HOME >> BIOLOGY >> NEWS
Knocking the Sox off early mammalian development

Scientists have identified a gene that is required during early mammalian embryogenesis to maintain cellular pluripotency the ability of an embryonic cell to develop into virtually any cell type of the adult animal. This discovery by Dr. Robin Lovell-Badge and colleagues at the MRC National Institute for Medical Research (London, UK) that the Sox2 gene is necessary to sustain the developmental plasticity of embryonic cells sheds new light on the molecular cues that direct early embryogenesis, as well as the genetic requirements for embryonic stem cell maintenance. The report is published in the January 1 issue of Genes & Development.

"Stem cells must have specific genes that give them their characteristic properties. Our work describes one such gene, Sox2, that appears essential for multipotent stem cell types in the early embryo," explains Dr. Lovell-Badge.

Early in mammalian development, a pre-implantation stage embryo called a blastocyst forms. The cells of the blastocyst are at a developmental fork in the road: The cells on the surface of the blastocyst become trophoblast cells, while the cells on the inside of the blastocyst become the inner cell mass (ICM). The ICM is further specified into epiblast and hypoblast cells, which, together with trophoblast cells, give rise to the entire embryo and its associated tissues: epiblast cells differentiate into all the cell types of the embryo, hypoblast cells differentiate into the yolk sac, and trophoblast cells differentiate into the chorion and much of the placenta, including a range of specialized cell types.

Dr. Lovell-Badge and colleagues have identified Sox2 as one of the only two known transcription factors (master gene regulators) to be involved in the specification of these three embryonic cell lineages.

"We have been working with this gene for a while, using it, for example, to study stem cells of the nervous system, and simply set out to ask what its critical role is during
'"/>

Contact: Heather Cosel
coselpie@cshl.org
Cold Spring Harbor Laboratory
31-Dec-2002


Page: 1 2

Related biology news :

1. Knocking out SHIP gene improves success of allogeneic bone marrow transplants in mice
2. Chemical derived from vitamin-E shows early promise as cancer drug
3. Phase II trials of second-generation antisense cancer drug planned following successful early study
4. The impact of genetic variations on the treatment of early rheumatoid arthritis
5. New research suggests early diet may play key role in protecting against childhood leukaemia
6. White House to honor UNC School of Medicine scientist for early career achievement
7. Men from early middle ages were nearly as tall as modern people
8. New imaging technology at Joslin shown to detect early signs of type 1 diabetes
9. Millennia still mean early days for newly identified sex chromosome
10. Preschool bolsters early childhood immunity, reduces risk of young adult Hodgkins lymphoma
11. OHSU researchers discover possible method for early detection, prevention of premature birth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/9/2019)... ... April 09, 2019 , ... The McLeod Center for ... following a rigorous and voluntary audit conducted by an independent, third-party panel of ... Novalis Certified Centers in the United States, McLeod is the only such cancer center ...
(Date:4/4/2019)... GALWAY, Ireland (PRWEB) , ... April 02, 2019 ... ... discovery, development and commercialization of first-in-class stromal cell immunotherapies, announced it will move ... to become the anchor tenant at the University’s newly created biotechnology park in ...
(Date:4/4/2019)... , ... April 03, 2019 , ... ... stem cell therapies performed at its nationwide Centers of Excellence. R3 wants patients ... cell therapy provider. , To protect patients from Centers that use inferior regenerative ...
Breaking Biology News(10 mins):
(Date:4/10/2019)... ... April 10, 2019 , ... ... locked into multiple agreements to help companies advance their innovations to clinical ... ranging from synthetic biology companies that are gene editing therapeutic cells for ...
(Date:4/9/2019)... ... 09, 2019 , ... USDM Life Sciences , the ... organizations to accelerate innovation and maximize productivity, announces that nearly 100 companies have ... , USDM’s Cloud Assurance is a managed subscription service delivering end-to-end ...
(Date:4/9/2019)... ... April 09, 2019 , ... The American Society of Gene & ... leadership team, including a new addition to the presidential line of succession, at the ... join the Society's leadership team for a three-year term (2019-2021). , All five incoming ...
(Date:4/8/2019)... SAN FRANCISCO (PRWEB) , ... April 08, 2019 , ... ... to accredited investors a $15 million preferred equity investment in the privately held pharmaceutical ... dysfunction. Its leading drug, Lorexys, is targeted at female hypoactive sexual dysfunction disorder and ...
Breaking Biology Technology:
Cached News: