HOME >> BIOLOGY >> NEWS
Knockout Mouse Reveals Genetic Mechanism In Defective Mammalian Ear Development

BAR HARBOR -- A control mechanism for the proper development of inner ear "hair cells" -- sensory cells that are critical for normal hearing in mammals such as mice and humans -- has been found to involve two interacting genes in a molecular signaling pathway known to direct cell fate in many different organisms, including fish and insects.

This control mechanism, which involves the genes Jagged2 and Notch1, was identified in a collaborative effort by research teams headed by Dr. Matthew Kelley at the Georgetown University School of Medicine and Dr. Thomas Gridley at The Jackson Laboratory. The results are reported in "The Notch Signaling Pathway Mediates Hair Cell Development in the Mammalian Cochlea" in the March 1999 issue of Nature Genetics.

Dr. Gridley has conducted extensive research on the Notch signaling pathway and led the team that reported last year on developmental defects in Jagged2 knockout mice from The Jackson Laboratory. He describes the pathway -- first studied in the fruit fly -- as a molecular mechanism that mediates communication between cells as they differentiate during embryonic development. In humans, Notch pathway mutations have been implicated in cancer and in several inherited disease syndromes.

"This work clearly establishes that identical mechanisms to control the development of sensory cells operate in both mammals and in lower organisms, such as the fruit fly," said Dr. Gridley. "Such evolutionary conservation of mechanism emphasizes the importance of the Notch signaling pathway for normal development. This pathway is a key regulator controlling the proper development of many different cell types."

The mammalian inner ear, or cochlea, is lined with an intricate "mosaic" of alternating hair cells and non-sensory supporting cells. Normal hearing results when sound waves cause the tiny hairs to oscillate, and the movement is transmitted as electrical impulses through the hair cells to t
'"/>

Contact: Luther Young
loy@jax.org
207-288-6052
Jackson Laboratory
28-Feb-1999


Page: 1 2

Related biology news :

1. Knockout research eases study of plant gene functions
2. Knockout of cav-1 protein causes loss of a cellular organelle
3. Knockout mouse may lead to major understanding of human kidney disorder
4. Gene Knockout Prolongs Ovarian Lifespan In Mice
5. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
6. Defects In Embryonic Development In Lunatic Fringe Knockout Mice
7. Half-million dollar landmark achieved for the Methuselah Mouse Prize
8. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
9. Mouse brain stem cells capable of converting into blood vessel cells
10. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
11. Mouse embryonic germ cells and male gametes created in the lab

Post Your Comments:
(Date:4/15/2014)... Biologists at UC San Diego have succeeded in ... hormone responsible for growth and resistance to drought. ... studies to determine how the hormone helps plants ... by the continuing increase in the atmosphere,s carbon ... achievement appears in the April 15 issue of ...
(Date:4/15/2014)... Looking at the question of how social behavior has ... universities in Mainz and Basel have gained new insights ... simply compete for food. Rather the siblings share what ... absent," explained Dr. Jol Meunier of the Evolutionary Biology ... University of Mainz (JGU). The team of biologists from ...
(Date:4/15/2014)... (April 15, 2014) The American Association of Anatomists ... All awards will be presented during the Closing ... Hotel on Tuesday, April 29th at 7:30 p.m. during ... , The 2014 award winners are: , ... PhD, of the Icahn School of Medicine at Mount ...
Breaking Biology News(10 mins):Biologists develop nanosensors to visualize movements and distribution of plant hormone 2Sibling cooperation in earwig families gives clues to early evolution of social behavior 2American Association of Anatomists 2014 award winners 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
Cached News: