HOME >> BIOLOGY >> NEWS
Kidney injury's harmful effects on bones blocked in mice

St. Louis, February 6, 2004 -- Scientists working with a mouse model of chronic kidney disease have found a treatment that appears to block the devastating effects kidney damage can have on bones.

"We still have some mechanical and structural testing to do to prove that the skeletons of these mice are normal, but if this works out and we're able to apply it in humans, we could be on our way to producing a major improvement in the well-being of patients with chronic kidney disease," says Keith A. Hruska, M.D., the Ira M. Lang Professor of Nephrology and professor of pediatrics and of cell biology and physiology at Washington University School of Medicine in St. Louis.

Hruska was principal investigator for the study, which appears in the February issue of the Journal of the American Society for Nephrology. Scientists gave injections of bone morphogenetic protein-7 (BMP-7), a protein involved in both bone and kidney growth, to mice with damaged and removed kidneys. The injections prevented a condition known as adynamic bone disorder (ABD) that leads to weakening and distortion of bone.

"Adynamic bone disorder means that the cells that remodel bones are markedly diminished in number and activity," Hruska explains. "In the past, the skeleton has been viewed as a mostly dead structure, but that's not the case at all. The adult skeleton is a very active tissue that is continually remodeling."

ABD is the second type of bone weakening related to kidney problems that scientists have identified. In the first, secondary hyperparathyroidism, patients have weakened bones like in ABD, but also have abnormal blood levels of the hormone produced by the parathyroid gland and several other important chemicals.

Hruska suspects secondary hyperparathyroidism may be a failed attempt to compensate for ABD, which first emerged about 15 years ago when scientists began using drugs to suppress parathyroid hormone levels in kidney patients.

Second
'"/>

Contact: Michael C. Purdy
purdym@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
6-Feb-2004


Page: 1 2 3

Related biology news :

1. Key Peptides Found That Stop -- Even Reverse -- Kidney Disease In Lupus
2. A Versatile Signal In Vertebrate Embryogenesis: Wnt-4 Regulates Kidney Development, Sex Organ Differentiation, Neuronal Survival And Axonal Guidance
3. Cells From Mother Can Boost Success Of Sibling-To-Sibling Kidney Transplants
4. University Of Texas Southwestern Researchers Develop New Test For Kidney Function
5. Lack Of Intestinal Bacterium Linked To Kidney Stones In Cystic Fibrosis Patients, University Of Florida Researchers Report
6. Little Known Protein Prevents Formation Of Kidney Stones In Trace Amounts
7. Researchers Discover Way To Grow New Kidneys In Rats
8. Low-Protein Diet May Reverse Kidney Disease
9. Excess thyroid hormone harmful to fetus
10. Figs may inhibit growth and survival of harmful microbes in food
11. Study of Cape Cod Seashore finds off-road vehicles harmful to beach fauna

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... Lajollacooks4u is delighted to announce it ... which honors hospitality excellence, is given only to businesses that have achieved consistently outstanding ... consecutive years. , To qualify for the Certificate of Excellence –- an ...
(Date:6/1/2019)... ... May 31, 2019 , ... The University ... recently invested in BioFactura’s $6M Series B Financing Round. , “With the ... investors who bring significant financial and business resources to bear as we advance ...
(Date:5/31/2019)... ... May 30, 2019 , ... Researchers from Ambry ... documented significant differences in the prevalence of hereditary genetic mutations, also called germline ... White women. Results will be presented at the 2019 American Society of Clinical ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... California (PRWEB) , ... May ... ... of our patent applications from the USPTO providing proprietary interest to our ... METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including ...
(Date:5/22/2019)... ... 2019 , ... Artemis (formerly Agrilyst), the leading enterprise Cultivation Management ... co-led by Astanor Ventures and Talis Capital with participation from ... Fund . The company has raised $11.75m to date and will use the new ...
(Date:5/14/2019)... ... May 13, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is ... redesigned website aims to improve LDA’s ability to communicate directly with the marketplace; ...
(Date:5/4/2019)... Brazil (PRWEB) , ... May 03, 2019 , ... ... given by the President of the Dakila Pesquisas Association, the scientist and ufologist ... Councilmen 2019, in Brasília (DF). Urandir detailed the results of some research carried ...
Breaking Biology Technology:
Cached News: