HOME >> BIOLOGY >> NEWS
Kaposis sarcoma-associated herpesvirus causes no negative health effects in hiv-negative individuals, find University of Pittsburgh researchers

PITTSBURGH, April 9 New research at the University of Pittsburgh shows that a recently discovered herpesvirus, which often leads to Kaposis sarcoma in HIV-positive individuals, has no negative effect on healthy HIV-negative adults. The study is published in the April 15 issue of Blood, a journal of the American Society of Hematology.

Researchers at the Graduate School of Public Health found that human herpesvirus 8 (HHV8), often a precursor to the blood vessel cancer Kaposis sarcoma (KS) in HIV-positive adults, causes no symptoms or only a mild flu-like illness in healthy adults without HIV, and has no negative effects on their immune systems.

"This is the first study to unravel the natural history of primary HHV8 infection in the absence of underlying HIV infection or organ transplantation," said lead author Charles Rinaldo, Ph.D., professor of pathology and infectious diseases and microbiology. "Knowing how HIV-negative, otherwise healthy individuals respond to this virus in terms of symptoms and immune responses is important in preventing related diseases."

In a previous study, Dr. Rinaldo showed that people who are infected with HIV have a poor immune response to HHV8, which he says is likely the reason they are at high risk of contracting KS. This type of cancer can be very aggressive in HIV-infected individuals and in organ transplant recipients; a milder, rare form of KS occurs in some older men.

"Our current study shows that healthy adults produce T cells and antibodies that we believe control the first-time HHV8 infection," said Dr. Rinaldo. "The only signs of disease that we see, if any, are transient, flu-like symptoms." Like all herpesviruses, HHV8 remains, but in a latent form, after the initial infection.

In addition, the study demonstrates that HHV8 infection causes no negative changes in a patients immune system, which is not the case with other, similar herpesviruses such as Epstein-Barr vir
'"/>

Contact: Kathryn Duda
dudak@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
9-Apr-2001


Page: 1 2

Related biology news :

1. Immune co-stimulation and the Kaposis virus
2. Treating metastatic disease with a modified herpesvirus
3. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
4. Pollutant causes delayed flowering in plants
5. Disruption of protein-folding causes neurodegeneration, mental retardation
6. Researchers discover why mutant gene causes colon cancer
7. Analysis fingers causes of desertification
8. Vioxx in high doses causes hypertension
9. Gene mutation causes progressive changes to cell structure in children with Progeria
10. Late invasion of infected cells into the brain causes HIV dementia say Temple researchers
11. Fat cell hormone causes weight loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/9/2019)... ... May 09, 2019 , ... Akadeum Life Sciences today announced ... its microbubble technology. Unlike magnetic-based products, microbubbles use buoyancy to gently separate cells ... who participated in an early access program has been very encouraging and has ...
(Date:5/8/2019)... ... May 08, 2019 , ... ... diameter of 200 microns and a lead-in fiber of 100 microns. With dimensions ... standard and positioning itself as the world leader in the development of fiber ...
(Date:5/2/2019)... (PRWEB) , ... May 01, 2019 , ... ... that give families insight into their future children, announces a new publication titled, ... in the journal of Pregnancy and Child Health. Previous studies had only shown ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... ... April 24, 2019 , ... Inference Solutions ... service organizations, today announced global availability of Inference Studio’s latest version, which makes ... sizes to harness the power of Google’s Contact Center AI (CCAI). ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., ... $2 million bench plant expansion to increase production of methylene malonate monomers and ... and construction of Sirrus’ full-scale production facility, which is scheduled to break ground ...
(Date:4/9/2019)... ... April 09, 2019 , ... USDM ... capacity of life sciences organizations to accelerate innovation and maximize productivity, announces that ... the past 12 months. , USDM’s Cloud Assurance is a managed ...
(Date:4/8/2019)... SAN FRANCISCO (PRWEB) , ... April 08, 2019 , ... ... to accredited investors a $15 million preferred equity investment in the privately held pharmaceutical ... dysfunction. Its leading drug, Lorexys, is targeted at female hypoactive sexual dysfunction disorder and ...
Breaking Biology Technology:
Cached News: