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"A person cannot survive more than a few hours having cerebral malaria," Posner said.

The next step will be to determine whether it is safe when administered in large doses. Preliminary safety results are encouraging, Posner said.

Malaria is a menace in regions stretching from Africa to the Caribbean islands, and from Central America to Asia and India. The disease is spread by a genus of mosquitos called Anopheles, which pick up the parasite when they bite an infected person. The insects then transmit infected blood to other people. Anopheles mosquitos are found in portions of the United States, where reports of malaria have historically been rare since the 1930s but where public health officials are increasingly concerned.

The research is being funded by the National Institutes of Health and the Burroughs Wellcome Fund.

(The scientific paper is available on-line at the following Web address: http://pubs.acs.org/hotartcl/jmcmar/jmcmar.html).

Another paper about the synthesis of similar antimalarial compounds will be published in March 1998 in Tetrahedron Letters, an international science journal published in the United Kingdom.

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Contact: Emil Venere
emil@jhu.edu
410-516-7160
Johns Hopkins University
12-Feb-1998