Landmark obesity study

Trials in mice are promising; human testing on horizon

Denver--August 30, 1999 - Scientists at Denver's Eleanor Roosevelt Institute have discovered a novel method for treating obesity in mice, a finding that could lead to new pharmaceutical treatments for overweight people worldwide. Published in the September issue of the international journal, Nature Medicine, the finding is a dramatic departure from most current obesity research, which concentrates on controlling appetite. This new approach centers on the way in which the body stores and burns fat.

The finding is tied to a gene known as POMC, which is found in both mice and humans. POMC provides signals that are important both during development and also later in life. The team was originally studying the impact of POMC on the development of the brain when they discovered it also played a major role in weight regulation.

"Our research demonstrates that mice lacking POMC-derived signals are obese," said Miles B. Brennan, a scientist at the Institute. "When we treated obese mice with a hormone made by the POMC gene, called MSH, they returned to almost normal weight in a matter of weeks. Further the effect isn't simply a change in appetite, but also in fat storage."

"We continue to do follow-up research in mice and the results are promising so far," said Brennan. "We hope to pair up with a strategic partner that will help move this study in to human clinical trials. If this process works in humans, we hope to get it to the public in the most efficient and timely way possible."

This discovery has implications for many diseases, explained Eleanor Roosevelt Institute President David Patterson. "For example, many people with Down syndrome have difficulty controlling their weight. In addition, medications commonly used to treat epilepsy and various forms of depression often lead to unwanted weight g

Contact: Stephanie Donoho
Eleanor Roosevelt Institute

Page: 1 2

Related biology news :

1. Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin
2. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
3. Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins
4. Landmark conference for United Nations on human cloning and stem cell research
5. Landmark study offers new information about breast cancer genes
6. Landmark completion of comprehensive index of human proteins to be presented at New York Academy of Sciences
7. Radical discovery dedicated a National Historic Chemical Landmark
8. Landmark progress in understanding ribosome structure-- research done at Brookhaven Labs light source
9. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
10. 16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
11. Marathoning mice could have Olympian effects on obesity

Post Your Comments:

(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: