HOME >> BIOLOGY >> NEWS
Kidney injury's harmful effects on bones blocked in mice

St. Louis, February 6, 2004 -- Scientists working with a mouse model of chronic kidney disease have found a treatment that appears to block the devastating effects kidney damage can have on bones.

"We still have some mechanical and structural testing to do to prove that the skeletons of these mice are normal, but if this works out and we're able to apply it in humans, we could be on our way to producing a major improvement in the well-being of patients with chronic kidney disease," says Keith A. Hruska, M.D., the Ira M. Lang Professor of Nephrology and professor of pediatrics and of cell biology and physiology at Washington University School of Medicine in St. Louis.

Hruska was principal investigator for the study, which appears in the February issue of the Journal of the American Society for Nephrology. Scientists gave injections of bone morphogenetic protein-7 (BMP-7), a protein involved in both bone and kidney growth, to mice with damaged and removed kidneys. The injections prevented a condition known as adynamic bone disorder (ABD) that leads to weakening and distortion of bone.

"Adynamic bone disorder means that the cells that remodel bones are markedly diminished in number and activity," Hruska explains. "In the past, the skeleton has been viewed as a mostly dead structure, but that's not the case at all. The adult skeleton is a very active tissue that is continually remodeling."

ABD is the second type of bone weakening related to kidney problems that scientists have identified. In the first, secondary hyperparathyroidism, patients have weakened bones like in ABD, but also have abnormal blood levels of the hormone produced by the parathyroid gland and several other important chemicals.

Hruska suspects secondary hyperparathyroidism may be a failed attempt to compensate for ABD, which first emerged about 15 years ago when scientists began using drugs to suppress parathyroid hormone levels in kidney patients.

Second
'"/>

Contact: Michael C. Purdy
purdym@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
6-Feb-2004


Page: 1 2 3

Related biology news :

1. Key Peptides Found That Stop -- Even Reverse -- Kidney Disease In Lupus
2. A Versatile Signal In Vertebrate Embryogenesis: Wnt-4 Regulates Kidney Development, Sex Organ Differentiation, Neuronal Survival And Axonal Guidance
3. Cells From Mother Can Boost Success Of Sibling-To-Sibling Kidney Transplants
4. University Of Texas Southwestern Researchers Develop New Test For Kidney Function
5. Lack Of Intestinal Bacterium Linked To Kidney Stones In Cystic Fibrosis Patients, University Of Florida Researchers Report
6. Little Known Protein Prevents Formation Of Kidney Stones In Trace Amounts
7. Researchers Discover Way To Grow New Kidneys In Rats
8. Low-Protein Diet May Reverse Kidney Disease
9. Excess thyroid hormone harmful to fetus
10. Figs may inhibit growth and survival of harmful microbes in food
11. Study of Cape Cod Seashore finds off-road vehicles harmful to beach fauna

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... ... August 13, 2018 , ... ... Staticmaster® P-2021-5502 and P-2021-5602 Cleanroom Ionizing Gun. , The ionizing gun features ... Gun, P-2021 ionizing cartridge, 0.5-micron filter and electropolished OSHA-compliant tip. This can be ...
(Date:8/9/2018)... ... August 08, 2018 , ... ... and marketing companies, who helps physicians bring the latest regenerative therapies and treatment ... and Saturday, October 5-6, 2018 in White Plains, NY. , The ...
(Date:8/7/2018)... ... 06, 2018 , ... BioMedGPS announces the launch of SmartTRAK ... its medical device customers, BioMedGPS teamed up with a usability expert to help ... 3.0 touts a cleaner look, easier navigation and improved functionality. , SmartTRAK ...
Breaking Biology News(10 mins):
(Date:8/11/2018)... ... 2018 , ... Researchers performing pressurized NMR or EPR experiments face a danger ... for High-Pressure NMR & EPR by Wilmad-LabGlass – SP Scienceware shields researchers from ... High-pressure experiments have significantly grown in popularity over the last several years. As a ...
(Date:8/9/2018)... ... August 08, 2018 , ... ... was developed and is continually updated by a talented scientific team that includes ... service provides: , 1. Information on the medical impact of a patient’s ...
(Date:8/9/2018)... ... August 08, 2018 , ... Since their establishment in 2012, ambitions have ... team nearly double its’ size from last year, the company is thrilled to announce ... heads and impressed crowds at a private product launch event during the annual Protein ...
(Date:8/9/2018)... ... August 09, 2018 , ... Rockland Immunochemicals, Inc. announced ... Aggeler, Director of Antibody Development at Bio-Techne, composed a peer-reviewed article using their ... on August 9, 2018 and will be printed in the September 2018 issue ...
Breaking Biology Technology:
Cached News: