HOME >> BIOLOGY >> NEWS
Learning how organs tell left from right

September 16, 1999--From all outward appearances, the human body is symmetrical. If one were to divide the body into two halves, for example, each side would have a single arm and leg. But a look inside at the internal organs shows that there is not perfect symmetry throughout the body. The heart and spleen normally reside on the left side and the liver and gallbladder are on the right. Furthermore, the organs themselves are asymmetrical.

Understanding how genes control the shape and spatial orientation of organs is one of the goals of developmental biologists. In the mouse as in other vertebrates, cells begin receiving and responding to instructions about their positional fate during the earliest stages of development, when the embryo resembles little more than a flat sheet of cells. Two proteins in particular, called Nodal and Pitx2, are produced predominantly on the left side of the mouse embryo and they appear to direct the growth of organs in a way that is appropriately "left-sided." Understanding how these two proteins interact may allow scientists to understand a great deal more about how organs are segregated into left-side and right-side.

In attempting to unravel the genetic program that determines left/right orientation, Howard Hughes Medical Institute (HHMI) investigator Michael Rosenfeld and colleagues at the University of California, San Diego, and The Salk Institute, engineered knockout mice that lacked the Pitx2 gene. The mice exhibited a number of developmental abnormalities, including inappropriate position of the heart and lungs.

Humans with one defective copy of the Pitx2 gene have a constellation of problems called Rieger syndrome, the signs of which include irregularly shaped eyes, lack of tooth growth, craniofacial deformities, and, more rarely, problems with growth hormone production.

Rosenfeld's team found that Pit
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
16-Sep-1999


Page: 1 2 3

Related biology news :

1. Clemson launches S.C. DNA Learning Center
2. Learning opportunities expand using GIS data
3. Learning how cells tiny motor powers its mobility
4. Learning is growing: scientists investigate the links between memory and brain development
5. Jefferson Scientists Find Link Between Learning And Preventing Alzheimers
6. Williams Syndrome: UD Research Pinpoints Language And Learning Traits Of Those With The Disorder
7. Learning To Feel Chronic Pain
8. Learning About Evolution Critical For Understanding Science
9. Uterine Environment Boosts Learning Ability In Mouse Offspring
10. Carnegie Mellon Researchers Say Direct Instruction, Rather Than "Discovery Learning" Is Best Way To Teach Process Skills In Science
11. Learning From Birds And Bees: Engineers Study Insects For Ideas On Tiny "Micro Air Vehicles"

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... Litmus ... an extensive third-party assessment of the company’s security practices has been completed. The ... security regulations. The comprehensive evaluation reviewed Litmus’ processes and systems, assessing them to ...
(Date:8/26/2020)... ... August 25, 2020 , ... Catalent, ... drugs, biologics, cell and gene therapies, and consumer health products, today announced that ... Virtual Conference & Expo, taking place between Aug. 31 – September 4, 2020. ...
(Date:8/21/2020)... (PRWEB) , ... August 18, 2020 , ... ... to cell therapy, today announced that the U.S. Food and Drug Administration (FDA) ... Sentien’s lead asset, SBI-101, for the treatment of severe COVID-19. Approval of this ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the solution ... history of eSource, the reasons it did not take off as quickly as people ... the industry is moving towards capturing data electronically for clinical trials and then repurposing ...
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter maintenance and ... successful study, while protecting and accessing the catheter or device post-surgery is often undervalued ... Envigo in a live webinar on Wednesday, August 5, 2020 at ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, a ... laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and virus-management ...
(Date:7/7/2020)... ... ... R3 International is now offering stem cell therapy for Alzheimers dementia in Mexico ... patient's condition, treatment may be offered IV, intrathecal or with a combination. , A ... and the incidence continues to increase as individuals live longer. There is no cure, ...
Breaking Biology Technology:
Cached News: