HOME >> BIOLOGY >> NEWS
Ki-67 biomarker a strong predictor of outcome for prostate cancer patients

SALT LAKE CITY, UTAH--The largest known biomarker study for prostate cancer patients treated with radiation therapy shows that the presence Ki-67 may be a significant predictor of patient outcome for men with prostate cancer treated with both radiation and hormones. The study was sponsored by the Radiation Therapy Oncology Group and was presented today by Alan Pollack, M.D., Ph.D., chairman of radiation oncology at Fox Chase Cancer Center, at the 45th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Salt Lake City, Utah.

The Ki-67 biomarker is a proliferation antigen that is detected by a process called immunohistochemical staining. When a tumor cell tests positive for Ki-67, the tumor is actively growing.

Prostate cancers typically have very low percentages of growing cells and they grow slowly. Pollack and others have previously shown in smaller studies that the greater the proportion of prostate tumor cells with Ki-67, the more aggressive the cancer. Prior studies involved small patient numbers and did not definitively establish the usefulness of the Ki-67 biomarker.

"Our study conclusively shows that Ki-67 was the most significant determinant of distant metastasis and death in prostate cancer patients," explained Pollack. "The relationship of Ki-67 to patient outcome is a continuous function, wherein the higher the percent of Ki-67, the greater the risk of an adverse result. In addition, Ki-67, along with PSA, Gleason score and stage, appears to be valuable in determining whether high-risk patients may be spared long-term androgen deprivation."

Pollack says that a consistent threshold for the application of Ki-67 on a routine basis has not been previously established. In this study, when greater than 7.1% of the tumor cells stained for Ki-67, there was a significantly increased risk of distant metastasis and death due to prostate cancer.

Furthermore, Pollack adds, Ki-67 should be very usef
'"/>

Contact: Karen Carter Mallet
k_carter@fccc.edu
215-728-2700
Fox Chase Cancer Center
21-Oct-2003


Page: 1 2

Related biology news :

1. New drug target and biomarker for advanced childhood cancer discovered
2. Protein biomarkers accurately and quickly diagnose ALS, find Pittsburgh researchers
3. Illinois study seeking biomarkers of canine diabetes, other diseases
4. Cyclacels biomarker technology shows that CYC202 induces cancer cells to commit suicide
5. Oral contraceptives increase C-reactive protein, an infIammatory biomarker
6. Promising biomarker for melanoma is identified
7. UC Davis M.I.N.D. Institute launches new program to identify biomarkers for autism and other disorders
8. When suns too strong, plankton make clouds
9. Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
10. Clinical judgement still counts strongly alongside genetic testing
11. Food tastes stronger when youre hungry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/29/2020)... STATE COLLEGE, Pa. (PRWEB) , ... January 29, ... ... leader in nuclear receptor and in vitro toxicology testing solutions, has announced a ... Shareholders in the upcoming weeks, INDIGO showed more than a twenty percent increase ...
(Date:1/28/2020)... ... 2020 , ... Blue Health Intelligence (BHI) published an article ... and limit the utilization of high-cost imaging and surgeries for musculoskeletal (MSK) injuries. ... specializes in improving care delivery for MSK conditions. In an independent study using ...
(Date:1/24/2020)... ... ... Shoreline Biome , a microbiome research company that develops tools for characterizing ... a novel new DNA isolation kit at the Miami Winter Symposium 2020 , ... is a fast and easy-to-use kit designed for the efficient and unbiased isolation of ...
Breaking Biology News(10 mins):
(Date:2/13/2020)... , ... February 12, 2020 , ... ... pharmacovigilance (PV) solutions and services, is adopting Veeva Vault Safety™ as ... a requirement for fast assessment of data, processing of safety information such as ...
(Date:2/5/2020)... ... February 05, 2020 , ... Rare Disease Day® , held the ... Organization for Rare Disorders (NORD), to raise awareness amongst the general public and decision-makers ... Balancing Act’s “Behind The Mystery” rare disease series will be shining the ...
(Date:1/28/2020)... ... January 28, 2020 , ... Today, Salimetrics ... . The new Salivary Total Human IgG Assay Kit exemplifies Salimetrics’ ... in saliva, researchers can extend the accuracy and ease of use of salivary ...
(Date:1/24/2020)... ... 2020 , ... Sierra Instruments, global leader in mass flow, ... ideal for BioPharm OEMS. Sierra also announces RedyCompact™ flow meters and ... high-precision MEMS (Micro-Electro Mechanical Systems) technology utilizing an advanced, ultra-stable no-drift CMOS (Complementary ...
Breaking Biology Technology:
Cached News: