Ketek effective against respiratory tract infections with reduced susceptibility to other antibiotics

A novel investigational antibiotic is effective against respiratory tract infections caused by Streptococcus pneumoniae, including those strains that are resistant to penicillin and/or currently available macrolide antibiotics, according to a study reported today at a major scientific meeting.

The study, presented today at the 11th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Istanbul, Turkey, involved an analysis of data from Phase III studies of Ketek (telithromycin) - the first in a new family of antibiotics called ketolides to be developed for clinical use. The study was designed to evaluate the effectiveness of Ketek in patients with strains of Streptococcus pneumoniae that had reduced susceptibility to penicillin and/or erythromycin. Ketek is currently under review by health authorities in Europe and the U.S. for the treatment of community-acquired pneumonia (CAP), acute bacterial exacerbation of chronic bronchitis (AECB), acute sinusitis and tonsillitis/pharyngitis.

Streptococcus pneumoniae infections were present in 371 patients treated with Ketek, and in 86 patients who were treated in control arms with a comparator antibiotic. In Ketek-treated patients, 23.9 percent (89 of 371) had strains of Streptococcus pneumoniae which showed reduced susceptibility to penicillin and/or erythromycin, while in comparator-treated patients, 15.1 percent (13 of 86) of strains were resistant according to evaluations from a central laboratory.

Patients with penicillin and/or erythromycin resistant strains of Streptococcus pneumoniae showed higher clinical cure rates than those treated with a comparator antimicrobial (85.7 percent vs. 60.0 percent respectively; PPb population). Overall clinical cure rates in patients with these resistant strains of Streptococcus pneumoniae were considerably higher in patients treated with Ketek than in those treated with a comparator antimicrobial (91.8% vs. 70%; per-protocol population).

Contact: Liz Rickard

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