Landmark progress in understanding ribosome structure-- research done at,,Brookhaven Lab's light source

Upton, NY--Two reports in the August 26 issue of the scientific journal Nature describe landmark progress in understanding the structure of the ribosome. The ribosome is a complex particle that makes the thousands of proteins that are required for the structure and function of each living cell. Both Nature reports are based on data generated by a scientific technique called x-ray crystallography, performed at the National Synchrotron Light Source, operated by the U.S. Department of Energy's Brookhaven National Laboratory.

The ribosome is the largest and most complex component of a cell to be successfully studied via x-ray crystallography. Researchers from the University of Utah; the Medical Research Council Laboratory of Molecular Biology, Cambridge, England; and Brookhaven Lab presented a model of the small ribosomal subunit known as 30S, from the bacterium Thermus thermophilus. Yale University and Brookhaven researchers reported on the structure of the large ribosomal subunit known as 50S, from the bacterium Haloarcula marismortui. These two independent research efforts point the way for future study of large ribosome complexes.

Malcolm Capel, a Brookhaven National Laboratory biophysicist who is a co-author on both Nature papers, explained, "This research is a technical and scientific tour de force. On a basic science level, these findings represent a giant step on the road to understanding how living organisms make proteins. On a more practical level, many bacterial infections are stopped by antibiotics, which work by inhibiting the production of ribosomes in bacterial cells. Better structural knowledge of ribosomes may lead to developing more effective antibiotics through computer-modeling. Also, ribosomes are used by industry to make important enzymes, which promote chemical reactions. This new structural information may be helpful for developing further industrial applications."

To gain this new data, the researchers grew crystals

Contact: Diane Greenberg
DOE/Brookhaven National Laboratory

Page: 1 2 3

Related biology news :

1. Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin
2. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
3. Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins
4. Landmark conference for United Nations on human cloning and stem cell research
5. Landmark study offers new information about breast cancer genes
6. Landmark completion of comprehensive index of human proteins to be presented at New York Academy of Sciences
7. Radical discovery dedicated a National Historic Chemical Landmark
8. Landmark obesity study
9. New molecular link key to cellular proteins involved in cancer progression, other diseases
10. A new protein is discovered to play a key role in cancer progression
11. Progress in breast cancer progression

Post Your Comments:

(Date:9/3/2020)... ... September 03, 2020 , ... ... announced that an extensive third-party assessment of the company’s security practices has been ... against federal security regulations. The comprehensive evaluation reviewed Litmus’ processes and systems, assessing ...
(Date:8/26/2020)... ... August 25, 2020 , ... ... targeting mitochondria, in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in ... 3 VISTA-2 study of SkQ1 ophthalmic solution in patients with moderate to ...
(Date:8/26/2020)... (PRWEB) , ... August 25, 2020 , ... Modality ... made Inc. magazine’s 2020 annual Inc. 5000 list. The list is the most prestigious ... in 2019 as well, and for this year’s list, reported three-year revenue growth of ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... R3 Stem Cell International is now offering patients the ... stem cells total, patients may choose which extremities they would like treated. , Several ... Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a lab ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... entered into a strategic partnership whereby Catalent will provide support for the development, ...
(Date:7/22/2020)... ... 22, 2020 , ... Join experts from Reed Tech , Gary Saner, ... a one hour live webinar on Thursday, August 13, 2020 at 11am ... and medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical ...
(Date:7/18/2020)... ... 2020 , ... dicentra , a leading Contract Research ... is pleased to announce that Charles Galea has joined its clinical trials division ... an accomplished and results-driven sales executive with over 10 years of expertise in ...
Breaking Biology Technology:
Cached News: