HOME >> BIOLOGY >> NEWS
Knockout of cav-1 protein causes loss of a cellular organelle

Scientists from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, the Franz Volhard Clinic of the Charit, Humboldt-University Berlin and Max Delbrck Center for Molecular Medicine, Berlin-Buch, were able to cause loss of caveolae and by studying mice lacking this organelle, describe the function of caveolae in mammals. The latest issue of the scientific journal "Science" (published online August 9, 2001; 10.1126/science. 1062688 (Science Express Reports)) reports the current status of the research "Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice".

An exciting new discovery and possibly providing the first example of an organelle knockout is the absence of caveolae after the protein caveolin-1 (cav-1) is genetically prevented from being expressed in transgenic mice. The scientists have characterised the phenotype of transgenic mice that lack caveolin-1 and have found that the mice lack caveolae, the small cave-like invaginations of the plasma membrane of a variety of eukaryotic cells. More than 50 years after the discovery of caveolae their function remains a matter of speculation and controversy. The study provides clues as to the function of these organelles and also provides the first example of the effect of removing a cellular organelle.

Caveolae have been associated with various cellular processes such as transcytosis of solutes through endothelial cells, cholesterol transport, signal transduction and tumor suppression. They have a characteristic flask-shape with a diameter of 50-100 nm and are present on many cell types, including endothelial, smooth muscle cells and fat cells. They represent a form of lipid rafts within the plasma membrane, enriched in cholesterol and glycolipids. Cav-1, a small protein of only 21-22 kDa, is to date the best biochemical marker for caveolae. It is assumed to be the major structural component of the caveolar coat that is seen in electron mi
'"/>

Contact: Claudia Lorenz
claudia.lorenz@mpi-cbg.de
49-351-210-2030
Max-Planck-Gesellschaft
10-Aug-2001


Page: 1 2

Related biology news :

1. Knockout research eases study of plant gene functions
2. Knockout mouse may lead to major understanding of human kidney disorder
3. Knockout Mouse Reveals Genetic Mechanism In Defective Mammalian Ear Development
4. Gene Knockout Prolongs Ovarian Lifespan In Mice
5. Vertex Pharmaceuticals/Yale Research Team Uses Gene Knockout Mice To Establish Role Of Caspase-9 In Neuronal Cell Death Pathway
6. Defects In Embryonic Development In Lunatic Fringe Knockout Mice
7. New molecular link key to cellular proteins involved in cancer progression, other diseases
8. Researchers identify protein promoting vascular tumor growth
9. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
10. Experimental drug shown to block mutant protein causing blood disease
11. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... 2016 First quarter 2016:   ... with the first quarter of 2015 The gross margin ... (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... unchanged, SEK 7,000-8,500 M. The operating margin for 2016 ...
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge (BDC), ... new ways to harness living systems and biotechnology, announced ... (MoMA) in New York City . ... participating students, showcased projects at MoMA,s Celeste Bartos Theater ... Antonelli , MoMA,s senior curator of architecture and design, ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published ... how a patient who developed lymphedema after being treated for breast cancer benefitted from ... the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... the trading session at 4,833.32, down 0.22%; the Dow Jones ... the S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ... BIND Therapeutics Inc. (NASDAQ: BIND ). Learn more ...
(Date:6/23/2016)... 2016  Amgen (NASDAQ: AMGN ) today ... life sciences incubator to accelerate the development of ... space at QB3@953 was created to help high-potential life ... many early stage organizations - access to laboratory infrastructure. ... launched two "Amgen Golden Ticket" awards, providing each winner ...
Breaking Biology Technology:
Cached News: