HOME >> BIOLOGY >> NEWS
Leishmania mutant provides insight into disease and may lead to a vaccine

St. Louis, Aug. 28, 2003 -- Researchers at Washington University School of Medicine in St. Louis have shown that Leishmania parasites engineered to lack molecules known as phosphoglycans do not cause disease in genetically susceptible mice. The mutant parasites did, however, survive.

The findings, published in the Aug. 29 issue of the journal Science, may provide an efficient way to study how Leishmania normally persists in the body without triggering symptoms. They also provide new insight into how the parasite causes a disease called leishmaniasis in some individuals and could potentially lead to the development of a vaccine.

"Somehow the persistent Leishmania mutant has found a 'safe' niche within the body that allows the parasite to survive without causing disease and at the same time preventing additional infection," says lead investigator Stephen M. Beverley, Ph.D., the Marvin A. Brennecke Professor and head of the Department of Molecular Microbiology. "This is exactly what happens in normal persistent infections. But we don't know what these persistent parasites look like, what kind of cell they infect or how they interact with the immune system. Our mutant parasite may help answer those questions."

An estimated 12 million people are infected with Leishmania parasites worldwide. Usually the immune system controls the infection and prevents development of leishmaniasis, a disfiguring and sometimes fatal disease. But for some people, such as those with AIDS who have a suppressed immune system, the parasites become active and trigger leishmaniasis. In fact, the disease is a common complication of AIDS in endemic regions including the Mediterranean basin and Southern Europe.

Persistent parasite infections are usually difficult to study, according to Beverley, because it can take six months to a year to establish the persistent infection before research can begin. Postdoctoral researcher and first author Gerald Spth, Ph.D, avoid
'"/>

Contact: Gila Z. Reckess
reckessg@msnotes.wustl.edu
314-286-0109
Washington University School of Medicine
28-Aug-2003


Page: 1 2

Related biology news :

1. Component of fly saliva makes promising Leishmaniasis vaccine
2. Experimental drug shown to block mutant protein causing blood disease
3. Researchers discover why mutant gene causes colon cancer
4. Common genetic damages in non-dividing cells lead to the creation of mutant proteins
5. Patent issued to U-Iowa for mutant chicken pox virus
6. Pavlovs flies: Researchers identify fruit fly memory mutants
7. New mutant mouse repositories established for biomedical researcher community
8. UNC selected as one of two regional mutant mouse resource centers in nation
9. Study by Israeli scientists provides insight on DNA code
10. Study by Tufts biologist provides window into progression of some degenerative diseases
11. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... Aug. 15 2017   ivWatch LLC , a medical device ... therapy, today announced receipt of its ISO 13485 Certification, the global ... International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection of ... "This is an important milestone ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 /PRNewswire/ ... leader in dairy research, today announced a new collaboration ... reduce the chances that the global milk supply is ... dairy project, Cornell University has become the newest academic ... Supply Chain, a food safety initiative that includes IBM ...
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... YORBA LINDA, CA (PRWEB) , ... October 11, ... ... adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and ... activation (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions ... over 5.5 million people each year. Especially those living in larger cities are affected ... based in one of the most pollution-affected countries globally - decided to take action. ...
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
Breaking Biology Technology:
Cached News: