HOME >> BIOLOGY >> NEWS
Laser Microscope At Cornell Images Serotonin In Live Cells

ITHACA, N.Y. -- Cornell University researchers, using non-linear laser-microscope technology developed at Cornell, have produced images displaying the neurotransmitter serotonin in live cells in real time, and they have for the first time measured the concentration of serotonin in secretory granules.

The microscope, which uses pulsed lasers for excitation, can record ultraviolet (UV) fluorescence images of live cells without using UV illumination to detect and image cellular activity.

"This technique caught serotonin granules in the act of releasing the substance, without damaging the cell or changing the process and without requiring any external fluorescent marker," said Watt W. Webb, Cornell professor of applied and engineering physics, who led the work. "It is a new way of doing three-dimensional UV microscopy in functioning cells and the best way we know of for doing UV microscopy in thick tissues," Webb said.

The studies were reported in a paper, "Measuring serotonin distribution in live cells with three-photon excitation," published in the journal Science (Jan. 24, 1997) by Webb and Sudipta Maiti, a postdoctoral researcher; Jason B. Shear, former National Science Foundation post doctoral fellow now at the University of Texas at Austin; Rebecca M. Williams, physics graduate student; and Warren R. Zipfel, a research associate, all at Cornell.

Serotonin is a neurotransmitter that is becoming increasingly important as medical science learns of its role in a host of human disorders. It has been implicated in central nervous system disorders such as anxiety, depression, obsessive-compulsive disorder, schizophrenia, stroke, obesity, pain, hypertension, vascular disorders, migraine and even nausea. Serotonin is synthesized in brain neurons and is released upon a nerve impulse, where it interacts with receptors. The antidepressant Prozac (fluoxetine) is thought to treat depression by inhibitin
'"/>

Contact: Larry Bernard
lb12@cornell.edu
607-255-3651
Cornell University News Service
23-Jan-1997


Page: 1 2 3

Related biology news :

1. Laser technique used to build micro-polymeric structure on a human hair, without harming it
2. Laser technology to map industrial plant gases available through Alberta Research Council
3. Lasers create new possibilities for biological technology
4. Laser micro-scalpel yields biological insights into tissue dynamics
5. Laser-pulse technique could aid drug design
6. Researchers at Vanderbilts Free-Electron Laser Center are developing new forms of laser surgery, improved X-ray technology, and better methods for protein identification
7. Laser technique examines movement in nucleus of living cell
8. Laser treatment reduces scarring after heart attack
9. Laser surgery halts chest pain over the long-term; scientists also looking into non-surgical TMR
10. Lasers to the aid of embryos
11. Laser light from Free-Electron Laser used for first time in human surgery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... ... Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 ... but what is the most effective way to complete one? Will the study ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... publication detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test ... 16 minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection ...
(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode ... in accelerated Point of Care Testing solutions (POCT). Check local listings for more info. ... at medical offices and are shipped to labs throughout the country. Results are then ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... sciences industry, today announced the release of its signature product called Beacon ... Liaisons (MSLs) and other field medical professionals. , Beacon helps MSLs ...
(Date:7/18/2020)... ... 17, 2020 , ... dicentra , a leading Contract ... industries, is pleased to announce that Charles Galea has joined its clinical trials ... is an accomplished and results-driven sales executive with over 10 years of expertise ...
(Date:7/7/2020)... , ... July 06, 2020 , ... R3 International is ... featuring up to 200 million stem cells. Depending on the patient's condition, treatment may ... the US will die having some form of Alzheimers dementia, and the incidence continues ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a ... Safe Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with ... , A Safe Space™ enabled business will provide a health performance index system that ...
Breaking Biology Technology:
Cached News: