HOME >> BIOLOGY >> NEWS
Keeping autoimmunity in check may depend on balance in the immune system

(PHILADELPHIA - April 16, 2002) - Scientists know that the potential to generate dangerous antibodies that attack our own cells and tissues - one of the defining characteristics of autoimmune disorders like lupus - exists in everyone. That potential is unrealized in healthy individuals, but spins out of control in those who develop disease. So, what are the factors that push the potential for producing these antibodies into action and cause autoimmunity in some individuals? A new study from researchers at The Wistar Institute suggests that health depends on maintaining a balance of normal, but countervailing processes in the immune system. New approaches to developing treatments for autoimmunity might focus on influencing this balance.

In lupus and other autoimmune diseases, antibodies against our own cells and tissues are produced by B cells. The body contains billions of B cells that can make antibodies that target infecting viruses and bacteria, but these antibodies can also include ones that can react with "self" - an immunologist's term for our own bodies. One process that normally prevents these B cells from causing harm is that their activity depends on receiving "help" from T helper cells that also become stimulated when an infection occurs. However, another kind of T cell, called a regulatory T cell, may be important in preventing T helper cells from activating B cells with the potential to generate self-reactive antibodies.

Under normal circumstances, according to the Wistar study, a critical balance may exist between T helper cells and regulatory T cells. The researchers saw that providing T helper cells to healthy mice could cause autoreactive B cells to become active, and that removing T helper cells could alleviate disease in lupus-prone mice. They also found that regulatory T cells could stop T helper cells from activating the B cells, suggesting that the presence of self-reactive T helper cells with too few regulatory T cells may be
'"/>

Contact: Franklin Hoke
hoke@wistar.upenn.edu
215-898-3716
The Wistar Institute
16-Apr-2002


Page: 1 2 3

Related biology news :

1. Keeping your peas and carrots safe to eat
2. Keeping populations of cerulean warbler healthy
3. Keeping a tight rein on cell division
4. Keeping the cold out
5. A pathway to blocking autoimmunity
6. A new hypothesis about autoimmunity. Is it possible to be too clean?
7. Sick Kids researchers pinpoint link between diabetes and nervous system autoimmunity
8. Bacterial proteins cause autoimmunity in the antiphospholipid syndrome
9. Mechanism for generating autoimmunity-suppressing cells identified
10. Atomic structure identified for gene-regulating molecule: Broad implications for cancers, autoimmunity, developmental disorders
11. Infections may trigger autoimmunity via rare, but normal process

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Keeping autoimmunity check may depend balance the immune system

(Date:10/15/2014)... , Oct. 15, 2014 Sandata ... for home and community-based care, today announced it ... implementing Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™) ... is a home health company founded in 1996 ... . The study details ...
(Date:10/15/2014)... Gutenberg University Mainz (JGU) as a full member, ... maintain a significant nationwide standing in the field ... Johannes Gutenberg University Mainz as a full member ... national and international competition for the best minds ... be proud that Mainz University has been recognized ...
(Date:10/15/2014)... 15, 2014 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market releases photos and video of ... on Monday October 13 th . Gino ... and angel investor Mr. Chad A. Verdi rang ... NXT-ID thanked his investors and employees "for their work and dedication ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
(Date:10/20/2014)... Rochelle, Virginia (PRWEB) October 20, 2014 ... of NDA Partners LLC, announced today that Ellen ... and legal support for the pharmaceutical industry, has ... and manager of its legal services practice. ... reports and expert witness and testimony, to top ...
(Date:10/19/2014)... 20, 2014 OCTOBER 20-22, ... (ABIM). ABIM will take place at ... about ABIM 2014 is now available at ... representing companies and organizations from all over ... information on the latest products and developments ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian ... in Asian with analysis and forecast of revenue. The ... grow to around $463.9 million by 2018, at a ... Browse through the TOC of the Asian Automatic patient ... analysis provided. This also provides a glimpse of the ...
(Date:10/19/2014)... The Asian Orthopedic braces and support systems report ... and forecast of revenue. The Orthopedic braces and support systems ... million by 2018, at a developing CAGR of 4.4% from ... Asian Orthopedic braces and support systems market, to get an ... glimpse of the segmentation of orthopedic braces and support systems ...
Breaking Biology Technology:NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
Cached News: