HOME >> BIOLOGY >> NEWS
Leptin linked to obesity and blood clots

ANN ARBOR, Mich. High levels of leptin, a hormone produced by fat cells in the body, could explain why obese people develop dangerous blood clots - which can cause heart attacks and strokes more often than people who are not overweight.

The association between obesity and blood clots is well known; but the cause has remained a mystery. Now, new research with mice conducted by scientists at the University of Michigan Medical School and published in the April 3 issue of the Journal of the American Medical Association, indicates that leptin may be responsible.

Our results suggest that clot formation begins with some type of interaction between leptin and the leptin receptor on platelets blood cells which stick together to make clots, says Daniel T. Eitzman, M.D., a cardiologist at the U-M Cardiovascular Center and an assistant professor of internal medicine in the Medical School.

Knowing how to block this leptin-receptor interaction could help prevent heart attacks and strokes in people who are either obese or overweight, which is half the adult population of the United States.

According to Eitzman, leptin released by fat cells regulates body weight in part by suppressing appetite. When leptin levels in blood go up, the brain signals us to stop eating. But the system breaks down for those who are grossly overweight. Since they have more and larger leptin-producing fat cells than thinner people, their leptin levels increase substantially with every pound of additional weight gain. When leptin reaches very high levels in the blood, Eitzman explains, obese people become resistant to leptins signal making them increasingly vulnerable to leptin-induced blood clotting.

While it certainly plays a major role, Eitzman emphasizes that leptin may not be the only factor involved. The link between obesity and cardiovascular disease is very complex, and there is much we dont know about how other blood clotting factors are regulated in o
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
2-Apr-2002


Page: 1 2 3

Related biology news :

1. Leptin has layers of control
2. Leptin and obesity
3. Leptin rewires the brains feeding circuits
4. Leptin may hold key to better weight loss
5. Leptin Regulates Hunger During Energy Deficit In Women
6. Discovery Of Possible New Weight Control Role For Leptin Announced By Yale University School Of Medicine Researchers
7. Resistance To Leptin Contributes To Obesity
8. Genetic mutations linked to the practice of burning coal in homes in China
9. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
10. Protein involved in childhood disorder linked to cancer
11. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... (PRWEB) , ... September 05, 2018 , ... ... Platform for a mAb manufacturing facility late last year, IPS-Integrated Project Services, LLC ... the manufacturing of autologous cell therapies. The iCON solution provides a pre-fabricated modular ...
(Date:8/31/2018)... ... August 30, 2018 , ... R3 Stem Cell, the ... for new clients. The freezers are very convenient for practices to maintain regenerative ... consist of amniotic and umbilical cord tissue. They are stored at -80 degrees ...
(Date:8/31/2018)... ... August 30, 2018 , ... USDM Life Sciences , the ... and healthcare industries, has received the 2018 Services Partner of the Year, Awarded for ... Box SVP of Business Development and Platform Sales, Niall Wall and received by USDM ...
Breaking Biology News(10 mins):
(Date:9/12/2018)... ... September 11, 2018 , ... ... add flat sheet Forward Osmosis (FO) membranes from Fluid Technology Solutions (FTS H2O) ... by FTS H2O are constructed from cellulose triacetate (CTA) material. The highly hydrophilic ...
(Date:9/7/2018)... ... September 06, 2018 , ... The Discovery on ... meeting of “The industry’s preeminent event on novel drug targets.” BellBrook Labs’ high ... to study these emerging targets in a quest to find new treatments for ...
(Date:9/7/2018)... ... September 06, 2018 , ... Akadeum Life Sciences today announced it has ... an executive and leader of numerous biotech companies. , He most recently served ... acquired by Thompson Street Capital in St. Louis, MO. Prior to ISTO, he ...
(Date:8/31/2018)... ... August 30, 2018 , ... Small, wireless and networked describes more than ... getting connected, too. Draper’s latest system is tiny in size, but is poised to ... factor in the new implant design is the growing awareness that disease often involves ...
Breaking Biology Technology:
Cached News: