HOME >> BIOLOGY >> NEWS
LDL receptor reduces LDL production, removes cholesterol from blood

poB is degraded inside the cells before they secrete very low-density lipoprotein into the blood.

Attie led the research team, which included Jaap Twisk, Donald Gillian-Daniel, Angie Tebon, Lin Wang, and Hugh Barrett. Barrett is with the University of Western Australia in Perth; the others were with the UW-Madison at the time the research was done. Twisk is now with the University of Leiden in the Netherlands, and Wang is at the University of California-San Diego in La Jolla, Calif.

The scientists studied liver cells from mice with functional LDL receptors and mice with mutant, nonfunctional receptors. Mice with the mutation showed symptoms analogous to those of people with FH. Their average blood cholesterol level was more than three times that of mice with functioning receptors.

The researchers examined how the presence or absence of LDL receptors affected the secretion of apoB from mouse liver cells. They studied apoB secretion from cells with receptors, from cells with the mutation, and from mutant cells they altered by introducing unusually large numbers of functional receptors.

"We found that although all three types of cells synthesized the same amount of apoB, they degraded different amounts before secreting it," Attie says.

The study found that liver cells with functional receptors degraded 55 percent of the apoB they made before releasing it. Liver cells with FH-like mutant receptors degraded only 20 percent of the apoB they made. However, when large numbers of functional receptors were added to those same mutant cells, they degraded 90 percent of the apoB they synthesized before secreting it.

The results also explain why statin medications -- which include the brands Lipitor, Zocor, Pravachol, Lescol, Mevacor and Baycol -- are effective in lowering serum LDL levels. As a class of pharmaceuticals, statins inhibit cholesterol production. Liver cells respond to this decrease in cholesterol by producing more LDL receptors on their surf
'"/>

Contact: Alan Attie
attie@biochem.wisc.edu
608-262-1372
University of Wisconsin-Madison
4-Apr-2000


Page: 1 2 3

Related biology news :

1. Ovarian cancer sheds tumor suppression with loss of estrogen receptor
2. Alterations in vitamin D receptor gene increase prostate, breast cancer risk
3. Two-pronged attack targeting EGF receptor hinders cancer cell growth
4. Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
5. Dioxin-receptor network identified
6. Inhibition of insulin-like growth factor receptor-1 as promising anticancer therapeutic
7. Scientists at Scripps Research Institute describe structure of receptor on surface of 1918 flu virus
8. Activation of receptor ups development of precancerous intestinal polyps
9. Researchers find an association between alcohol dependence and the GABAA receptor gene GABRG3
10. The dopamine receptor D1 gene and ADHD: A piece of the genetic puzzle?
11. Estrogen receptor-a disruption and vasodilation in coronary arteries

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: