HOME >> BIOLOGY >> NEWS
Knockout Mouse Reveals Genetic Mechanism In Defective Mammalian Ear Development

BAR HARBOR -- A control mechanism for the proper development of inner ear "hair cells" -- sensory cells that are critical for normal hearing in mammals such as mice and humans -- has been found to involve two interacting genes in a molecular signaling pathway known to direct cell fate in many different organisms, including fish and insects.

This control mechanism, which involves the genes Jagged2 and Notch1, was identified in a collaborative effort by research teams headed by Dr. Matthew Kelley at the Georgetown University School of Medicine and Dr. Thomas Gridley at The Jackson Laboratory. The results are reported in "The Notch Signaling Pathway Mediates Hair Cell Development in the Mammalian Cochlea" in the March 1999 issue of Nature Genetics.

Dr. Gridley has conducted extensive research on the Notch signaling pathway and led the team that reported last year on developmental defects in Jagged2 knockout mice from The Jackson Laboratory. He describes the pathway -- first studied in the fruit fly -- as a molecular mechanism that mediates communication between cells as they differentiate during embryonic development. In humans, Notch pathway mutations have been implicated in cancer and in several inherited disease syndromes.

"This work clearly establishes that identical mechanisms to control the development of sensory cells operate in both mammals and in lower organisms, such as the fruit fly," said Dr. Gridley. "Such evolutionary conservation of mechanism emphasizes the importance of the Notch signaling pathway for normal development. This pathway is a key regulator controlling the proper development of many different cell types."

The mammalian inner ear, or cochlea, is lined with an intricate "mosaic" of alternating hair cells and non-sensory supporting cells. Normal hearing results when sound waves cause the tiny hairs to oscillate, and the movement is transmitted as electrical impulses through the hair cells to t
'"/>

Contact: Luther Young
loy@jax.org
207-288-6052
Jackson Laboratory
28-Feb-1999


Page: 1 2

Related biology news :

1. Knockout research eases study of plant gene functions
2. Knockout of cav-1 protein causes loss of a cellular organelle
3. Knockout mouse may lead to major understanding of human kidney disorder
4. Gene Knockout Prolongs Ovarian Lifespan In Mice
5. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
6. Defects In Embryonic Development In Lunatic Fringe Knockout Mice
7. Half-million dollar landmark achieved for the Methuselah Mouse Prize
8. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
9. Mouse brain stem cells capable of converting into blood vessel cells
10. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
11. Mouse embryonic germ cells and male gametes created in the lab

Post Your Comments:
(Date:11/18/2014)... WASHINGTON , Nov. 18, 2014  The ... Security Industry Association today jointly announce the formation ... and release of its Identity and Biometric ... (Framework). The Framework received official support from BORDERPOL, ... governments to improve and provide expertise regarding border ...
(Date:11/12/2014)... 12, 2014 Crossmatch™, a leading provider of ... ® fingerprint readers have been deployed throughout Montparnasse ... Central Mexico . The bakery chain implemented the ... issues caused by employees clocking in for each other. ... readers, Montparnasse relied on paper timecards and a mechanical ...
(Date:11/7/2014)... , November 6, 2014 Leading Biometric ... better mobile security revolutionizing online transactions.  Companies in focus today ... Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... eBay Inc. (NASDAQ: EBAY ) and MasterCard Inc. ... and NXTDW), a biometric authentication company focused on the ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
(Date:11/21/2014)... 20, 2014 Polaris Group announced today ... its Phase 1 trial of ADI-PEG 20 in ... of malignant pleural mesothelioma (MPM) and non-squamous non-small ... trials on ADI-PEG 20, both as monotherapy and ... of several other indications, including breast cancer, melanomas, ...
(Date:11/21/2014)... , Nov. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or ... month periods ended September 30, 2014.  Biorem,s complete 2014 third quarter ... ). Financial Summary:Three-months ended September 30, , ... share data) , 2014 , 2013 ... , 5,281 , 6,715 , ...
(Date:11/18/2014)... 2014 Cirrascale Corporation ®, ... and rackmount computing infrastructure, today announced it will ... throughout its GPU-enabled blade server and high-performance workstation ... latest proprietary 80-lane Gen3 PCIe switch-enabled risers, the ... K80 dual-GPU accelerator cards in a single blade, ...
(Date:11/18/2014)... New Brunswick, NJ (PRWEB) November 18, 2014 ... of Data Quality and Transparency Reporting solutions, announced ... has gone live using its Consummate Providerâ„¢ solution ... Consummate Providerâ„¢ is a Global, SaaS based, Data ... Science organizations and their third party Providers improve ...
Breaking Biology Technology:Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2
Cached News: