HOME >> BIOLOGY >> NEWS
Leishmania mutant provides insight into disease and may lead to a vaccine

St. Louis, Aug. 28, 2003 -- Researchers at Washington University School of Medicine in St. Louis have shown that Leishmania parasites engineered to lack molecules known as phosphoglycans do not cause disease in genetically susceptible mice. The mutant parasites did, however, survive.

The findings, published in the Aug. 29 issue of the journal Science, may provide an efficient way to study how Leishmania normally persists in the body without triggering symptoms. They also provide new insight into how the parasite causes a disease called leishmaniasis in some individuals and could potentially lead to the development of a vaccine.

"Somehow the persistent Leishmania mutant has found a 'safe' niche within the body that allows the parasite to survive without causing disease and at the same time preventing additional infection," says lead investigator Stephen M. Beverley, Ph.D., the Marvin A. Brennecke Professor and head of the Department of Molecular Microbiology. "This is exactly what happens in normal persistent infections. But we don't know what these persistent parasites look like, what kind of cell they infect or how they interact with the immune system. Our mutant parasite may help answer those questions."

An estimated 12 million people are infected with Leishmania parasites worldwide. Usually the immune system controls the infection and prevents development of leishmaniasis, a disfiguring and sometimes fatal disease. But for some people, such as those with AIDS who have a suppressed immune system, the parasites become active and trigger leishmaniasis. In fact, the disease is a common complication of AIDS in endemic regions including the Mediterranean basin and Southern Europe.

Persistent parasite infections are usually difficult to study, according to Beverley, because it can take six months to a year to establish the persistent infection before research can begin. Postdoctoral researcher and first author Gerald Spth, Ph.D, avoid
'"/>

Contact: Gila Z. Reckess
reckessg@msnotes.wustl.edu
314-286-0109
Washington University School of Medicine
28-Aug-2003


Page: 1 2

Related biology news :

1. Component of fly saliva makes promising Leishmaniasis vaccine
2. Experimental drug shown to block mutant protein causing blood disease
3. Researchers discover why mutant gene causes colon cancer
4. Common genetic damages in non-dividing cells lead to the creation of mutant proteins
5. Patent issued to U-Iowa for mutant chicken pox virus
6. Pavlovs flies: Researchers identify fruit fly memory mutants
7. New mutant mouse repositories established for biomedical researcher community
8. UNC selected as one of two regional mutant mouse resource centers in nation
9. Study by Israeli scientists provides insight on DNA code
10. Study by Tufts biologist provides window into progression of some degenerative diseases
11. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
(Date:3/24/2017)... 2017 Research and Markets has announced the ... & Trends - Industry Forecast to 2025" report to their ... The Global ... CAGR of around 15.1% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief ... ), Inc. has been selected for membership in ARCS Alumni Hall of ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading provider ... nationwide oncology Clinical Nurse Educator (CNE) network, which will launch ... for communication among health care professionals to enhance the patient ... office staff, and other health care professionals to help women ... cancer. ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking ... initiative announced today. The bold new look is part of a transformation to ... into a significant growth period. , It will also expand its service offering from ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
Breaking Biology Technology:
Cached News: