Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy

Rockefeller University researchers have for the first time demonstrated a halting of early Type 1 diabetes in mice by restoring a critical class of T cells to their normal balance.

The findings, reported in the June 7 issue of the Journal of Experimental Medicine, prove an important biological principle that could lead to prevention of Type 1 diabetes in humans: autoimmunity can be reversed if the immune system's mechanisms for tolerance -- recognition and acceptance of the body's own cells -- can be repaired.

Using immune system cells called dendritic cells to stimulate increased numbers of suppressor T cells, which turn off the body's immune response, the research team rescued mice from the destruction of their pancreatic islet cells that causes Type 1 diabetes. The research was led by Kristin Tarbell, Ph.D., a postdoctoral associate in Rockefeller's Laboratory of Cellular Physiology and Immunology, headed by professor and senior physician Ralph Steinman, M.D.

"You have to stop the immune system from attacking those pancreatic islet cells," says Tarbell. Otherwise, even with the possibility of islet cell transplants, the same process that destroyed the first set will destroy the second, Tarbell explains.

"Instead of silencing the attackers directly, we learned how to generate another type of cell, called a regulatory or suppressor cell, which essentially turns off the attackers. Basically, it's a numbers game, and the problem in the onset of this disease is that there are not enough of the regulatory cells that suppress the immune response against the body's insuling-producing pancreatic islet cells," says Tarbell. Putting the right number (in the case of mice, 5000 to 50,000) of regulatory T cells where they are needed arrests the onset of Type 1 diabetes in the animals.

This research used a special source of T cells from mice genetically altered to have a majority of cells directed to the islets. Now Tarbell will exten

Contact: Lynn Love
Rockefeller University

Page: 1 2 3 4

Related biology news :

1. Siberian tiger rescued from poachers snare
2. Joslin Diabetes Center honors brothers living 70-plus years with type 1 diabetes
3. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
4. A probable cause for high blood pressure identified - shows links with diabetes
5. Joslin President awarded medal from international diabetes organization
6. New imaging technology at Joslin shown to detect early signs of type 1 diabetes
7. Protemix corporation announces discovery of way to repair hearts damaged by diabetes
8. Genetic mutation found that is major contributor to type 1 diabetes
9. Joslin researchers identify key molecule in Type 1 diabetes progression
10. Gestational diabetes not found to alter the metabolic processes in obese pregnant women
11. Study links diabetes and colorectal cancer

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: