HOME >> BIOLOGY >> NEWS
Joslin researchers clarify mechanisms for beta-cell formation

BOSTON A new study by researchers at Joslin Diabetes Center sheds light on the key mechanisms by which new pancreatic beta cells normally form in response to insulin resistance. These findings may some day help researchers devise ways of staving off full-blown diabetes.

Insulin resistance is a condition in which the body needs increasing amounts of insulin to function properly, including keeping blood glucose levels in the normal range. It is a major contributor to type 2 diabetes, obesity and the metabolic syndrome, which affect nearly one-quarter of the American population.

For years, the body compensates for insulin resistance in order to delay the onset of clinical type 2 diabetes: The pancreas secretes more insulin and, in fact, more insulin-producing beta cells form within the pancreas. This formation of new beta cells is the focus of intensive research: Which cells give rise to these new beta cells and how? (Some researchers, for example, theorize that the new cells are derived from immature ductal cells--the cells that line the ducts of the pancreas.) And what signals this replication of beta cells to occur?

To study these questions, Rohit N. Kulkarni, M.D., Ph.D., Jonathon N. Winnay, and C. Ronald Kahn, M.D., of Joslin Diabetes Center in Boston; Ulupi S. Jhala Ph.D., of The Whittier Institute of the University of California in La Jolla, Calif.; Stan Krajewski Ph.D., at the Burnham Institute in La Jolla; and Marc Montminy M.D., Ph.D., at The Salk Institute for Biological Studies in San Diego, Calif., studied this compensatory growth in two different genetically engineered animal models of insulin resistance called IR/IRS-1 mice and LIRKO mice. Dr. Kahn is the Mary K. Iacocca Professor of Medicine at Harvard Medical School.

The results of immunohistochemical staining suggest that these new beta cells are not derived from duct cells. Rather, the beta-cell growth in insulin-resistant states occurs by "epithelial-to-
'"/>

Contact: Marjorie Dwyer
marjorie.dwyer@joslin.harvard.edu
617-732-2415
Joslin Diabetes Center
16-Sep-2004


Page: 1 2 3

Related biology news :

1. Joslin Diabetes Center honors brothers living 70-plus years with type 1 diabetes
2. Joslin President awarded medal from international diabetes organization
3. Joslin Diabetes Center adds first affiliate in California at Irvine Medical Center
4. New imaging technology at Joslin shown to detect early signs of type 1 diabetes
5. Joslin Diabetes Center launches research section on developmental and stem cell biology
6. Joslin Diabetes Center releases new low impact exercise video
7. Joslin researchers identify key molecule in Type 1 diabetes progression
8. As obesity skyrockets, Joslin Diabetes Center urges action to stem the tide of type 2 diabetes
9. Belgian researchers explore revolutionary approach to angiogenesis
10. Award winning researchers reveal potential new role for Glivec
11. $7.5 Million grant to Yale researchers for role of viruses in cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 04, 2018 , ... ... University of Illinois Extension and Monroe County Economic Development Corporation (EDC), has ... Institute of Food and Agriculture (NIFA) Non-Land Grant College of Agriculture (NLGCA) ...
(Date:10/3/2018)... , ... October 03, 2018 , ... ... York City, announces the appointment of healthcare visionary, Jimmy Lee, as Strategic Advisor ... over 30 years of healthcare industry experience. As a Senior Executive at Anthem, ...
(Date:10/2/2018)... ... October 02, 2018 , ... Through this webinar, sponsored by ... They will also learn the role of calcium kinetics in cardiac safety testing. The ... officer at PPSC Biography; and Tsang Wai Lam, an assay development scientist at PPSC. ...
Breaking Biology News(10 mins):
(Date:9/27/2018)... , ... September 26, 2018 , ... ... are way ahead of their primary care physicians, according to a new Zeldis ... study, patients and doctors were asked about consumer adoption of fitness and health ...
(Date:9/24/2018)... ... September 24, 2018 , ... ReGrow Helmet , ... highest quality and most affordable option for hair regrowth in the comfort of one’s ... on October 2, 2018. , The sophisticated design and advanced technology of the ...
(Date:9/15/2018)... ... 14, 2018 , ... Nationally recognized public accounting and consulting firm Cherry ... of the Firm’s Nashville practice, on her appointment to Launch Tennessee’s Board ... named Managing Partner of the Firm’s Nashville practice in December 2017 . In this ...
(Date:9/12/2018)... ... September 12, 2018 , ... NDA ... professional and former Senior Director of Regulatory Affairs and Quality Systems at WellDoc, ... Director of Regulatory Affairs and Quality Systems at WellDoc, Inc., she conducted quality ...
Breaking Biology Technology:
Cached News: