HOME >> BIOLOGY >> NEWS
Lack of Rb2 gene could be early indicator of prostate cancer, say Temple researchers

The progressive lack of the tumor suppressor gene Rb2/p130 could be an early indicator of prostate cancer in males, according to a study by researchers at Temple University's College of Science and Technology.

The results of the study, "Expression of Cell-Cycle-regulated Proteins pRb2/p130, p107, p27kip1, p53, Mdm-2, and Ki-67 (MIB-1) in Prostatic Gland Adenocarcinoma," appear in the June issue of Clinical Cancer Research (http://clincancerres.aacrjournals.org).

In the study, which was started at Thomas Jefferson University and completed at Temple's Sbarro Institute for Cancer Research and Molecular Medicine, the researchers looked at the pattern of protein expression in a variety of molecular markers in prostate cancer, including Rb2, p107, p27, p53, Mdm-2, and Ki-67.

"The results we obtained with Rb2, which is a tumor suppressor gene, indicate that this gene demonstrates a lower expression in the prostate as it progresses from normal to cancerous," says Antonio Giordano, Ph.D., M.D., head of the Sbarro Institute and one of the study's lead researchers. "The lack of this tumor suppressor gene can, in a certain sense be, an indicator of tumor progression in the prostate gland."

Giordano says the results of the study show that in addition to PSA (prostate specific antigen), a protein whose level in the blood increases in some men who have prostate cancer, there are other factors that could serve as major indicators for individuals susceptible to developing prostate cancer, which is the leading cause of death by cancer of American men.

"For the first time, we have demonstrated that there really is a link between the Rb2/p130 and prostate cancer," says Giordano, a professor of biology at Temple (http://www.temple.edu/news_media/hkg696.html). "It's clear that this study is leading us to an early diagnostic test for
'"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-7476
Temple University
6-Jun-2002


Page: 1 2 3

Related biology news :

1. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
2. Circulation of disaster myths in Haiti could hinder appropriate disposal of bodies
3. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
4. Marijuana use could cause tubal pregnancies
5. Gene chips research in cotton could lead to superior variety
6. Groundbreaking research could ignite new solutions to heat transfer in nano-devices
7. Bullish chemical could repel yellow fever mosquitoes
8. Termites could hold the key to self-sufficient buildings
9. Wastewater could treat itself, power city
10. Sugar-coated sea urchin eggs could have sweet implications for human fertility
11. Identifying tick genes could halt disease, bioterrorism threat

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... focused on quality, regulatory and technical consulting, provides a free webinar ... presented on July 13, 2016 at 12pm CT at no charge. , Incomplete ...
(Date:6/23/2016)... June 22, 2016  Amgen (NASDAQ: AMGN ... QB3@953 life sciences incubator to accelerate the ... shared laboratory space at QB3@953 was created to help ... obstacle for many early stage organizations - access to ... sponsorship, Amgen launched two "Amgen Golden Ticket" awards, providing ...
(Date:6/22/2016)... June 22, 2016 Cell Applications, Inc. ... them to produce up to one billion human ... within one week. These high-quality, consistent stem cells ... cells and spend more time doing meaningful, relevant ... proprietary, high-volume manufacturing process that produces affordable, reliable ...
(Date:6/22/2016)... , June 22, 2016  According to ... next generation sequencing (NGS) market include significant efforts ... smaller sequencers.  More accessible and affordable sequencers, say ... growing demand for consumables including sample prep materials.  ... Market for Sample Preparation for Next Generation Sequencing ...
Breaking Biology Technology:
Cached News: