Leptin may hold key to better weight loss

Lack of Leptin a cause of 'plateau' all too familiar to dieters

New York, NY- Dieters know the phenomenon all too well: They cut calories, exercise, and lose some weight but at some point they can't seem to get rid of any more of the excess poundage.

Now researchers from Columbia University College of Physicians & Surgeons, St. Luke's-Roosevelt Hospital Center, and the Weill Medical College of Cornell University, in a study of rats, may have some new clues why the plateau effect occurs and what could be done to overcome it. The findings have led to clinical tests in people.

The investigators theorized that rats--and humans--may not be able to lose weight after a certain amount of dieting, even with drugs or surgery, such as gastric bypass, because the loss of fat decreases the amount of the hormone leptin in the body.

Leptin, a hormone mostly manufactured by fat cells, is present in obese animals (and humans) but as the animal loses fat, levels of the hormone go down. With reduced levels of the leptin, the researchers say, the brain mistakenly thinks the animal needs food and sends signals to the body to slow metabolism down and increase appetite, two conditions that make it harder to fight the battle of the bulge.

Prior research has shown that rats with diet-induced obesity and obese humans both have high levels of leptin. Giving more to them is minimally effective. The researchers in this study, therefore, gave obese rats a mixture of the weight-loss drug sibutramine, known commercially as Meridia, and leptin, to see if the two substances together might help the overweight animals lose weight. The addition of leptin, they believed, would trick the brain into thinking that no weight was being lost.

"By preventing the decrease in leptin levels that normally occurs with weight loss, we theorized that sibutramine would be able to have a greater weight-loss effect," says Carol Boozer, D.Sc., assistant profes

Contact: Annie Bayne
Columbia University Medical Center

Page: 1 2

Related biology news :

1. Leptin has layers of control
2. Leptin and obesity
3. Leptin rewires the brains feeding circuits
4. Leptin linked to obesity and blood clots
5. Leptin Regulates Hunger During Energy Deficit In Women
6. Discovery Of Possible New Weight Control Role For Leptin Announced By Yale University School Of Medicine Researchers
7. Resistance To Leptin Contributes To Obesity
8. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
9. Microbes eat their way to better concrete
10. Computer database being developed at Temple will allow for better inventory of chemicals
11. New and better drugs for tuberculosis goal of UH professor

Post Your Comments:

(Date:2/6/2020)... (PRWEB) , ... February 06, 2020 , ... ... to facilitate access to unique lab-made bioresearch materials, today announced an agreement with ... and plant-based meat and seafood a reality. Under the partnership, terrestrial meat and ...
(Date:1/29/2020)... ... January 29, 2020 , ... Jason Burke has joined CREO, ... providing consulting services for strategy, research and development and data governance to healthcare ... Managing Partner of CREO, an innovative management consulting and advisory firm based in ...
(Date:1/27/2020)... ... January 27, 2020 , ... On Thursday, February 20, 2020 at 10am ... Reed Tech and Richard Castle, Global Account Manager Medical Device at PRISYM ... topics include EU MDR timing deadlines, best practices in creating and submitting product data ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... ... Cambridge, MA, announce that OmniType, the 11-locus, single tube multiplex successor to Holotype ... a best-in-class product featuring locus-multiplexing and short library preparation, for HLA genotyping from ...
(Date:1/27/2020)... ... January 27, 2020 , ... Valencell, the leading ... strategic investors led by Halma plc , a FTSE 100 global group ... GII LLC, and WSJ Joshua Fund. A representative from Halma will join the ...
(Date:1/22/2020)... (PRWEB) , ... January 20, 2020 , ... ... announced a partnership with WAVE Electronics, the largest independent electronics distributor in the ... to purchase Brilliant Smart Home Systems with leading smart home products from a ...
(Date:1/10/2020)... ... January 09, 2020 , ... ... today announced the acquisition of Cunesoft, a move that expands the company’s portfolio ... of life sciences companies. , Based in Munich, Germany, Cunesoft provides intelligent software ...
Breaking Biology Technology:
Cached News: