Key Peptides Found That Stop -- Even Reverse -- Kidney Disease In Lupus

CHICAGO --- Northwestern University Medical School researchers have identified key peptides -- small bits of proteins -- that halt kidney disease in lupus, an autoimmune disease that attacks the body's own DNA.

In an article in the May 15 issue of the Journal of Immunology, Syamal Datta, M.D., the Solovy Arthritis Research Society Professor, and colleagues at Northwestern reported that brief therapy with the peptides in young, lupus-prone mice markedly delayed the onset of severe, lupus-related kidney disease. Long-term therapy with the peptides in adult mice with established kidney disease prolonged survival and even stopped progression of their disease.

Remarkably, one of the peptides, called H4 16-39, not only arrested but reversed kidney disease in the mice and allowed them to live almost a normal lifespan.

Datta's group used a special method of administering the peptides in a soluble, high-dose form -- a technique called tolerization -- to induce tolerance or inactivate disease-causing T helper cells and B cells. T helper and B cells are the mediators of the body's immune response.

Interestingly, the most effective peptide, H4 16-39, inhibited function of lupus nephritis-causing T helper and B cells because it contains molecules (epitopes) on its surface that are "recognized" by both cell types.

The normal immune system produces antibodies and T helper cells in response to invading antigens, e.g., toxins, foreign proteins or whole organisms, such as bacteria or viruses. Portions of the foreign protein molecules are recognized by the antibody receptor and the T helper cell receptor molecules on infection-fighting T and B cells. In response, B cells -- with the help of the T cells -- produce antibodies to wipe out the invaders.

Datta had earlier discovered that in lupus, specific T helper cells react to nucleosomes, a complex of DNA and histone proteins that forms a cell's nuclear

Contact: Elizabeth Crown
Northwestern University

Page: 1 2

Related biology news :

1. Peptides Implicated In Bodys Response To Pain
2. Brown ecologist garners major National Science Foundation grant
3. APS Foundation names student travel award recipients
4. Institute for OneWorld Health receives Gates Foundation grant
5. National Parkinson Foundation designates UNC as Center of Excellence
6. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
7. Betty Ann Forbes wins 2004 ASM Founders Award
8. Leslie Ann Schiff wins 2004 Carski Foundation Award
9. Grant from GE Foundation to University of Houston to strengthen math, tech pipeline
10. National Foundation For Cancer Research names UCSDs Webster Cavenee NFCR Fellow
11. Founder of UCSD bioengineering program honored with lifetime achievement award

Post Your Comments:

(Date:8/26/2020)... ... August 24, 2020 , ... Elgia Therapeutics , ... fibrotic diseases, today announced that Dr. Stacie Canan has joined the company as ... previously served as Executive Director of Global Health at Bristol Myers Squibb (formerly ...
(Date:8/23/2020)... , ... August 21, 2020 , ... ... Corporation has been published and is now available on the company’s global ... diffraction—serves the X-ray analysis community, presenting current news and crystallographic research. , ...
(Date:8/21/2020)... ... August 20, 2020 , ... NDA ... , a Clinical Operations executive with expertise in clinical trial planning and feasibility, ... as an Expert Consultant. Throughout his career, Mr. Movahhed has helped design and ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... TORONTO (PRWEB) , ... July 16, 2020 , ... After ... begins. The completion of a great surgery is only the beginning of a successful ... the research community. , Join Brad Gien, Global Head of Surgery from Envigo ...
(Date:7/10/2020)... ... July 09, 2020 , ... PathSensors Inc., ... has expanded the company’s exclusive license to include clinical applications for CANARY™ ... market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ fast and highly ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , ... in 2020, despite many obstacles created as a result of COVID-19. As a ... its partnered medical practices and medical manufacturers by expanding access to device offerings, ...
(Date:6/28/2020)... ROCKY HILL, Conn. (PRWEB) , ... June 25, ... ... systems company formed to advance photodynamic therapy for treating cancer, today announced the ... Buffalo, New York (“Roswell Park”). The agreement provides Lumeda globally exclusive rights ...
Breaking Biology Technology:
Cached News: