HOME >> BIOLOGY >> NEWS
Keeping autoimmunity in check may depend on balance in the immune system

(PHILADELPHIA - April 16, 2002) - Scientists know that the potential to generate dangerous antibodies that attack our own cells and tissues - one of the defining characteristics of autoimmune disorders like lupus - exists in everyone. That potential is unrealized in healthy individuals, but spins out of control in those who develop disease. So, what are the factors that push the potential for producing these antibodies into action and cause autoimmunity in some individuals? A new study from researchers at The Wistar Institute suggests that health depends on maintaining a balance of normal, but countervailing processes in the immune system. New approaches to developing treatments for autoimmunity might focus on influencing this balance.

In lupus and other autoimmune diseases, antibodies against our own cells and tissues are produced by B cells. The body contains billions of B cells that can make antibodies that target infecting viruses and bacteria, but these antibodies can also include ones that can react with "self" - an immunologist's term for our own bodies. One process that normally prevents these B cells from causing harm is that their activity depends on receiving "help" from T helper cells that also become stimulated when an infection occurs. However, another kind of T cell, called a regulatory T cell, may be important in preventing T helper cells from activating B cells with the potential to generate self-reactive antibodies.

Under normal circumstances, according to the Wistar study, a critical balance may exist between T helper cells and regulatory T cells. The researchers saw that providing T helper cells to healthy mice could cause autoreactive B cells to become active, and that removing T helper cells could alleviate disease in lupus-prone mice. They also found that regulatory T cells could stop T helper cells from activating the B cells, suggesting that the presence of self-reactive T helper cells with too few regulatory T cells may be
'"/>

Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
16-Apr-2002


Page: 1 2 3

Related biology news :

1. Keeping your peas and carrots safe to eat
2. Keeping populations of cerulean warbler healthy
3. Keeping a tight rein on cell division
4. Keeping the cold out
5. A pathway to blocking autoimmunity
6. A new hypothesis about autoimmunity. Is it possible to be too clean?
7. Sick Kids researchers pinpoint link between diabetes and nervous system autoimmunity
8. Bacterial proteins cause autoimmunity in the antiphospholipid syndrome
9. Mechanism for generating autoimmunity-suppressing cells identified
10. Atomic structure identified for gene-regulating molecule: Broad implications for cancers, autoimmunity, developmental disorders
11. Infections may trigger autoimmunity via rare, but normal process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... American College of Medical Genetics and Genomics was once again ... of the fastest-growing trade shows during the Fastest 50 Awards ... Las Vegas . Winners are ... of the following categories: net square feet of paid exhibit ... 2015 ACMG Annual Meeting was ranked 23 out of 50 ...
(Date:6/22/2016)... 2016 On Monday, the Department of Homeland ... share solutions for the Biometric Exit Program. The Request ... Protection (CBP), explains that CBP intends to add biometrics ... the United States , in order to deter ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... 7, 2016 /PRNewswire/ - OncoQuest Inc. ("OncoQuest"), a ... of immunotherapeutic products for the treatment of cancer, ... Antibody Manufacturing Development Program with Cytovance Biologics ( ... its oregovomab antibody product. Supported by recent positive ... study in ovarian cancer patients, OncoQuest has engaged ...
(Date:12/7/2016)...  Vyriad Inc. announced today the appointment of ... Directors. "We are delighted to welcome Al ... develop our oncolytic viruses as the next generation of ... , MD, PhD, CEO of Vyriad. "Al and his ... passion for making a difference for cancer patients—their philanthropy ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... treatment and resource recovery solutions for industrial facilities, today announced that one of ... the first to use Cambrian’s novel water-energy purchase agreement (WEPA). Under the WEPA, ...
(Date:12/6/2016)... Dec. 6, 2016 The American Botanical Council ... of arnica ( Arnica montana ) through ABC,s ... HerbMedPro database, a comprehensive, interactive online ... clinical research data on the uses and health ... Naturopathica, a wellness company with healing arts ...
Breaking Biology Technology:
Cached News: