HOME >> BIOLOGY >> NEWS
Jefferson scientists use gene repair technique to change albino mice hairs to black

es," says Dr. Yoon, who is also a member of the Jefferson Institute of Molecular Medicine. "We're still trying to find the optimum conditions for delivery of the oligonucleotides into mouse skin. The skin is a good organ to do this. It's accessible and easy to monitor for changes."

The researchers also hope to improve the delivery system because mouse and human skin differ.

In the gene repair technique, the gene alteration, known as a "point mutation," was in the gene for a key enzyme, tyrosinase, which is involved in making melanin and in pigmentation. By correcting the alteration, tyrosinase activity was restored and melanin was again produced.

Dr. Yoon used the technique on melanin-producing cells as a model system to test a hypothesis. "We wanted to see what we could visualize and follow using this system," she says.

Dr. Yoon and former Jefferson researcher Eric Kmiec, Ph.D., developed the gene-fixing technique several years ago. Scientists can synthesize a small oligonucleotide that has the capability to find and attach itself to a certain part of a gene. The small genetic vehicle is designed to trigger the cell's normal DNA repair system into action as well. The repair mechanism scans the DNA looking for any mismatches or two strands of DNA that don't seem in sync. When it finds a mismatch, it replaces one of the chemical bases with one that fits better. The scientists, then, can use this natural repair system to correct a bad mutation.

The gene-repair technique is far from perfected, Dr. Yoon says. "Much more research is needed to improve the design and make this technology generally applicable."


'"/>

Contact: Steven Benowitz
steven.benowitz@mail.tju.edu
215-955-5291
Thomas Jefferson University
27-Dec-1999


Page: 1 2

Related biology news :

1. Jefferson Lab detector technology aids development of cystic fibrosis therapy
2. Jefferson scientists find gene expression pattern may predict behavior of leukemia
3. Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
4. Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
5. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
6. Jefferson and Brigham and Womens researchers find blue light important for setting biological clock
7. Jefferson Lab experiment generates THz radiation 20,000 times brighter than anyone else
8. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory
9. Jefferson scientists show how collagen gene mutation leads to osteoarthritis
10. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
11. Jefferson scientists propose mechanism to control the bodys red blood cell and platelet production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... Md. (PRWEB) , ... July 30, 2020 , ... ... Innovation Research (SBIR) Phase II contract awarded by the Joint Science & Technology ... of this project is to develop, optimize, and scale-up a highly efficient mammalian ...
(Date:7/22/2020)... SANTA BARBARA, Calif. (PRWEB) , ... July 21, ... ... consulting firm driving digital transformation and innovation in technology and compliance, announces a ... and medical device companies must ensure every layer of their technology stack complies ...
(Date:7/18/2020)... ... ... Commercial launch readiness is a critical stage in a product life cycle. While the ... economic downturn will only increase price pressures overall for the industry. The era of ... every product launch is critical. However, history shows that only a third of product ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... Mich. (PRWEB) , ... August 12, 2020 , ... ... Group, Inc. (EMMA International), a global leader in FDA compliance consulting has ... the nation’s fastest-growing private companies. The list represents a unique look at the ...
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, the global ... has been named one of the 100 most inspiring individuals in the life-sciences ... are selected based on how they have inspired their colleagues and affected positive ...
(Date:7/31/2020)... ... ... R3 Stem Cell International is now offering patients the opportunity to receive four ... may choose which extremities they would like treated. , Several studies have shown just ... R3 International, umbilical cord tissue is obtained from a lab with a long history ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified ... systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... one or two switches in a push-pull configuration; yielding fast fall time for ...
Breaking Biology Technology:
Cached News: