HOME >> BIOLOGY >> NEWS
Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation

lar biology had yet to be invented.

"This was the Dark Ages," recalls Roeder. "We didn't have many isolated and characterized genes to work with like we do now." For this research he was honored with the American Chemical Society Eli Lilly Award in Biological Chemistry in 1977.

Nature's secrets revealed in test tube In the late 1970s, Roeder developed cell-free systems that allowed him and others to study the function of individual genes and transcription-related proteins outside of living cells, in effect recreating transcription in a test tube in a way that faithfully mimics the real process in cells. Using this powerful test-tube technique, composed of purified RNA polymerases and components extracted from cell nuclei, Roeder identified distinct sets of proteins, called accessory factors, essential for the individual RNA polymerases to recognize start sites on specific target genes.

Significantly, he simultaneously identified the first gene-specific activator, called TFIIIA, in eukaryotes. TFIIIA and similar proteins bind to specific DNA sequences and enhance the "reading" of corresponding target genes by the appropriate subset of the general transcription machinery. Repressors perform the opposite task by inhibiting a gene's activity.

Hundreds of these transcription activators and repressors subsequently have been identified by Roeder and other scientists, and many more are expected for the regulation of genes during such physiological processes as cell growth and division, hormonal processes, virus infection and tumor growth.

"The challenge we now face is understanding the differential regulation of about 30,000 human genes," says Roeder.

Complexity demystified

Over the last decade at Rockefeller University, Roeder and his colleagues have identified several coactivators, thereby ushering in a modern age in biology. Says Roeder, "We have uncovered a third layer of complexity in the transcriptio
'"/>

Contact: Joseph Bonner
bonnerj@mail.rockefeller.edu
212-327-8998
Rockefeller University
13-Sep-2003


Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Clay M. Armstrong, MD, wins 1999 Albert Lasker Basic Medical Research Award
2. Gladstone investigator Mike McCune wins prestigious NIH Directors Pioneer Award
3. UT Southwestern biochemist honored with NIH Directors Pioneer Award
4. Award winning researchers reveal potential new role for Glivec
5. UMaine anthropologist wins Solon T. Kimball Award
6. Secretary of Energy announces seven E.O. Lawrence Award Winners
7. Martin Saunders to receive the James Flack Norris Award
8. Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
9. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
10. Second call for proposals for the European Young Investigator Award
11. Virginia Tech professor honored with DeLaval Award

Post Your Comments:
(Date:4/23/2014)... 2 million Food Standards Agency (FSA) project to map ... workers. , Norovirus outbreaks can rapidly affect large ... frozen strawberries infected 11,000 people in Germany, but there ... strains cause infection and which foods are the most ... will produce data that will help the FSA to ...
(Date:4/22/2014)... Yale researchers will lead a five-year, $3 million study ... is affecting the transport of dissolved organic matter (DOM) ... could alter the chemical composition and water quality of ... from the National Science Foundation,s MacroSystems Biology program, researchers ... watershed, which begins in Canada and runs through five ...
(Date:4/22/2014)... RIVERSIDE, Calif. Inspired by the fist-like club ... by University of California, Riverside, in collaboration with University ... design structure for composite materials that is more impact ... , "The more we study the club of this ... improve so many things we use every day," said ...
Breaking Biology News(10 mins):Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3Mantis shrimp stronger than airplanes 2Mantis shrimp stronger than airplanes 3
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... 2014 2013 was a banner year ... Technologies®. They saw continued independent research led by the ... awarded a $1 million grant from the Susanne Marcus ... Behavior” a peer reviewed journal, Amy Grant highlighted Brainwave ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
Cached News: