HOME >> BIOLOGY >> NEWS
Key regulatory enzyme is a molecular 'octopus'

DURHAM, N.C. -- After seven years of work, researchers have succeeded in deducing the three-dimensional structure of an elusive and complex protein enzyme that is central to regulating the body's largest family of receptors. These receptors, called G-protein-coupled receptors, nestle in the cell membrane and respond to external chemical signals such as hormones and neurotransmitters, to switch on cell machinery.

The thousands of such receptors throughout the body play a fundamental role in the mechanisms of sight, smell and taste, and in regulating heart rate, blood pressure and glucose metabolism. The receptors are by far the most common target for drugs that affect cardiac output, blood pressure and many other physiological functions. Thus, said the researchers, their fundamental discovery could guide pharmaceutical companies in creating a new class of drugs that aim not at blocking the receptors themselves, but at modulating the machinery that regulates them. Such drugs could treat a range of disorders from congestive heart failure to Parkinson's disease, they said.

The newly revealed structure of this receptor "off-switch" -- called a G protein-coupled receptor kinase (GRK) -- reveals the protein as the molecular equivalent of a three-armed octopus, with independent segments capable of performing multiple regulatory functions at once. Kinases are enzymes that act as molecular switches by adding phosphates to other proteins.

The researchers -- led by Howard Hughes Medical Institute investigator Robert Lefkowitz at Duke University Medical Center and John Tesmer of the University of Texas at Austin -- reported their findings in the May 23, 2003, issue of the journal Science. The team also included scientists from the University of Texas at Austin and University College London. Also on the research team was Darrell Capel of Duke.

"Fundamental to the regulation of all these receptors is the ability to damp their signaling in the face
'"/>

Contact: Dennis Meredith
dennis.meredith@duke.edu
919-681-8054
Duke University
19-Jun-2003


Page: 1 2 3

Related biology news :

1. Significant strides in small regulatory RNA research in plants
2. Pew report finds GM insects may offer benefits, but clear regulatory oversight is lacking
3. Researchers discover genes that control regulatory functions in malaria mosquitoes
4. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
5. First glimpse of DNA binding to viral enzyme
6. Two enzymes key to calorie-burning, Brown research shows
7. Argonne scientists determine structure of staph, anthrax enzyme
8. Brain serotonin enzyme finding might explain psychiatric disorders
9. Study finds plant enzyme function changes with location in cell
10. Basic RNA enzyme research promises single-molecule biosensors
11. Molecule that blocks key bacterial enzyme may lead to new antibiotics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: