HOME >> BIOLOGY >> NEWS
'Knockout' research eases study of plant gene functions

A North Carolina State University geneticist has helped create a powerful new tool to assist plant researchers in their studies of individual gene functions in the so-called lab rat of plant research Arabidopsis thaliana, or mustard weed.

That's important, says Dr. Jose Alonso, assistant professor of genetics at NC State, because knowing the functions of specific genes in Arabidopsis gives researchers the ability to apply that knowledge to gene studies in other plants. Genetically, Arabidopsis has a great deal in common with other plants, Alonso says.

Alonso's work led to the creation of lines of Arabidopsis plants that have certain genes knocked out, or turned off. The seeds of these plants are held at a seed stock center at the Arabidopsis Biological Resource Center at The Ohio State University and are publicly available to researchers all over the world, making it much simpler for a scientist to study specific gene function in his or her own lab.

The research is presented in a paper published in the Aug. 1 issue of Science. Alonso is the paper's lead author.

To arrive at the findings, Alonso and his colleagues used a method called insertional mutagenesis, in which foreign DNA was randomly inserted into the Arabidopsis genome. When the foreign DNA hit a gene, that specific gene was turned off.

Of the predicted 29,454 genes in Arabidopsis the genome of the plant has already been sequenced, so scientists were able to accurately map the locations of the inserted DNA 21,799, or 74 percent of the genes, were knocked out using insertional mutagenesis, the paper states.

Now, libraries of Arabidopsis seeds with specific single genes knocked out have been compiled and are available for public consumption. Researchers studying a specific gene can quickly and easily search for an Arabidopsis plant that has a particular gene turned off, and order it from the Arabidopsis Resource Center.

Alonso started the project and
'"/>

Contact: Dr. Jose Alonso
jmalonso@unity.ncsu.edu
919-515-2292
North Carolina State University
31-Jul-2003


Page: 1 2

Related biology news :

1. Knockout mouse may lead to major understanding of human kidney disorder
2. Leader in cancer treatment and prevention research honored
3. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
4. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
5. Belgian researchers explore revolutionary approach to angiogenesis
6. Award winning researchers reveal potential new role for Glivec
7. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
8. 16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
9. Gene chips research in cotton could lead to superior variety
10. Groundbreaking research could ignite new solutions to heat transfer in nano-devices
11. New hydrothermal vents discovered as South Pacific Odyssey research begins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... WORCESTER, Mass. (PRWEB) , ... May 21, 2019 ... ... released into the environment, how will we know? How can we tell it ... the challenge being taken on by a multi-institution research team, including Eric ...
(Date:5/21/2019)... ... 21, 2019 , ... Zer0 to 5ive, an award-winning strategic ... celebrate launched a new startup package, 0to5 Launch, to provide seed-stage and early-stage ... to attract talent and investors. , “We launched our Zer0 to 5ive Roadmap™ ...
(Date:5/21/2019)... , ... May 20, 2019 , ... ... health care field, today announced a 96.15% pass rate for first-time test takers ... This surpasses the national average of 76.43% by nearly 20 points. , ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ANTONIO (PRWEB) , ... April 16, 2019 , ... ... human identification systems, applications, and technology, today announced that Bank South Pacific (BSP), ... a competitive RFP process. The bank awarded Fulcrum a contract to deliver a ...
(Date:4/9/2019)... SANTA BARBARA, Calif. (PRWEB) , ... April 09, ... ... global professional services firm focused on increasing the capacity of life sciences organizations ... to its Cloud Assurance platform in the past 12 months. , ...
(Date:4/8/2019)... ... April 09, 2019 , ... ... innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious Biologics ... repertoires is part of CZ Biohub’s efforts to establish new approaches to inform ...
(Date:3/27/2019)... (PRWEB) , ... March 27, 2019 , ... In honor ... raise awareness on the importance of healthy meals and good nutrition. This month, ... the Food Bank’s volunteer chef. , The first segment addressed the nutritional ...
Breaking Biology Technology:
Cached News: