Key Asthma And Allergy Molecule Pictured

In a finding that is expected to lead to the development of a new class of drugs for allergy and asthma sufferers, researchers at Northwestern University and Harvard Medical School have determined the precise shape of the receptor molecule that triggers the allergic response in the immune system.

The finding, reported in the Dec. 23 issue of the journal Cell, is the first structure reported for a member of this family of antibody receptor proteins. It was made by probing crystals of the receptor called the high-affinity immunoglobulin-E receptor with the extremely brilliant X-rays produced by the Advanced Photon Source synchrotron at Argonne National Laboratory in Illinois.

"We think this identifies the structure that all of the members of this antibody receptor family will have," says Theodore S. Jardetzky, the Northwestern X-ray crystallographer who led the study.

As a class, antibody receptors allow immune system cells to affix antibodies onto the cells' surface to act as antennas for antigens, or foreign triggering substances. When so triggered, the cells respond by unleashing a barrage of immune responses. In the case of allergy and asthma, the high-affinity immunoglobulin-E receptor on the surface of mast cells anchors immunoglobulin-E, an antibody that receives allergens and triggers the mast cells to produce histamine, leukotrienes and other broadly-acting effector substances that lead to the itching, sneezing and congestion of allergies -- and the life-threatening respiratory distress of asthma and anaphylactic shock.

Other members of the antibody receptor family are involved in tumor recognition, autoimmune diseases such as arthritis, and in normal immunity.

The IG-E receptor was of particular interest because an estimated 20 percent of the population suffers from allergies. Asthma afflicts 15 million people in the U.S. and causes 500,000 hospitalizations and 5,000 deaths each year. The National Institutes of Health estimate that di

Contact: Bill Burton
Northwestern University

Page: 1 2 3

Related biology news :

1. Asthma could be several diseases masquerading as one
2. Asthma patients cautioned about melatonin
3. New genetic technique delivers knockout blow to Asthma Virus
4. Asthmatic blacks get less high-quality asthma care
5. Asthma-linked genes discovered at Berkeley lab
6. Study Suggests New Approach To Asthma
7. UCSF Team Identifies Two Key Molecules In Asthma; Important Finding For New Therapies That Treat Disease At Cell Level
8. House Dust Mite Busters No Good For Asthma Sufferers
9. Allergy And Asthma-Exaceberating Mites, Molds And Pollens On The Rise Due To El Niño . . . La Niña
10. Three-Dimensional Structure Of Human Lung Tryptase Determined, An Enzyme Involved In Allergic Asthma
11. Photocatalytic Air Cleaning System Promises To Help Allergy Sufferers

Post Your Comments:

(Date:11/17/2015)... -- Paris , qui s,est ... Paris , qui s,est tenu du 17 ... de l,innovation biométrique, a inventé le premier scanner couplé, ... la même surface de balayage. Jusqu,ici, deux scanners étaient ... empreintes digitales. Désormais, un seul scanner est en mesure ...
(Date:11/17/2015)... 2015 Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" ... sale of broadly enabling, pressure cycling technology ("PCT")-based sample ... announced it has received gross proceeds of $745,000 from ... (the "Offering"), increasing the total amount raised to date ... closings are expected in the near future. ...
(Date:11/12/2015)... , Nov. 12, 2015  A golden retriever that ... muscular dystrophy (DMD) has provided a new lead for ... Hospital, the Broad Institute of MIT and Harvard and ... . Cell, pinpoints a ... "escape" the disease,s effects. The Boston Children,s lab of ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... -- TapImmune, Inc. (TPIV), a clinical-stage ... and gene-based immunotherapeutics and vaccines for the treatment of ... presenting at the 8 th Annual LD Micro ... PT. Dr. John N. Bonfiglio a TapImmune ... presentation and will join TapImmune management in meeting with ...
(Date:11/30/2015)... 30, 2015  HUYA Bioscience International, the leader in ... pharmaceutical innovations, today announced it has signed a Memorandum ... to foster collaboration between KDDF and HUYA with the ... healthcare products for the global market. ... of new innovative preclinical and clinical stage compounds. The ...
(Date:11/30/2015)... 30, 2015  Aytu BioScience, Inc. (OTCQB: AYTU), a ... conditions, will present at two upcoming investor conferences. Aytu ... real-time virtual conference, to be held December 3, 2015, ... be held December 2 nd & 3 rd ... and streamed live via webcast. Josh Disbrow ...
(Date:11/30/2015)... 30, 2015  AbbVie, is introducing Good Morning ... a daily routine for managing the life-long condition of ... affect the way the body absorbs it so resources ... daily routine are important. The goal of the new ... manage their hypothyroidism by establishing a daily routine, spirit ...
Breaking Biology Technology:
Cached News: