HOME >> BIOLOGY >> NEWS
Lehigh scientists believe they have found link between DHEA and central nervous system

DHEA - dehydroepiandrosterone - has been called the "Mother Hormone" and hailed as the new Fountain of Youth. The most abundant steroid hormone produced by the body, its enthusiasts claim it can help people stay thin, build muscle, reduce stress, improve memory and prevent killer diseases.

But the verdict is still out on synthetic DHEA, which was banned by the Food and Drug Administration in the 1980s and can now be sold only as a food supplement.

Now, researchers at Lehigh University believe they have established a possible cause-and-effect relationship between DHEA and the workings of the body's central nervous system.

Neal Simon, chair of the biological sciences department at Lehigh, says he and his colleagues have discovered the "genomic effect" of DHEA, or its influence at a cell's genetic level. By contrast, says Simon, most of the other research into neurosteroids has focused on their activity at the cell surface.

"We are one of only a few groups - to the best of my knowledge - that has demonstrated a genomic effect of DHEA in the central nervous system. This finding opens up a wide range of possibilities regarding how DHEA produces its effect as a neurosteroid. You have to consider a host of other effects it might produce." Two of those effects could be improved survival of neurons, or nerve cells, or increased neurite outgrowth, which could contribute to improved cognition and memory.

Simon and his group are particularly interested in the interaction between DHEA and androgen, the hormone that stimulates the development of sex characteristics in males. "We have looked at DHEA's structure, and at metabolic pathways in cells, to determine what effects androgen might have at the genetic level," says Simon. "We are the first lab to demonstrate that DHEA can act to regulate gene function by interacting with androgen receptors, either by itself or after its conversion to other androgens. This is a very new view of how
'"/>

Contact: William Johnson
wjj0@lehigh.edu
610-758-3172
Lehigh University
9-Jan-2002


Page: 1 2 3

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 8.8% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
(Date:3/20/2017)... PMD Healthcare announces the release of its ... System (WMS), a remote, real-time lung health monitoring and ... is a Medical Device, Digital Health, and Chronic Care ... innovative solutions that empower people to improve their healthcare ... developed the first ever personal spirometer, Spiro PD, which ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... 2017 , ... Energetiq Technology, a world leader in high ... accommodate its rapid growth. , The renovations at the company’s headquarters in Woburn, ... areas. The expansion includes, a state-of-the-art engineering facility, and a second clean manufacturing ...
(Date:5/22/2017)... ... May 22, 2017 , ... Stratevi, a boutique firm that partners with healthcare ... has opened an office in downtown Boston at 745 Atlantic Ave. , “We ... to generate evidence on the value they provide, not just to patients, but also ...
(Date:5/19/2017)... ... 19, 2017 , ... In response to the strong base of evidence supporting ... announces the release of their Gait Trainer 3 with an Integrated Music Therapy option. ... to aid in rehabilitating individuals with cerebral palsy, traumatic brain injury, stroke and Parkinson’s ...
(Date:5/18/2017)... ... ... NDA Partners Chairman Carl Peck, MD , announced today that Richard ... of Pharmaceutical Development Business Unit of Cardinal Health, has joined the firm as an ... former Chief Operating Officer at Anaborex, Senior VP and General Manager of the San ...
Breaking Biology Technology:
Cached News: