in the DNA of mice fed a suspected carcinogen found in grilled meat. With researchers from the UC Davis College of Agriculture and Environmental Sciences, they plan to study anticancer compounds found in broccoli and other plants to see if they can prevent these cancerous changes.
* Ultrasensitive pharmacokinetic studies using accelerator mass spectroscopy that analyze how well drugs are absorbed in the body. This study shows promise in helping physicians to fine-tune chemotherapy dosages based on an individual's metabolism, lessening toxicity and improving chemotherapy effectiveness. Physician-researchers in the cancer center's Division of Hematology/Oncology will work with Lawrence Livermore scientists in creating human protocols.
* The development of new light diffusion sensors that can detect cancer by measuring how light scatters when it is reflected inside tissue. Placed at the end of a cystoscope, the sensor could detect bladder cancer without a surgical biopsy. Lawrence Livermore physicist Stavros Demos will work with deVere White, chair of the Department of Urology at the UC Davis School of Medicine and Medical Center, on this project.
* The development of an ultra-short-pulse laser to use the light scatter off tissue to create images that show melanomas and other cancers on the surface of the skin.

The process uses the tendency of normal tissue to convert laser light to a higher frequency, a quality cancerous tissue does not have. Beop-Min Kim of Lawrence Livermore and Dr. Karen Reiser, a research scientist in the Department of Neurological Surgery at the UC Davis Medical Center, are collaborating on this project.

The cancer agreement, formalized by a memorandum of understanding, calls for joint leadership, including adjunct academic appointments to UC Davis. Some Lawrence Livermore scientists will be named associate directors of the UC Davis Cancer Center or will be named principal investigators of research initiatives, both to b
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Contact: Stephen Wampler
wampler1@llnl.gov
925-423-3107
DOE/Lawrence Livermore National Laboratory
1-Nov-2000

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