HOME >> BIOLOGY >> NEWS
Johns Hopkins scientists create forgetful mouse

Studying mice, scientists from Johns Hopkins have successfully prevented a molecular event in brain cells that they've found is required for storing spatial memories. Unlike regular mice, the engineered rodents quickly forgot where to find a resting place in a pool of water, the researchers report in the March 7 issue of the journal Cell.

The experiments are believed to be the first to prove that subtly altering the chemistry of a certain protein can profoundly affect a brain cell's ability to respond to external stimulation, a process called neuronal plasticity, long thought to underlie learning and memory.

By genetically altering part of a receptor that binds glutamate -- the most important excitatory chemical in the brain -- the scientists created a version of the protein that could not be modified by adding phosphate groups. In their experiments, preventing phosphorylation of the receptor kept it from responding normally to external stimulation in the lab and limited how long animals could store new memories.

"Since 1986, phosphorylation has been recognized as a key to modulating receptor responses to neurotransmitters like glutamate, but this is the first demonstration that phosphorylation of a particular target protein mediates the processes we believe are behind learning and memory," says Richard Huganir, Ph.D., professor of neuroscience in the Johns Hopkins School of Medicine's Institute for Basic Biomedical Sciences. "This new work shows that phosphorylation of this target protein does indeed affect an animal's ability to remember."

Mice with the "phosphate-free" version of the protein, known as GluR1, learned to find a hidden platform in a pool of water as well as normal mice, but couldn't remember its position eight hours later, the researchers report. In contrast, normal mice remembered what they'd learned even after 24 hours.

"Rodents' spatial learning and memory is highly developed because they must navigat
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
7-Mar-2003


Page: 1 2 3

Related biology news :

1. Yale professor receives Johnson & Johnson Focused Giving award
2. Marian Johnson-Thompson wins 2004 Alice C. Evans Award
3. Conservation International & SC Johnson invest in Ecuadors rainforest to offset climate impacts
4. Johns Hopkins gene hunters pinpoint new cancer gene target
5. OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine
6. Johns Hopkins receives $24 million from Donald W. Reynolds Foundation to study sudden cardiac death
7. Johns Hopkins researchers devise methods to evaluate disaster drills
8. A bed of microneedles: Johns Hopkins scientists gadget measures muscle cell force
9. Wake Forest-Johns Hopkins team discovers prostate cancer gene
10. The next generation of scientists recognized at Johns Hopkins
11. Johns Hopkins scientists find brains nose plug

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Johns Hopkins scientists create forgetful mouse

(Date:8/25/2014)... and Emergency Services of Western Australia, a bushfire ADVICE remains ... east of Broome, and Cape Leveque Road approximately 40 kilometres ... is no threat to lives or homes but there is ... a complex of fires burning in the area on both ... The fires are also burning on the eastern side of ...
(Date:8/25/2014)... PHOENIX, Ariz. and ROSEMONT, Ill. Aug. 25, ... technology and innovation, and the Translational Genomics Research ... today announced that the Pac-12,s Arizona State University ... participate in a genetic research study designed to ... in its second year, the joint research project ...
(Date:8/25/2014)... 25, 2014  Scribe Labs unveiled its first ... and saw its campaign surpass the $50,000 funding ... kinematic metrics that help an athlete understand how ... their running mechanics. Built with an advanced 9-axis ... most advanced set of running metrics available outside ...
Breaking Biology News(10 mins):Riddell, TGen team with ASU football to further genetic research into concussion detection 2Riddell, TGen team with ASU football to further genetic research into concussion detection 3runScribe Fitness Wearable Exceeds 200% of Kickstarter Goal in First Week 2
(Date:8/26/2014)... , Aug. 26, 2014 Trovagene, ... Next Generation Dx Summit; Moving Assays to the ... Detection and Monitoring of Cell Free Tumor DNA ... analytical component of its Precision Cancer Monitoring (PCM) ... clinical sensitivity for the detection of tumor DNA ...
(Date:8/26/2014)... YORK , Aug. 26, 2014  That,s Nice ... science markets, today announced the formation of a new ... content development. The expanded team will combine current and ... areas at That,s Nice. Guy ... Content to lead the team. Tiene was previously Director ...
(Date:8/26/2014)... After searching for a more ... , the University of Kansas Medical Center and ... iLab Solutions' web-based core facility management system to ... "We are very pleased that the University of ... on with us,” stated Heather Lorenz, iLab’s VP, ...
(Date:8/26/2014)... NEW YORK , Aug. 26, 2014 /PRNewswire-iReach/ -- ... posture-improving belt, is in full effect on the popular ... to show their support for the biofeedback belt. The ... order to mass-produce and distribute the product. ... is a small device worn on the lower back ...
Breaking Biology Technology:Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 2Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 4That's Nice Announces Expanded Offering For Strategic Content And Public Relations 2That's Nice Announces Expanded Offering For Strategic Content And Public Relations 3The University of Kansas Medical Center and The University of Kansas Cancer Center Select iLab Solutions Web-based Software to Streamline Operations 2The University of Kansas Medical Center and The University of Kansas Cancer Center Select iLab Solutions Web-based Software to Streamline Operations 3PosturePulse, A Biofeedback Posture-Improving Belt, Improves Posture While Sitting or Standing 2
Cached News: