PHILADELPHIA David S. Alberts, M.D., Regents Professor of Medicine, Pharmacology, Nutritional Science, and Public Health at the University of Arizona College of Medicine, and Director of the Cancer Prevention and Control Program at the Arizona Cancer Center, Tucson, is the recipient of the 2004 American Association for Cancer Research (AACR)-Cancer Research and Prevention Foundation (CRPF) Award for Excellence in Cancer Prevention Research. He is among the first in cancer research to begin studying in the laboratory those basic chemical agents and nutrients with the potential to treat or prevent cancer, and then to take them through pharmacological development and on to clinical trials in patients.

"Dr. Alberts is a true pioneer in translational cancer prevention research," said Margaret Foti, Ph.D., M.D. (h.c.), AACR chief executive officer.

"His many contributions to the field have advanced cancer prevention from its earliest preclinical and clinical stages of drug development to definitive, randomized controlled trials. His laboratory and clinical research has emphasized the chemoprevention and treatment of such pervasive and potentially deadly diseases as breast, colon, ovarian, and skin cancer."

Beginning in the 1970s, Dr. Alberts conducted landmark studies on the analytical chemistry and pharmacokinetics of retinoids derived from Vitamin A. Results of clinical trials in more than 2,200 patients led to the finding that retinol is effective in preventing squamous cell skin cancer. Following this work, he developed a panel of biomarkers of skin carcinogenesis, including proliferating cell nuclear antigen (PCNA), p53, polyamine levels, and apoptosis. Together with his research group, the Chemoprevention of Skin Cancer Program Project, he developed topically administered chemopreventive agents that can be incorporated into sunscreens.

Dr. Alberts also published an important study which rejected the hypothesis that dietary supple
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Contact: Sheri Ozard
ozard@aacr.org
215-440-9300
American Association for Cancer Research
30-Sep-2004

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