HOME >> BIOLOGY >> NEWS
Kidney injury's harmful effects on bones blocked in mice

St. Louis, February 6, 2004 -- Scientists working with a mouse model of chronic kidney disease have found a treatment that appears to block the devastating effects kidney damage can have on bones.

"We still have some mechanical and structural testing to do to prove that the skeletons of these mice are normal, but if this works out and we're able to apply it in humans, we could be on our way to producing a major improvement in the well-being of patients with chronic kidney disease," says Keith A. Hruska, M.D., the Ira M. Lang Professor of Nephrology and professor of pediatrics and of cell biology and physiology at Washington University School of Medicine in St. Louis.

Hruska was principal investigator for the study, which appears in the February issue of the Journal of the American Society for Nephrology. Scientists gave injections of bone morphogenetic protein-7 (BMP-7), a protein involved in both bone and kidney growth, to mice with damaged and removed kidneys. The injections prevented a condition known as adynamic bone disorder (ABD) that leads to weakening and distortion of bone.

"Adynamic bone disorder means that the cells that remodel bones are markedly diminished in number and activity," Hruska explains. "In the past, the skeleton has been viewed as a mostly dead structure, but that's not the case at all. The adult skeleton is a very active tissue that is continually remodeling."

ABD is the second type of bone weakening related to kidney problems that scientists have identified. In the first, secondary hyperparathyroidism, patients have weakened bones like in ABD, but also have abnormal blood levels of the hormone produced by the parathyroid gland and several other important chemicals.

Hruska suspects secondary hyperparathyroidism may be a failed attempt to compensate for ABD, which first emerged about 15 years ago when scientists began using drugs to suppress parathyroid hormone levels in kidney patients.

Second
'"/>

Contact: Michael C. Purdy
purdym@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
6-Feb-2004


Page: 1 2 3

Related biology news :

1. Key Peptides Found That Stop -- Even Reverse -- Kidney Disease In Lupus
2. A Versatile Signal In Vertebrate Embryogenesis: Wnt-4 Regulates Kidney Development, Sex Organ Differentiation, Neuronal Survival And Axonal Guidance
3. Cells From Mother Can Boost Success Of Sibling-To-Sibling Kidney Transplants
4. University Of Texas Southwestern Researchers Develop New Test For Kidney Function
5. Lack Of Intestinal Bacterium Linked To Kidney Stones In Cystic Fibrosis Patients, University Of Florida Researchers Report
6. Little Known Protein Prevents Formation Of Kidney Stones In Trace Amounts
7. Researchers Discover Way To Grow New Kidneys In Rats
8. Low-Protein Diet May Reverse Kidney Disease
9. Excess thyroid hormone harmful to fetus
10. Figs may inhibit growth and survival of harmful microbes in food
11. Study of Cape Cod Seashore finds off-road vehicles harmful to beach fauna

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... 2020 , ... Accumen Inc. is helping healthcare get better, ... Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has been ... 10 years. Early in the COVID-19 crisis, we identified supply chain gaps and ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/4/2020)... , ... July 03, 2020 , ... ... to earn outstanding recognition and multiple awards for not only the products and ... portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built by ABM ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... , ... July 22, 2020 , ... Join experts from ... Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar on ... regulating body in China for drugs and medical devices. Specifically, for medical devices, the ...
(Date:7/18/2020)... ... , ... dicentra , a leading Contract Research Organization ... pleased to announce that Charles Galea has joined its clinical trials division as ... accomplished and results-driven sales executive with over 10 years of expertise in business ...
(Date:7/10/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will join ... Dr. Nissenson serves as an Emeritus Professor of Medicine at the David ...
(Date:7/1/2020)... ... 29, 2020 , ... The Interlocal Purchasing System (TIPS), a ... recently named BioFit Engineered Products an Awarded Vendor. Awarded Vendor status ... cafeteria tables, book trucks and carts at discounted pricing without the delay and ...
Breaking Biology Technology:
Cached News: