HOME >> BIOLOGY >> NEWS
Lactating mammary glands sense calcium

During mammalian reproduction, including that of humans, large amounts of calcium are transferred from mother to offspring through breast milk. Subsequently, adaptive mechanisms are required to maintain a healthy balance of calcium in the mother's body. These involve the breakdown of calcium stores in bone and increased dietary calcium intake in order to maintain a steady supply of calcium to the breast for purposes of milk production. The factors involved in the regulation of calcium stores are largely unknown.

The calcium-sensing receptor (CaR) is known to regulate how our cells respond to fluctuations in extracellular calcium levels. A report from John Wysolmerski and colleagues from Yale University in the February 16 issue of the Journal of Clinical Investigation reveals that in mice, at the transition from pregnancy to lactation, expression of CaR on mammary epithelial cells is upregulated. Dietary restriction of calcium upregulated parathyroid hormone-related protein production during lactation, decreased the calcium content of milk, increased milk osmolality and protein concentration, and decreased overall milk production. Most of these effects were prevented by the infusion of calcimimetic compounds, implicating CaR as the key mediator of these processes. This indicates that the lactating mammary gland can sense calcium increases and losses and adjusts its secretion of calcium accordingly. This helps match milk production with the availability of calcium in the mother's body.


'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
16-Feb-2004


Page: 1

Related biology news :

1. Fortified Drink For Pregnant, Lactating Women
2. Diabodies act as guided missiles targeted to mammary tumor growth
3. Researchers grow breast cancer tissue from transplanted mammary stem cells
4. Three genetic steps convert normal mammary cells into breast cancer cells
5. Cell death during mammary involution
6. NIH panel outlines strategies for managing tumors of the adrenal glands
7. Phase II trials of second-generation antisense cancer drug planned following successful early study
8. Researchers discover how worms noses sense oxygen
9. Chemical reaction in birds provides sense of direction during migratory flights
10. Making sense of the brains mind-boggling complexity
11. Progress in probing the mosquitos sense of smell

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... The research team of The Hong Kong Polytechnic University (PolyU) ... ground breaking 3D fingerprint minutiae recovery and matching technology, pushing contactless ... use in identification, crime investigation, immigration control, security of access and ... ... A research team led by Dr Ajay Kumar ...
(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:5/22/2017)... , ... May 22, 2017 , ... Stratevi, a boutique ... to the East Coast. It has opened an office in downtown Boston at 745 ... finding it increasingly more important to generate evidence on the value they provide, not ...
(Date:5/21/2017)... ... May 20, 2017 , ... ... the lengthy trial and error process by finding the right antidepressant faster. ... strengthen the doctor-patient relationship through a personalized approach to treatment. , ...
(Date:5/18/2017)... (PRWEB) , ... May 18, 2017 , ... ... activities. The Tapas Cooking Challenge is a two-hour team-building package designed for ... menu created by Chef Jodi Abel, which include items, such as Blackened Shrimp ...
(Date:5/18/2017)... Massachusetts (PRWEB) , ... May 17, 2017 , ... ... company specializing in medical device compliance and commercialization, has just released version 9.0 ... of work into this latest version of Cockpit,” says David Cronin, CEO of ...
Breaking Biology Technology:
Cached News: