HOME >> BIOLOGY >> NEWS
Knockout of cav-1 protein causes loss of a cellular organelle

Scientists from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, the Franz Volhard Clinic of the Charit, Humboldt-University Berlin and Max Delbrck Center for Molecular Medicine, Berlin-Buch, were able to cause loss of caveolae and by studying mice lacking this organelle, describe the function of caveolae in mammals. The latest issue of the scientific journal "Science" (published online August 9, 2001; 10.1126/science. 1062688 (Science Express Reports)) reports the current status of the research "Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice".

An exciting new discovery and possibly providing the first example of an organelle knockout is the absence of caveolae after the protein caveolin-1 (cav-1) is genetically prevented from being expressed in transgenic mice. The scientists have characterised the phenotype of transgenic mice that lack caveolin-1 and have found that the mice lack caveolae, the small cave-like invaginations of the plasma membrane of a variety of eukaryotic cells. More than 50 years after the discovery of caveolae their function remains a matter of speculation and controversy. The study provides clues as to the function of these organelles and also provides the first example of the effect of removing a cellular organelle.

Caveolae have been associated with various cellular processes such as transcytosis of solutes through endothelial cells, cholesterol transport, signal transduction and tumor suppression. They have a characteristic flask-shape with a diameter of 50-100 nm and are present on many cell types, including endothelial, smooth muscle cells and fat cells. They represent a form of lipid rafts within the plasma membrane, enriched in cholesterol and glycolipids. Cav-1, a small protein of only 21-22 kDa, is to date the best biochemical marker for caveolae. It is assumed to be the major structural component of the caveolar coat that is seen in electron mi
'"/>

Contact: Claudia Lorenz
claudia.lorenz@mpi-cbg.de
49-351-210-2030
Max-Planck-Gesellschaft
10-Aug-2001


Page: 1 2

Related biology news :

1. Knockout research eases study of plant gene functions
2. Knockout mouse may lead to major understanding of human kidney disorder
3. Knockout Mouse Reveals Genetic Mechanism In Defective Mammalian Ear Development
4. Gene Knockout Prolongs Ovarian Lifespan In Mice
5. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
6. Defects In Embryonic Development In Lunatic Fringe Knockout Mice
7. New molecular link key to cellular proteins involved in cancer progression, other diseases
8. Researchers identify protein promoting vascular tumor growth
9. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
10. Experimental drug shown to block mutant protein causing blood disease
11. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2019)... (PRWEB) , ... January 09, 2019 , ... Dr. Beanlands ... Heart Institute in Ottawa, Ontario, Canada. He is also Director of its National ... of Medicine, in the Department of Radiology, and in the Department of Cellular and ...
(Date:1/8/2019)... ... January 07, 2019 , ... Join industry experts Julie Peacock, Client Services at ... on Thursday, January 17, 2019 at 1pm EST. , This webinar will ... clinical trial process. Featured speakers will also present a case study of a leading ...
(Date:1/7/2019)... (PRWEB) , ... January 07, 2019 , ... ... (RWD) and Artificial Intelligence solutions for precision health in oncology and other key ... J.P Morgan’s exclusive meeting of investors, entrepreneurs and executives spanning the entire healthcare ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... FRANKLIN, Wis. (PRWEB) , ... December 13, 2018 ... ... HACCP scope which now includes food (human) ingredient. This has been part of ... Having a Food Safety Plan and certification creates custom fermentation opportunities for MDG ...
(Date:12/5/2018)... ... December 05, 2018 , ... Leading authority on how to ... guide with his “The Referral Playbook: How to Increase Sales with Proven Networking ... proceeds will go to the Alzheimer’s Foundation of America (AFA). , Itzkowich is ...
(Date:12/5/2018)... ... December 05, 2018 , ... STRmix™ – sophisticated forensic software capable of resolving ... used to convict a Wyoming man of third-degree sexual assault, a felony punishable by ... test for DNA on the couch cushions on which the sexual assault was alleged ...
(Date:11/29/2018)... , ... November 29, 2018 , ... RAGS, today announced ... by Kickstart Seed Fund, with participation from existing investor and board member Jeremy Andrus, ... Smith of Cotopaxi. The additional funding will enable the company to accelerate its growth ...
Breaking Biology Technology:
Cached News: