Landmark progress in understanding ribosome structure-- research done at,,Brookhaven Lab's light source

Upton, NY--Two reports in the August 26 issue of the scientific journal Nature describe landmark progress in understanding the structure of the ribosome. The ribosome is a complex particle that makes the thousands of proteins that are required for the structure and function of each living cell. Both Nature reports are based on data generated by a scientific technique called x-ray crystallography, performed at the National Synchrotron Light Source, operated by the U.S. Department of Energy's Brookhaven National Laboratory.

The ribosome is the largest and most complex component of a cell to be successfully studied via x-ray crystallography. Researchers from the University of Utah; the Medical Research Council Laboratory of Molecular Biology, Cambridge, England; and Brookhaven Lab presented a model of the small ribosomal subunit known as 30S, from the bacterium Thermus thermophilus. Yale University and Brookhaven researchers reported on the structure of the large ribosomal subunit known as 50S, from the bacterium Haloarcula marismortui. These two independent research efforts point the way for future study of large ribosome complexes.

Malcolm Capel, a Brookhaven National Laboratory biophysicist who is a co-author on both Nature papers, explained, "This research is a technical and scientific tour de force. On a basic science level, these findings represent a giant step on the road to understanding how living organisms make proteins. On a more practical level, many bacterial infections are stopped by antibiotics, which work by inhibiting the production of ribosomes in bacterial cells. Better structural knowledge of ribosomes may lead to developing more effective antibiotics through computer-modeling. Also, ribosomes are used by industry to make important enzymes, which promote chemical reactions. This new structural information may be helpful for developing further industrial applications."

To gain this new data, the researchers grew crystals

Contact: Diane Greenberg
DOE/Brookhaven National Laboratory

Page: 1 2 3

Related biology news :

1. Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin
2. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
3. Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins
4. Landmark conference for United Nations on human cloning and stem cell research
5. Landmark study offers new information about breast cancer genes
6. Landmark completion of comprehensive index of human proteins to be presented at New York Academy of Sciences
7. Radical discovery dedicated a National Historic Chemical Landmark
8. Landmark obesity study
9. New molecular link key to cellular proteins involved in cancer progression, other diseases
10. A new protein is discovered to play a key role in cancer progression
11. Progress in breast cancer progression

Post Your Comments:

(Date:4/30/2020)... WESTBURY, N.Y. (PRWEB) , ... April 28, 2020 ... ... clients, these webinars are Lachman Consultants latest effort in providing timely and critical ... environment, further complicated by social distancing and health safety concerns. , “Providing the ...
(Date:4/23/2020)... ... April 23, 2020 , ... Despite the current COVID-19 environment, ... products for the animal feed, human consumption, wastewater, and biotech sectors, and demand ... channels from overseas competitors have become weakened or shut down completely, new inquiries ...
(Date:4/18/2020)... ... 2020 , ... SIRION Biotech GmbH , a world leader in viral ... a company update on its work expediting gene therapy research and advancing drug development ... and 23. Dieter Lingelbach, the Company’s Chief Operating Officer, will also provide an update ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... , ... May 14, 2020 ... ... of human mesenchymal stem/stromal cell (hMSC) working cell banks and hMSC bioprocess ... enable streamlined and multi-format collection of hMSC-derived extracellular vesicles (EVs). RoosterCollect™-EV-CC is ...
(Date:5/14/2020)... ... May 12, 2020 , ... NanoString ... bringing together thousands of industry leaders, clinicians, research scientists, medical professionals and academics ... Carl June, MD, Director of the Center for Cellular Immunotherapies at the Perelman ...
(Date:5/5/2020)... ... May 05, 2020 , ... ProductLife Group has marked the next ... the group after 13 years at Altran, where he was Group VP of Life ... and being a Pharmacist, Xavier was involved in his early career in the development ...
(Date:4/22/2020)... Mass. (PRWEB) , ... April 20, 2020 , ... ... US offices in Cambridge, MA, announced today that Omixon’s founder and chairman Dr. ... commercialisation of Omixon’s flagship product Holotype HLA since 2014 before stepping into the ...
Breaking Biology Technology:
Cached News: