HOME >> BIOLOGY >> NEWS
Kaposis sarcoma-associated herpesvirus causes no negative health effects in hiv-negative individuals, find University of Pittsburgh researchers

PITTSBURGH, April 9 New research at the University of Pittsburgh shows that a recently discovered herpesvirus, which often leads to Kaposis sarcoma in HIV-positive individuals, has no negative effect on healthy HIV-negative adults. The study is published in the April 15 issue of Blood, a journal of the American Society of Hematology.

Researchers at the Graduate School of Public Health found that human herpesvirus 8 (HHV8), often a precursor to the blood vessel cancer Kaposis sarcoma (KS) in HIV-positive adults, causes no symptoms or only a mild flu-like illness in healthy adults without HIV, and has no negative effects on their immune systems.

"This is the first study to unravel the natural history of primary HHV8 infection in the absence of underlying HIV infection or organ transplantation," said lead author Charles Rinaldo, Ph.D., professor of pathology and infectious diseases and microbiology. "Knowing how HIV-negative, otherwise healthy individuals respond to this virus in terms of symptoms and immune responses is important in preventing related diseases."

In a previous study, Dr. Rinaldo showed that people who are infected with HIV have a poor immune response to HHV8, which he says is likely the reason they are at high risk of contracting KS. This type of cancer can be very aggressive in HIV-infected individuals and in organ transplant recipients; a milder, rare form of KS occurs in some older men.

"Our current study shows that healthy adults produce T cells and antibodies that we believe control the first-time HHV8 infection," said Dr. Rinaldo. "The only signs of disease that we see, if any, are transient, flu-like symptoms." Like all herpesviruses, HHV8 remains, but in a latent form, after the initial infection.

In addition, the study demonstrates that HHV8 infection causes no negative changes in a patients immune system, which is not the case with other, similar herpesviruses such as Epstein-Barr vir
'"/>

Contact: Kathryn Duda
dudak@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
9-Apr-2001


Page: 1 2

Related biology news :

1. Immune co-stimulation and the Kaposis virus
2. Treating metastatic disease with a modified herpesvirus
3. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
4. Pollutant causes delayed flowering in plants
5. Disruption of protein-folding causes neurodegeneration, mental retardation
6. Researchers discover why mutant gene causes colon cancer
7. Analysis fingers causes of desertification
8. Vioxx in high doses causes hypertension
9. Gene mutation causes progressive changes to cell structure in children with Progeria
10. Late invasion of infected cells into the brain causes HIV dementia say Temple researchers
11. Fat cell hormone causes weight loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/2/2018)... ... August 02, 2018 , ... RxS LLC (“RxS”), a privately ... announced that Mark Jara, principal of the organization, has been named to PharmaVOICE ... Individuals named to PharmaVOICE 100 are leaders who drive the industry forward and ...
(Date:8/1/2018)... Md. (PRWEB) , ... August 01, 2018 , ... ... software portfolio, announces the release of Limfinity® version 7.1. Limfinity® is the software ... to Limfinity® itself creates new possibilities for both current users and the future ...
(Date:8/1/2018)... JUPITER, Fla. (PRWEB) , ... August 01, 2018 ... ... “YOU” the staff NP, PA’s, RN’s, LPN’s, MA's and Administrative staff. , This ... processing of all the biologics. The course will expose your staff to regenerative ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... ... July 25, 2018 , ... ... managing clinical trial patient and supplies data through its flagship IXRS® 3 ... IRT: Best Practices.” , This podcast features both Almac thought leaders and outside ...
(Date:7/24/2018)... ... July 24, 2018 , ... R3 Stem Cell is ... Vegas. The treatments are offered by Double Board Certified providers, with outcomes significantly improving ... with suppressing symptoms, but have done nothing to help repair and regenerate damaged lung ...
(Date:7/22/2018)... ... July 19, 2018 , ... CallTower ... joined their team. With more than ten years of strategic, result-oriented Channel experience ... expertise as CallTower’s Channel Director for the Southwest and Mountain region. , As ...
(Date:7/22/2018)... ... July 20, 2018 , ... ... automation and IT solutions with 150 employees on both the east and west ... Program. Superior Controls met the high criteria for application expertise, operational excellence ...
Breaking Biology Technology:
Cached News: