HOME >> BIOLOGY >> NEWS
Key Asthma And Allergy Molecule Pictured

In a finding that is expected to lead to the development of a new class of drugs for allergy and asthma sufferers, researchers at Northwestern University and Harvard Medical School have determined the precise shape of the receptor molecule that triggers the allergic response in the immune system.

The finding, reported in the Dec. 23 issue of the journal Cell, is the first structure reported for a member of this family of antibody receptor proteins. It was made by probing crystals of the receptor called the high-affinity immunoglobulin-E receptor with the extremely brilliant X-rays produced by the Advanced Photon Source synchrotron at Argonne National Laboratory in Illinois.

"We think this identifies the structure that all of the members of this antibody receptor family will have," says Theodore S. Jardetzky, the Northwestern X-ray crystallographer who led the study.

As a class, antibody receptors allow immune system cells to affix antibodies onto the cells' surface to act as antennas for antigens, or foreign triggering substances. When so triggered, the cells respond by unleashing a barrage of immune responses. In the case of allergy and asthma, the high-affinity immunoglobulin-E receptor on the surface of mast cells anchors immunoglobulin-E, an antibody that receives allergens and triggers the mast cells to produce histamine, leukotrienes and other broadly-acting effector substances that lead to the itching, sneezing and congestion of allergies -- and the life-threatening respiratory distress of asthma and anaphylactic shock.

Other members of the antibody receptor family are involved in tumor recognition, autoimmune diseases such as arthritis, and in normal immunity.

The IG-E receptor was of particular interest because an estimated 20 percent of the population suffers from allergies. Asthma afflicts 15 million people in the U.S. and causes 500,000 hospitalizations and 5,000 deaths each year. The National Institutes of Health estimate that di
'"/>

Contact: Bill Burton
b-burton@nwu.edu
847-491-3115
Northwestern University
22-Dec-1998


Page: 1 2 3

Related biology news :

1. Asthma could be several diseases masquerading as one
2. Asthma patients cautioned about melatonin
3. New genetic technique delivers knockout blow to Asthma Virus
4. Asthmatic blacks get less high-quality asthma care
5. Asthma-linked genes discovered at Berkeley lab
6. Study Suggests New Approach To Asthma
7. UCSF Team Identifies Two Key Molecules In Asthma; Important Finding For New Therapies That Treat Disease At Cell Level
8. House Dust Mite Busters No Good For Asthma Sufferers
9. Allergy And Asthma-Exaceberating Mites, Molds And Pollens On The Rise Due To El Niño . . . La Niña
10. Three-Dimensional Structure Of Human Lung Tryptase Determined, An Enzyme Involved In Allergic Asthma
11. Photocatalytic Air Cleaning System Promises To Help Allergy Sufferers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key Asthma And Allergy Molecule Pictured

(Date:11/3/2014)... , Nov. 3, 2014 Research and Markets ... "Cell Therapy - Technologies, Markets and Companies" to their ... therapy technologies and methods, which have already started to play ... cell transplantation is replacing the old fashioned bone marrow transplants. ... therapy is bound to become a part of medical practice. ...
(Date:11/2/2014)... Physics World , James Dacey explores the ways in ... take their innovations from the lab into the commercial ... all start-up companies as they move from prototype to ... main factors: physics-based inventions are usually far from market-ready ... be a lot more complicated than had been originally ...
(Date:10/31/2014)... HMS Center for Biomedical Informatics (CBMI) has received two ... infusion of support will enable the center to continue ... and the other involving new approaches to precision medicine. ... National Human Genome Research Institute and the National Institute ... Center for Excellence in Genomic Science, or CEGS. , ...
Breaking Biology News(10 mins):Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3The 'valley of death' facing physics start-ups 2Transforming 'big data' into knowledge 2Transforming 'big data' into knowledge 3
(Date:11/18/2014)... (PRWEB) November 18, 2014 Array Architects ... and design expertise to the nation's hospitals and health ... served by those dedicating their careers to the advancement ... respected contributor in her respective field, Laura Silvoy has ... at the 2014 Winter Simulation Conference. , Laura ...
(Date:11/18/2014)... Nov. 18, 2014  Great Basin Scientific, Inc. (NASDAQ: ... the management will host a conference call and webcast to ... on Thursday, Nov. 20, at 4:30 pm EST time. ... since the Company,s recent IPO and would like to provide ... said Ryan Ashton , President and Chief Executive Officer ...
(Date:11/17/2014)... 17, 2014 Soligenix, Inc. (OTCQB: SNGX) ... developing products that address unmet medical needs in ... today the formation of a Medical Advisory Board ... Company as it advances the Phase 3 clinical ... of cutaneous T-cell lymphoma (CTCL), a rare class ...
(Date:11/15/2014)... November 13, 2014 Collaborative Consulting, a ... were named one of the Boston Globe’s “Top Places ... Sized Businesses in Massachusetts to receive the honor. , ... who take care of their most valuable resource: the ... presented annually, and are based on an array of ...
Breaking Biology Technology:Array Healthcare Simulation Expert Slated to Speak at Winter Simulation Conference 2Great Basin Scientific Announces Conference Call to Provide Update on Corporate Progress 2Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 2Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 3Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 4Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 5Soligenix Announces Formation of Cutaneous T-Cell Lymphoma Medical Advisory Board 6Collaborative Consulting Honored with Boston Globe Top Places to Work 2014 2
Cached News: