Landmark progress in understanding ribosome structure-- research done at,,Brookhaven Lab's light source

of ribosomes, and, to protect them from radiation damage, froze them to -173°C. Crystals provided the researchers with molecules that are arranged in a regularly repeated pattern for their studies. An intense x-ray beam from the Light Source penetrated the crystal, resulting in tens of thousands of diffraction spots on a computerized imaging detector. The researchers measured the position and intensity of each spot, and then mathematically calculated the electron density of the sample. From these data, they were able to build a molecular model of the ribosomal structure.

Specifically, the ribosome translates the genetic code of nucleic acids known as messenger RNAs into chains of amino acids that make up proteins. The 30S ribosomal subunit recognizes messenger RNA and insures that the sequence of information in the RNA is correctly copied into a protein. The 50S subunit performs the chemical steps involved in linking together amino acids to form proteins. The 30S and 50S subunits work together to generate proteins in all living cells.

Both Nature papers report on structural components at a resolution of five angstroms, a measurement that is about one ten-thousandth the thickness of a human hair. While ribosomes make proteins, they are also composed of proteins and RNA themselves, and, with this resolution, the researchers were able to differentiate a protein from the ribosomal complex. In addition, the surface topology of both subunits is revealed in detail, showing the way the two subunits fit together to form a whole, functional 70S ribosome complex.

The authors of paper describing the ribosome 30S subunit are William M. Clemons, Jr., Joanna L.C. May, Brian T. Wimberly, and John P. McCutcheon from the University of Utah and Venki Ramakrishnan from the University of Utah and the Medical Research Council, Cambridge, England; and Malcolm Capel, from Brookhaven National Laboratory. The research on the large ribosomal 50S subunit is reported b

Contact: Diane Greenberg
DOE/Brookhaven National Laboratory

Page: 1 2 3

Related biology news :

1. Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin
2. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
3. Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins
4. Landmark conference for United Nations on human cloning and stem cell research
5. Landmark study offers new information about breast cancer genes
6. Landmark completion of comprehensive index of human proteins to be presented at New York Academy of Sciences
7. Radical discovery dedicated a National Historic Chemical Landmark
8. Landmark obesity study
9. New molecular link key to cellular proteins involved in cancer progression, other diseases
10. A new protein is discovered to play a key role in cancer progression
11. Progress in breast cancer progression

Post Your Comments:

(Date:5/28/2020)... INDIANAPOLIS (PRWEB) , ... May 27, 2020 , ... ... of hc1 Workforce Advisor™ , a solution that uniquely combines lab testing ... to help employers systematically support the ongoing health and safety of employees returning ...
(Date:5/28/2020)... and FORT WORTH, Texas (PRWEB) , ... May ... ... stage biopharmaceutical company, announced today that interim results from their 1801 Phase 1/2 ... of Clinical Oncology (ASCO) Annual Meeting which will take place virtually on May ...
(Date:5/25/2020)... United Kingdom (PRWEB) , ... May 22, 2020 , ... ... (assay) for the detection of SARS-CoV-2, the virus that causes COVID-19. , ... to on-demand analysis of smaller sample numbers, to very large numbers of samples. ...
Breaking Biology News(10 mins):
(Date:5/21/2020)... ... 21, 2020 , ... Threats to intellectual property, political pressure ... to conventional wisdom that says the coronavirus pandemic will generally benefit biopharmaceutical companies, ... the pandemic commercially weaker, dealing with delays in new product launches and with ...
(Date:5/21/2020)... ... May 20, 2020 , ... Exo ... serve as the company’s executive vice president of product engineering and report directly ... the medical imaging space, bringing more than 24 years of technology leadership experience ...
(Date:5/15/2020)... ... 14, 2020 , ... This new service offers clients a way to speak ... quickly as the need arises. Lachman’s OnCall SMEs have extensive knowledge of a wide ... , Lachman OnCall™ SMEs are available normal business hours Monday through Friday from 9:00 ...
(Date:5/14/2020)... Calif. (PRWEB) , ... May 12, 2020 , ... ... science tools for translational research, is bringing together thousands of industry leaders, clinicians, ... scientific program highlights two plenary speakers, Carl June, MD, Director of the Center ...
Breaking Biology Technology:
Cached News: