HOME >> BIOLOGY >> NEWS
Johns Hopkins scientists create forgetful mouse

Studying mice, scientists from Johns Hopkins have successfully prevented a molecular event in brain cells that they've found is required for storing spatial memories. Unlike regular mice, the engineered rodents quickly forgot where to find a resting place in a pool of water, the researchers report in the March 7 issue of the journal Cell.

The experiments are believed to be the first to prove that subtly altering the chemistry of a certain protein can profoundly affect a brain cell's ability to respond to external stimulation, a process called neuronal plasticity, long thought to underlie learning and memory.

By genetically altering part of a receptor that binds glutamate -- the most important excitatory chemical in the brain -- the scientists created a version of the protein that could not be modified by adding phosphate groups. In their experiments, preventing phosphorylation of the receptor kept it from responding normally to external stimulation in the lab and limited how long animals could store new memories.

"Since 1986, phosphorylation has been recognized as a key to modulating receptor responses to neurotransmitters like glutamate, but this is the first demonstration that phosphorylation of a particular target protein mediates the processes we believe are behind learning and memory," says Richard Huganir, Ph.D., professor of neuroscience in the Johns Hopkins School of Medicine's Institute for Basic Biomedical Sciences. "This new work shows that phosphorylation of this target protein does indeed affect an animal's ability to remember."

Mice with the "phosphate-free" version of the protein, known as GluR1, learned to find a hidden platform in a pool of water as well as normal mice, but couldn't remember its position eight hours later, the researchers report. In contrast, normal mice remembered what they'd learned even after 24 hours.

"Rodents' spatial learning and memory is highly developed because they must navigat
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
7-Mar-2003


Page: 1 2 3

Related biology news :

1. Yale professor receives Johnson & Johnson Focused Giving award
2. Marian Johnson-Thompson wins 2004 Alice C. Evans Award
3. Conservation International & SC Johnson invest in Ecuadors rainforest to offset climate impacts
4. Johns Hopkins gene hunters pinpoint new cancer gene target
5. OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine
6. Johns Hopkins receives $24 million from Donald W. Reynolds Foundation to study sudden cardiac death
7. Johns Hopkins researchers devise methods to evaluate disaster drills
8. A bed of microneedles: Johns Hopkins scientists gadget measures muscle cell force
9. Wake Forest-Johns Hopkins team discovers prostate cancer gene
10. The next generation of scientists recognized at Johns Hopkins
11. Johns Hopkins scientists find brains nose plug

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Johns Hopkins scientists create forgetful mouse

(Date:10/16/2014)... human body. Battles are won, lost or sometimes ... stalemate—known as tumor dormancy—can last up to 25 ... is poorly understood. , A new computational ... a Professor of Chemistry at Princeton University, may ... the switch to a malignant state. Published today ...
(Date:10/16/2014)... Washington land managers have a new synthesis of recent ... mixed-conifer (MMC) forests in the two states. , ... Eastern Oregon and Washington: A Synthesis of the Relevant ... general technical report published by the U.S. Forest Service,s ... a request from managers for a synthesis of the ...
(Date:10/16/2014)... can be cultivated efficiently, they are anything but ... by monoculture cultivation is becoming increasingly evident. Despite ... form and are regarded as the sole possibility ... quite wrongfully, finds Bernhard Schmid, an ecology professor ... novel form of agriculture and forestry. After all, ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2New report synthesizes best available science on management of moist mixed-conifer forests 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
(Date:10/22/2014)... DUBLIN , Oct. 22, 2014 ... "Organic Electronics Market by Material, by Application, Geography ... report to their offering. Organic electronics, ... a branch of material science which deals with small ... as organic because small molecules and polymers are carbon ...
(Date:10/20/2014)... Oct. 20, 2014 Mapp Biopharmaceutical,s valiant ... antibody therapeutic to fight the Ebola outbreak will ... time-consuming the production of pharmaceuticals can be, according ... said that while some may be taken aback ... those with industry knowledge are well aware of ...
(Date:10/20/2014)... , Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" ... which brings Q3 orders to $5.8 million and provides a good ... in North America and one in the ... bid new projects at record levels," said Peter Bruijns , ... at the end of Q3 than they have been for any ...
(Date:10/20/2014)... , Oct. 20, 2014 PureTech , ... tackling big healthcare problems, announced today the closing ... with participation from Invesco Perpetual, a $120 Billion ... to drive PureTech,s existing pipeline forward and to ... has the scientific creativity to really go for ...
Breaking Biology Technology:Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6
Cached News: