HOME >> BIOLOGY >> NEWS
Knockout Mouse Reveals Genetic Mechanism In Defective Mammalian Ear Development

BAR HARBOR -- A control mechanism for the proper development of inner ear "hair cells" -- sensory cells that are critical for normal hearing in mammals such as mice and humans -- has been found to involve two interacting genes in a molecular signaling pathway known to direct cell fate in many different organisms, including fish and insects.

This control mechanism, which involves the genes Jagged2 and Notch1, was identified in a collaborative effort by research teams headed by Dr. Matthew Kelley at the Georgetown University School of Medicine and Dr. Thomas Gridley at The Jackson Laboratory. The results are reported in "The Notch Signaling Pathway Mediates Hair Cell Development in the Mammalian Cochlea" in the March 1999 issue of Nature Genetics.

Dr. Gridley has conducted extensive research on the Notch signaling pathway and led the team that reported last year on developmental defects in Jagged2 knockout mice from The Jackson Laboratory. He describes the pathway -- first studied in the fruit fly -- as a molecular mechanism that mediates communication between cells as they differentiate during embryonic development. In humans, Notch pathway mutations have been implicated in cancer and in several inherited disease syndromes.

"This work clearly establishes that identical mechanisms to control the development of sensory cells operate in both mammals and in lower organisms, such as the fruit fly," said Dr. Gridley. "Such evolutionary conservation of mechanism emphasizes the importance of the Notch signaling pathway for normal development. This pathway is a key regulator controlling the proper development of many different cell types."

The mammalian inner ear, or cochlea, is lined with an intricate "mosaic" of alternating hair cells and non-sensory supporting cells. Normal hearing results when sound waves cause the tiny hairs to oscillate, and the movement is transmitted as electrical impulses through the hair cells to t
'"/>

Contact: Luther Young
loy@jax.org
207-288-6052
Jackson Laboratory
28-Feb-1999


Page: 1 2

Related biology news :

1. Knockout research eases study of plant gene functions
2. Knockout of cav-1 protein causes loss of a cellular organelle
3. Knockout mouse may lead to major understanding of human kidney disorder
4. Gene Knockout Prolongs Ovarian Lifespan In Mice
5. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
6. Defects In Embryonic Development In Lunatic Fringe Knockout Mice
7. Half-million dollar landmark achieved for the Methuselah Mouse Prize
8. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
9. Mouse brain stem cells capable of converting into blood vessel cells
10. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
11. Mouse embryonic germ cells and male gametes created in the lab

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... India , December 7, 2016 According to a ... Machine Learning), Software Tool (Facial Expression, Voice Recognition), Service, Application Area, End User, ... is estimated to grow from USD 6.72 Billion in 2016 to USD 36.07 ... Continue Reading ... ...
(Date:12/7/2016)...   Veridium , a leader in biometrics-based ... CEO James Stickland . Stickland, a seasoned ... has served in senior executive roles for HSBC, ... expanding a pipeline of venture capital and accelerating ... served as managing director of U.K.-based fintech firm ...
(Date:12/6/2016)... , Dec. 6, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... announced today a five (5) year funding commitment ... to expand the rehabilitation and reentry support to ... History Established in 2004, the Prison Entrepreneurship Program ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... Linda, Ca (PRWEB) , ... ... ... for low-cost, disposable devices with short response times capable of performing routine ... food fields, disposable screen-printed electrodes provide fast, sensitive detection and quantification of ...
(Date:1/12/2017)... ... January 12, 2017 , ... After her ... Rosendahl’s doctors gave her only a few months to live. Now a paper ... has stabilized Rosendahl’s disease and increased both the quantity and quality of her ...
(Date:1/12/2017)... 2017   Protein Sciences Corporation , a ... Flublok Influenza Vaccine ®, announced today that its ... safety results and induced strong neutralizing antibodies against ... is expected to advance into human clinical trials ... Institute of Technology in Immunobiologicals of the Oswaldo ...
(Date:1/12/2017)... The report "Direct-Fed Microbials Market by Type (Lactic Acid Bacteria and Bacillus), Livestock (Pork/Swine, ... Forecast to 2022", published by MarketsandMarkets, the global market is estimated to be ... Million by 2022, at a CAGR of 6.96% from 2016. ... ... Logo ...
Breaking Biology Technology:
Cached News: