven Benowitz
steven.benowitz@mail.tju.edu
215-955-5291
Thomas Jefferson University
27-Dec-1999


Page: 1 2

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
(Date:7/28/2014)... of Medicine have pinpointed a mechanism in part of the ... blood, linking it to both type 1 and type 2 ... of Proceedings of the National Academies of Sciences . ... located in a part of the hypothalamus known as the ... that control glucose levels in the blood," said lead author ...
(Date:7/28/2014)... the top 10 U.S. cities that have seen an ... as frequent road closures, overwhelmed storm drains and compromised ... NOAA technical report. , This nuisance flooding, caused by ... coasts, between 300 and 925 percent since the 1960s. ... Frequency Changes around the United States, also finds Annapolis ...
(Date:7/28/2014)... has identified areas of the Earth that are high ... , Europe is particularly vulnerable, as it has the ... cent, of any continent in ,refugia, areas of ... conditions remain relatively constant during times of great environmental ... mostly in Scandinavia and Scotland. , The biggest ...
Breaking Biology News(10 mins):Glucose 'control switch' in the brain key to both types of diabetes 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2
(Date:7/29/2014)... 2014 A new report by ... applications and geography) - Size, Share, Global Trends, Company ... Forecast, 2013 - 2020", suggests that the global surgical ... 2020 registering a CAGR of 11.1% from 2014 to ... the electro surgical devices in operative procedures by providing ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 July ... vaccine pioneer in the biotechnology industry, announced that ... Coast Securities, Inc. to explore financing opportunities that ... technology, a breakthrough vaccine platform with the potential ... The company exclusively licensed the well-established LAMP platform ...
(Date:7/29/2014)... 2014 DisasterTalk is a texting app which ... phone masts or other transmitters are down. The app can ... without the need for any Wi-Fi, and can also use ... new app has launched as a housing report ... high risk of being affected by natural disasters. With the ...
(Date:7/29/2014)... The first product launch from start-up Hurley ... robotics. What sets Droidles completely apart from other stand ... them to communicate, share code with each other and ... “The invention is the system,” said Hurley Research founder ... of their own, both physically and on the internet." ...
Breaking Biology Technology:Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2
Cached News: