HOME >> BIOLOGY >> NEWS
Key regulatory enzyme is a molecular 'octopus'

DURHAM, N.C. -- After seven years of work, researchers have succeeded in deducing the three-dimensional structure of an elusive and complex protein enzyme that is central to regulating the body's largest family of receptors. These receptors, called G-protein-coupled receptors, nestle in the cell membrane and respond to external chemical signals such as hormones and neurotransmitters, to switch on cell machinery.

The thousands of such receptors throughout the body play a fundamental role in the mechanisms of sight, smell and taste, and in regulating heart rate, blood pressure and glucose metabolism. The receptors are by far the most common target for drugs that affect cardiac output, blood pressure and many other physiological functions. Thus, said the researchers, their fundamental discovery could guide pharmaceutical companies in creating a new class of drugs that aim not at blocking the receptors themselves, but at modulating the machinery that regulates them. Such drugs could treat a range of disorders from congestive heart failure to Parkinson's disease, they said.

The newly revealed structure of this receptor "off-switch" -- called a G protein-coupled receptor kinase (GRK) -- reveals the protein as the molecular equivalent of a three-armed octopus, with independent segments capable of performing multiple regulatory functions at once. Kinases are enzymes that act as molecular switches by adding phosphates to other proteins.

The researchers -- led by Howard Hughes Medical Institute investigator Robert Lefkowitz at Duke University Medical Center and John Tesmer of the University of Texas at Austin -- reported their findings in the May 23, 2003, issue of the journal Science. The team also included scientists from the University of Texas at Austin and University College London. Also on the research team was Darrell Capel of Duke.

"Fundamental to the regulation of all these receptors is the ability to damp their signaling in the face
'"/>

Contact: Dennis Meredith
dennis.meredith@duke.edu
919-681-8054
Duke University
19-Jun-2003


Page: 1 2 3

Related biology news :

1. Significant strides in small regulatory RNA research in plants
2. Pew report finds GM insects may offer benefits, but clear regulatory oversight is lacking
3. Researchers discover genes that control regulatory functions in malaria mosquitoes
4. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
5. First glimpse of DNA binding to viral enzyme
6. Two enzymes key to calorie-burning, Brown research shows
7. Argonne scientists determine structure of staph, anthrax enzyme
8. Brain serotonin enzyme finding might explain psychiatric disorders
9. Study finds plant enzyme function changes with location in cell
10. Basic RNA enzyme research promises single-molecule biosensors
11. Molecule that blocks key bacterial enzyme may lead to new antibiotics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... , ... July 09, 2020 , ... Today CJ BIO ... which will share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, ... Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM (CDT) during ...
(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, a ... purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga prefecture ... facility located in Kakegawa, the new 60,000-square-foot facility will provide customers with flexible ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC , ... that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) ... with severe COVID-19. This is the first study of an XPO1 inhibitor in ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... In ... commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to ... by Dr MA has been using the zebrafish model to investigate the causes ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World ... Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, ... an elite awards program, highlighting outstanding examples of how technology innovations and strategic ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... the launch of a new clinical diagnostics immuno-oncology service, TissueInsight . ... (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
Breaking Biology Technology:
Cached News: