HOME >> BIOLOGY >> NEWS
Lack of specific brain protein causes marked deficits in learning, memory

DALLAS April 7, 2004 A protein involved in the release of neurotransmitters in the brain is essential to learning and memory in mice, researchers at UT Southwestern Medical Center at Dallas have found.

A study published today in Neuron offers the first evidence that lack of this protein known as RIM1 alpha causes profound deficits in the learning process. The discovery is a major step in understanding the molecular events that underlie learning and memory complex processes that can be impaired in human neuropsychiatric disorders such as Alzheimer's disease, mental retardation and schizophrenia.

"We found that when you delete this molecule, the mice essentially become incredibly stupid," said Dr. Thomas Sdhof, director of both the Center for Basic Neuroscience and the C. Vincent Prothro Center for Research in Basic Neuroscience at UT Southwestern and co-author of the paper.

Researchers hope that further study of the protein's role in learning and memory will lead to potential treatments for some neuropsychiatric disorders.

"This is the first indication that these proteins could be good targets for treatment of specific brain disorders," said Dr. Craig Powell, assistant professor of psychiatry and neurology at UT Southwestern and the study's lead author.

The researchers compared behaviors of normal mice to those of three sets of genetically altered mice each of which was missing a specific protein involved in releasing neurotransmitters. The mice lacking the RIM1 alpha protein, unlike the others, lacked the ability to learn the location of an escape platform in a pool of water despite repeated attempts over several days.

Dr. Eric Nestler, chairman of psychiatry at UT Southwestern and senior author of the study, said another notable finding was that, while the other two sets of genetically altered mice displayed some of the same cellular abnormalities as the RIM1 alpha mice, these other m
'"/>

Contact: Rachel Horton
rachel.horton@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
7-Apr-2004


Page: 1 2

Related biology news :

1. Veterans with Gulf War syndrome have damage in specific, primitive portion of nervous system
2. Resveratrol synthase uncovered: Cyclization specificity of type III polyketide synthases
3. Anticancer drug zebularine specifically targets tumor cells
4. PCB breakdown in rivers depends on sediment-specific bacteria, find Carnegie Mellon U. scientists
5. X marks the spot: Vector insertion is viral specific
6. Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
7. Sex-specific differences in gene expression related to drug metabolism and hypertension
8. New papillomavirus target could lead to specific antiviral drugs for precancerous cervical lesions
9. HIV exhausts the immune system through chronic non-specific activation
10. Tumor cell-specific therapy shows preclinical promise
11. Researchers find mechanism bacteria use to target specific chemical contaminants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
(Date:7/2/2020)... (PRWEB) , ... July 01, 2020 , ... ... presented its phase 1a findings of Neihulizumab, a biologic for the treatment of ... June 2020. Led by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, ... glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of its ... are charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... WILMINGTON, Del. (PRWEB) , ... August 29, 2020 ... ... of a new Animal Nutrition manufacturing capability in Wuxi, China. The new plant ... DuPont’s global quality standards and advanced technology. , “This facility will improve ...
(Date:8/15/2020)... ... August 13, 2020 , ... ... 5000 list, the most prestigious ranking of the nation’s fastest-growing private companies. The ... economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, Under Armour, Microsoft, Patagonia, ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... engineering firm, is making available for free its new white paper – ... transport simulation testing into today’s biologics licensing application (BLA). In response, Modality ...
(Date:8/7/2020)... WOODLANDS, Texas (PRWEB) , ... August 06, 2020 ... ... therapy and DNA vaccine industries, announces it has closed on the purchase of ... Technology Park in Conroe, TX and includes over 21 acres in the initial ...
Breaking Biology Technology:
Cached News: