HOME >> BIOLOGY >> NEWS
Knocking out SHIP gene improves success of allogeneic bone marrow transplants in mice

uch as the SHIP gene, would give us a novel and more selective approach for preventing and treating graft-versus-host disease." said Karen Fields MD, professor of medicine and oncology at USF and director of the Bone Marrow Transplant Program at Moffitt Cancer Center.

While graft-versus-host disease is largely treatable, the immunosuppressive drugs administered for it create serious side effects for patients. In fact, graft-versus-host disease and its consequences remain the number one cause of death following transplant.

Bone marrow transplant rejection is rare when the person donating the bone marrow or stem cells is a genetically matched family member, most often a sibling. However, the chances of rejection increase if the donor is unrelated to the patient and the tissue is incompletely matched. Despite the increasing number of bone marrow transplants performed, more than 75 percent of patients who need an allogeneic transplant each year go without one because a suitable bone marrow cannot be found.

The pool of available donors would increase significantly if Dr. Kerr's SHIP gene finding holds true in humans, because less well-matched grafts could be tolerated as transplants, Dr. Fields said.

Widely used in the treatment of blood cell cancers, bone marrow transplants from healthy donors help restore the cancer patient's blood system following its destruction by chemotherapy and radiation. The immune cells in these transplants may also attack lingering cancer cells that remain in the body following chemotherapy and radiation, thereby increasing the patient's chances for disease-free survival.


'"/>

Contact: Anne DeLotto Baier
abaier@hsc.usf.edu
813-974-3300
University of South Florida Health
14-Mar-2002


Page: 1 2

Related biology news :

1. Knocking the Sox off early mammalian development
2. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
3. Study shows that ultrasound accreditation improves the quality of ultrasound practice
4. Small trial shows daclizumab add-on therapy improves MS outcome
5. Combination therapy dramatically improves function after spinal cord injury in rats
6. Moderate iron deficiency affects cognitive performance - but iron supplementation improves it
7. Longer-term, moderate exercise improves immune activity
8. New approach limits damage after heart attack and improves survival, say Scripps Research scientists
9. Online calculator improves analysis of chemical data
10. Dec. 17 JAMA study shows new biologic drug reduces psoriasis symptoms, improves quality of life
11. Standard improves tests of male DNA

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/24/2017)... 2017 The Controller General of Immigration from Maldives ... Algeen have received the prestigious international IAIR Award for the most ... Reading ... Maldives ... Abdulla Algeen (small picture on the right) have received the IAIR award ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... The Blavatnik ... Winners and six Finalists of the 2017 Blavatnik Regional Awards for Young Scientists. ... Foundation and administered by the New York Academy of Sciences to honor the ...
(Date:10/12/2017)... CA (PRWEB) , ... October ... ... (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform specifically designed ... bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, who made ...
(Date:10/11/2017)... Md. (PRWEB) , ... October 11, 2017 , ... ... digital pathology, announced today it will be hosting a Webinar titled, “Pathology is ... Advanced Pathology Associates , on digital pathology adoption best practices and how Proscia ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh ... orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of ... SBT-100 is able to cross the cell membrane and bind intracellular STAT3 and ...
Breaking Biology Technology:
Cached News: