Key gene in orchestrating embryo development also fine tunes organization of the retina

(MEMPHIS, TENN.--May 1, 2003) Investigators at St. Jude Children's Research Hospital have discovered that a gene called Prox1 turns on and off at two different times during the embryonic retina development. This discovery offers important evidence of how such a complex tissue can grow from populations of cells that initially have no special function.

The finding is important because it demonstrates that this single gene can perform two different functions during the embryonic retina development, according to Michael Dyer, Ph.D., an assistant member of the St. Jude Department of Developmental Neurobiology. Dyer is the lead author of a report on this work that appears in the May issue of Nature Genetics.

"The critical role we found for Prox1 in the retina supports a growing body of evidence we've been accumulating in the past few years indicating that Prox1 is a key player in orchestrating the proper development of the entire embryo," said Guillermo Oliver, Ph.D., an associate member of the St. Jude Department of Genetics and co-author of the paper.

Using a laboratory mouse model lacking the Prox1 gene, the researchers initially found that the gene was necessary for proper development of a layer of cells in the retina called horizontal cells. These cells process information sent by light-sensitive cells called rods. In the absence of Prox1, this layer was abnormally expanded with cells that had not become specialized into horizontal cells.

Researcher used a variety of techniques including radioactive tags to track newly produced DNA in dividing cells, DNA microarrays to identify differentially affected genes and specially engineered viruses to deliver Prox1 into retinal cells.

Results of these studies also showed that the control Prox1 exerts over the developing retina is so precise that it also ensures that there is one horizontal cell for every 150 rods.

"We found that Prox1 directs progenitor cells that will become

Contact: Bonnie Cameron
St. Jude Children's Research Hospital

Page: 1 2

Related biology news :

1. Sequential signals choreograph embryonic tubule formation
2. Therapeutic cloning no longer a dream, says scientist who produced first cloned embryonic stem cell
3. Conflicting views on embryonic and adult stem cells complicate research in stem cell therapeutics
4. MIT technology jump-starts human embryonic stem cell work
5. Genetic testing of embryos to pick savior sibling OK with most Americans
6. Researchers model embryo implantation and tumour metastasis in fruit flies
7. New human embryonic stem-cell lines to be made available to researchers
8. Most clones doomed from the start, according to Temple University embryologist
9. Jefferson researchers uncover biochemical clues to how cells migrate in embryos
10. Human embryonic stem cells may promise medical advances
11. Destructive wizardry of Ozz-E3 ligase appears key to building skeletal muscles in embryos and adults

Post Your Comments:

(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners ... a Clinical Operations executive with expertise in clinical trial planning and feasibility, regulatory ... an Expert Consultant. Throughout his career, Mr. Movahhed has helped design and manage ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... in the prestigious National STEM Scholar Program, a unique professional development program that ... project support for middle school science teachers nationwide. , Created in partnership between ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... product portfolio with a near term focus on Type 2 diabetes and associated ... experience across multiple therapeutic areas and classes. As Chief Commercial Officer, Justin will ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... SHREWSBURY, Mass. (PRWEB) , ... July 29, 2020 ... ... clad wire that can combine up to three different materials for use with ... can combine up to three materials to meet specific design requirements, performance, and ...
(Date:7/31/2020)... ... 2020 , ... The SDX® Respiratory Gating System , ... reached its 20th anniversary of worldwide use. Introduced in the US over the ... University of Pennsylvania, University of Michigan, University of Maryland, University of California San ...
(Date:7/18/2020)... , ... July 16, 2020 , ... After research model ... completion of a great surgery is only the beginning of a successful study, while ... community. , Join Brad Gien, Global Head of Surgery from Envigo in ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a ... and food industries, is pleased to announce that Charles Galea has joined its ... , Charles is an accomplished and results-driven sales executive with over 10 years ...
Breaking Biology Technology:
Cached News: