HOME >> BIOLOGY >> NEWS
Lehigh scientists believe they have found link between DHEA and central nervous system

DHEA - dehydroepiandrosterone - has been called the "Mother Hormone" and hailed as the new Fountain of Youth. The most abundant steroid hormone produced by the body, its enthusiasts claim it can help people stay thin, build muscle, reduce stress, improve memory and prevent killer diseases.

But the verdict is still out on synthetic DHEA, which was banned by the Food and Drug Administration in the 1980s and can now be sold only as a food supplement.

Now, researchers at Lehigh University believe they have established a possible cause-and-effect relationship between DHEA and the workings of the body's central nervous system.

Neal Simon, chair of the biological sciences department at Lehigh, says he and his colleagues have discovered the "genomic effect" of DHEA, or its influence at a cell's genetic level. By contrast, says Simon, most of the other research into neurosteroids has focused on their activity at the cell surface.

"We are one of only a few groups - to the best of my knowledge - that has demonstrated a genomic effect of DHEA in the central nervous system. This finding opens up a wide range of possibilities regarding how DHEA produces its effect as a neurosteroid. You have to consider a host of other effects it might produce." Two of those effects could be improved survival of neurons, or nerve cells, or increased neurite outgrowth, which could contribute to improved cognition and memory.

Simon and his group are particularly interested in the interaction between DHEA and androgen, the hormone that stimulates the development of sex characteristics in males. "We have looked at DHEA's structure, and at metabolic pathways in cells, to determine what effects androgen might have at the genetic level," says Simon. "We are the first lab to demonstrate that DHEA can act to regulate gene function by interacting with androgen receptors, either by itself or after its conversion to other androgens. This is a very new view of how
'"/>

Contact: William Johnson
wjj0@lehigh.edu
610-758-3172
Lehigh University
9-Jan-2002


Page: 1 2 3

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... 2, 2017 Summary This report provides ... its partnering interests and activities since 2010. ... Read the full report: ... since 2010 report provides an in-depth insight into the partnering ... On demand company reports are prepared upon purchase ...
(Date:3/2/2017)... 2017 Who risk to be deprived of ... full report: https://www.reportbuyer.com/product/4313699/ WILL APPLE AND ... Fingerprint sensors using capacitive technology represent a fast ... Idex forecasts an increase of 360% of the number ... the fingerprint sensor market between 2014 and 2017 (source ...
(Date:3/1/2017)... -- Aware, Inc. (NASDAQ: AWRE), a leading supplier of biometrics ... has resigned, effective March 3, 2017, as co-Chief ... Treasurer of Aware citing a desire to retire.  Mr. ... the Board of Directors of Aware. ... co-President, General Counsel has been named Chief Executive Officer, ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... Pa. , March 29, 2017 Patients ... which is why CSL Behring awards Local Empowerment for ... rare disease patient groups. These groups tackle complex legislative ... heard on Capitol Hill and in statehouses across the ... the community-based grant was awarded to New England Hemophilia ...
(Date:3/29/2017)... , and HILDEN, Germany , March 29, 2017 /PRNewswire/ ... FRANKFURT PRIME STANDARD: QIA) today announced the U.S. launch of ... JAK2 assay), which was cleared by the U.S. Food and Drug Administration as ... allele in genomic DNA extracted from EDTA whole blood.* ... The ipsogen JAK2 assay is processed on QIAGEN,s Rotor-Gene ...
(Date:3/29/2017)... 29, 2017 /PRNewswire/ - Last year,s petition to the White ... only efforts active to generate awareness on the importance of new ... in the healthcare market place. ... Earlier this month Health Advance (OTC ... pharmaceutical and nutritional products, announced its endeavors on this generally ...
(Date:3/29/2017)... N.J. and PETACH TIKVAH, ...  BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), ... technologies for neurodegenerative diseases, announced financial results ... "2016 was a highly successful ... important achievements and significant progress made on ...
Breaking Biology Technology:
Cached News: