HOME >> BIOLOGY >> NEWS
Lehigh scientists believe they have found link between DHEA and central nervous system

DHEA - dehydroepiandrosterone - has been called the "Mother Hormone" and hailed as the new Fountain of Youth. The most abundant steroid hormone produced by the body, its enthusiasts claim it can help people stay thin, build muscle, reduce stress, improve memory and prevent killer diseases.

But the verdict is still out on synthetic DHEA, which was banned by the Food and Drug Administration in the 1980s and can now be sold only as a food supplement.

Now, researchers at Lehigh University believe they have established a possible cause-and-effect relationship between DHEA and the workings of the body's central nervous system.

Neal Simon, chair of the biological sciences department at Lehigh, says he and his colleagues have discovered the "genomic effect" of DHEA, or its influence at a cell's genetic level. By contrast, says Simon, most of the other research into neurosteroids has focused on their activity at the cell surface.

"We are one of only a few groups - to the best of my knowledge - that has demonstrated a genomic effect of DHEA in the central nervous system. This finding opens up a wide range of possibilities regarding how DHEA produces its effect as a neurosteroid. You have to consider a host of other effects it might produce." Two of those effects could be improved survival of neurons, or nerve cells, or increased neurite outgrowth, which could contribute to improved cognition and memory.

Simon and his group are particularly interested in the interaction between DHEA and androgen, the hormone that stimulates the development of sex characteristics in males. "We have looked at DHEA's structure, and at metabolic pathways in cells, to determine what effects androgen might have at the genetic level," says Simon. "We are the first lab to demonstrate that DHEA can act to regulate gene function by interacting with androgen receptors, either by itself or after its conversion to other androgens. This is a very new view of how
'"/>

Contact: William Johnson
wjj0@lehigh.edu
610-758-3172
Lehigh University
9-Jan-2002


Page: 1 2 3

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
(Date:4/9/2015)... Synaptics Inc. (NASDAQ: SYNA ), a leading ... will report financial results for the third quarter of ... close of market. The company will host a corresponding ... PT (5:00 p.m. ET), during which management may discuss ... live call, analysts and investors should dial 888-438-5524 (conference ...
(Date:4/2/2015)... -- According to preliminary estimates Fingerprint Cards, ... than 125 MSEK. This exceeds the guidance provided by ... for Q1 2015 would be in line with the ... The operating result for the first quarter is estimated ... will as previously communicated be published on May 21. ...
(Date:3/31/2015)...   Guidepoint , a leading global research services ... Management TRACKER, part of the Guidepoint TRACKER ... medical device and therapeutics markets. The Post-Surgical Pain Management ... market share, and adoption rates across three major modalities ... The Post-Surgical Pain Management TRACKER will provide ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
(Date:4/23/2015)... Florida (PRWEB) April 23, 2015 ... it intends to conduct a groundbreaking pilot study ... to be reversed in as little as three ... science of metabolic and nutritional medicine—will aggressively target ... cripple and destroy our aging brain. These include ...
(Date:4/23/2015)... BioTE Medical President and Founder Gary ... Happier - Avoiding Over-Medication through Natural Hormone Balance" (ISBN: ... Conference at JW Marriott / Ritz Carlton Grande Lakes ... Live Happier, is a welcomed response to many men ... a higher quality of life thanks to bio-identical hormone ...
(Date:4/23/2015)...  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... 2015 results before the Nasdaq market opens on Thursday, ... call and webcast to discuss its financial results and ... at 8:00 a.m. Eastern Time (5:00 a.m. Pacific Time). ... by dialing 866-952-1906 (US) or 785-424-1825 (International) using the ...
(Date:4/23/2015)... Follow us on LinkedIn ... of genetic tests that determine individual susceptibility to ... Huntington's disease, and Alzheimer's disease. Predictive diagnostics are ... interaction in diseased tissue/cells to understand and determine ... response to treatment, such as in the numerous ...
Breaking Biology Technology:New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3
Cached News: