HOME >> BIOLOGY >> NEWS
Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation

lar biology had yet to be invented.

"This was the Dark Ages," recalls Roeder. "We didn't have many isolated and characterized genes to work with like we do now." For this research he was honored with the American Chemical Society Eli Lilly Award in Biological Chemistry in 1977.

Nature's secrets revealed in test tube In the late 1970s, Roeder developed cell-free systems that allowed him and others to study the function of individual genes and transcription-related proteins outside of living cells, in effect recreating transcription in a test tube in a way that faithfully mimics the real process in cells. Using this powerful test-tube technique, composed of purified RNA polymerases and components extracted from cell nuclei, Roeder identified distinct sets of proteins, called accessory factors, essential for the individual RNA polymerases to recognize start sites on specific target genes.

Significantly, he simultaneously identified the first gene-specific activator, called TFIIIA, in eukaryotes. TFIIIA and similar proteins bind to specific DNA sequences and enhance the "reading" of corresponding target genes by the appropriate subset of the general transcription machinery. Repressors perform the opposite task by inhibiting a gene's activity.

Hundreds of these transcription activators and repressors subsequently have been identified by Roeder and other scientists, and many more are expected for the regulation of genes during such physiological processes as cell growth and division, hormonal processes, virus infection and tumor growth.

"The challenge we now face is understanding the differential regulation of about 30,000 human genes," says Roeder.

Complexity demystified

Over the last decade at Rockefeller University, Roeder and his colleagues have identified several coactivators, thereby ushering in a modern age in biology. Says Roeder, "We have uncovered a third layer of complexity in the transcriptio
'"/>

Contact: Joseph Bonner
bonnerj@mail.rockefeller.edu
212-327-8998
Rockefeller University
13-Sep-2003


Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Clay M. Armstrong, MD, wins 1999 Albert Lasker Basic Medical Research Award
2. Gladstone investigator Mike McCune wins prestigious NIH Directors Pioneer Award
3. UT Southwestern biochemist honored with NIH Directors Pioneer Award
4. Award winning researchers reveal potential new role for Glivec
5. UMaine anthropologist wins Solon T. Kimball Award
6. Secretary of Energy announces seven E.O. Lawrence Award Winners
7. Martin Saunders to receive the James Flack Norris Award
8. Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
9. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
10. Second call for proposals for the European Young Investigator Award
11. Virginia Tech professor honored with DeLaval Award

Post Your Comments:
(Date:10/17/2014)... German . ... When treating overdoses, doctors are often limited to supportive therapy ... is a combination of drugs involved. So what can be ... grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute of ... to this question. "The task was to develop an agent ...
(Date:10/16/2014)... can be cultivated efficiently, they are anything but ... by monoculture cultivation is becoming increasingly evident. Despite ... form and are regarded as the sole possibility ... quite wrongfully, finds Bernhard Schmid, an ecology professor ... novel form of agriculture and forestry. After all, ...
(Date:10/15/2014)... assess the pandemic risk from strains of influenza virus ... allow ourselves to become complacent that the most substantial ... scientists. , Influenza pandemics arise when a new virus ... widespread immunity – spreads in the human population. There ... years, the worst of which – the 1918 Spanish ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
(Date:10/22/2014)... The Americas Inorganic Refrigerants Market ... in Americas with analysis and forecast of revenue. ... Inorganic Refrigerants Market report, to get an idea ... a glimpse of the segmentation in the Americas ... tables and figures. , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html ...
(Date:10/22/2014)... October 21, 2014 Shimadzu Scientific Instruments ... data tool for the pain management and clinical markets. ... processing and review by allowing users to highlight and ... , QuantAnalytics allows analysts to filter results by ... data processing by eliminating the need to sift through ...
(Date:10/22/2014)... WriteResult, LLC – a premier provider of ... a team of researchers from Yale University’s School of ... to provide electronic questionnaire data collection through use of ... in May, aims to evaluate the impact of a ... and participation in urban agriculture to impact their consumption ...
(Date:10/22/2014)... 22, 2014 Grace Century, a private ... projects, announces the addition of Dr. Yousef “Josh” ... advisory team. Dr. Siddiqui will provide further healthcare expertise ... graduate of University College Medical School in ... medicine in 2001. With further certification as a General ...
Breaking Biology Technology:The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2
Cached News: