HOME >> BIOLOGY >> NEWS
Knockout of cav-1 protein causes loss of a cellular organelle

Scientists from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, the Franz Volhard Clinic of the Charit, Humboldt-University Berlin and Max Delbrck Center for Molecular Medicine, Berlin-Buch, were able to cause loss of caveolae and by studying mice lacking this organelle, describe the function of caveolae in mammals. The latest issue of the scientific journal "Science" (published online August 9, 2001; 10.1126/science. 1062688 (Science Express Reports)) reports the current status of the research "Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice".

An exciting new discovery and possibly providing the first example of an organelle knockout is the absence of caveolae after the protein caveolin-1 (cav-1) is genetically prevented from being expressed in transgenic mice. The scientists have characterised the phenotype of transgenic mice that lack caveolin-1 and have found that the mice lack caveolae, the small cave-like invaginations of the plasma membrane of a variety of eukaryotic cells. More than 50 years after the discovery of caveolae their function remains a matter of speculation and controversy. The study provides clues as to the function of these organelles and also provides the first example of the effect of removing a cellular organelle.

Caveolae have been associated with various cellular processes such as transcytosis of solutes through endothelial cells, cholesterol transport, signal transduction and tumor suppression. They have a characteristic flask-shape with a diameter of 50-100 nm and are present on many cell types, including endothelial, smooth muscle cells and fat cells. They represent a form of lipid rafts within the plasma membrane, enriched in cholesterol and glycolipids. Cav-1, a small protein of only 21-22 kDa, is to date the best biochemical marker for caveolae. It is assumed to be the major structural component of the caveolar coat that is seen in electron mi
'"/>

Contact: Claudia Lorenz
claudia.lorenz@mpi-cbg.de
49-351-210-2030
Max-Planck-Gesellschaft
10-Aug-2001


Page: 1 2

Related biology news :

1. Knockout research eases study of plant gene functions
2. Knockout mouse may lead to major understanding of human kidney disorder
3. Knockout Mouse Reveals Genetic Mechanism In Defective Mammalian Ear Development
4. Gene Knockout Prolongs Ovarian Lifespan In Mice
5. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
6. Defects In Embryonic Development In Lunatic Fringe Knockout Mice
7. New molecular link key to cellular proteins involved in cancer progression, other diseases
8. Researchers identify protein promoting vascular tumor growth
9. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
10. Experimental drug shown to block mutant protein causing blood disease
11. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Knockout cav protein causes loss cellular organelle

(Date:7/30/2014)... 2014 ResearchMoz presents this ... Systems Market 2014-2024   Business Strategies, Industry Trends, and ... Market 2014-2024" offers the reader detailed analysis of ... ten years, alongside potential market opportunities to enter ... To view the table of contents for ...
(Date:7/30/2014)... better decisions about what they eat, the Food and ... to the Nutrition Facts label found on nearly every ... Chemical & Engineering News (C&EN), the weekly news ... updates and the fight that has ensued. , ... that while the Nutrition Facts label has remained largely ...
(Date:7/30/2014)... Wallerian degeneration is a subject of major interest ... differentially regulated during the distinct stages of Wallerian ... differentiation and dedifferentiation. Although gene expression responses in ... peripheral nerve injury are known, differences in gene ... unclear. Dr. Dengbing Yao and co-workers from Nantong ...
Breaking Biology News(10 mins):Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 4Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 5Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 6Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 7Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 8Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 9Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 10
(Date:7/30/2014)... Diego, CA (PRWEB) July 30, 2014 ... contract from the U.S. Environmental Protection Agency (EPA). ... expertise in developmental toxicity models, including tests designed ... neuron formation and the formation of connections between ... Inhibition of neurodifferentiation and synapse formation by environmental ...
(Date:7/30/2014)... July 30, 2014 Immunology ... leading Immunologists, Principle Investigators, scientists in the field, ... Malemud, Professor at Case Western Reserve University School ... keynote address on “The effects of recombinant ... of matrix metalloproteinase-9”. Arya Biragyn, a Senior investigator ...
(Date:7/29/2014)... July 30, 2014 SoundConnect ... collaboration company, is proud to announce the strategic ... positions in their Boston, Charleston and Atlanta offices. ... the increased demand for hosted solutions, collaboration and ... and reduce cost. , SoundConnect was founded in ...
(Date:7/29/2014)... have hurdled a number of significant technological challenges ... observing technology originally created for the James Webb ... Investigator Harvey Moseley, a scientist at NASA,s Goddard ... that electrostatically actuated microshutter arrays that is, ... are as functional as the current technology,s magnetically ...
Breaking Biology Technology:U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3SoundConnect Organization and Culture is Evolving 2Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4
Cached News: