HOME >> BIOLOGY >> NEWS
Leukemia stem cells identified by Stanford researchers

STANFORD, Calif. A handful of leukemia cells constantly replenish the supply of cancerous cells, according to new work by Stanford University School of Medicine researchers. These self-renewing cells, called cancer stem cells, are the ones chemotherapy must wipe out in order to eliminate the disease. Treatments that destroy these cells could more effectively eliminate cancer.

Current treatments destroy cancer cells indiscriminately, draining the reservoir of cancer cells without specifically eliminating the cancer's source. "We were missing the boat because we were targeting the wrong cell," said Catriona Jamieson, MD, PhD, instructor in hematology and first author of the paper.

Other researchers have found cancer stem cells in acute myelogenous leukemia, breast cancer and two types of brain cancer. The current work, published in the Aug. 12 New England Journal of Medicine, is the first to describe these cells in chronic myelogenous leukemia. This is also the first time researchers have identified which cell becomes cancerous, transforming from a normal healthy cell to a cancer stem cell.

Jamieson and her team working with Irving Weissman, MD, the Karel H. and Avice N. Beekjuis Professor in Cancer Biology, and hematology colleagues at Stanford, the University of Toronto and UCLA, found the cells through careful detective work. She separated the cancerous cells into subgroups, each with a characteristic pattern of proteins on their cell surface. She then put each of these populations on a separate lab dish to see which could renew their population. In the end, only one group of cells had the ability to self-renew, constantly dividing to produce both new stem cells and cells that matured.

Jamieson examined these cancer stem cells and found they resembled normal cells in the blood called granulocyte/macrophage progenitor cells. This finding came as a surprise. Researchers had thought that the cancer stem cells came from normal st
'"/>


11-Aug-2004


Page: 1 2 3

Related biology news :

1. Newly Discovered Viral Gateway Into Cells Could Play Role In Diagnosis And Treatment Of Leukemia, HIV And Other Viral Diseases
2. Chromosomal Abnormalities Key For Prediting Leukemia Outcome
3. Hormone Control Of Rare Leukemia Sheds Light On Molecular Basis Of Cancer
4. New Gene Alteration Find Points To Aggressive Leukemia Treatment
5. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
6. Researchers develop fast track way to discover how cells are regulated
7. Chemical signals health of brain cells Symposium
8. New dye directly reveals activated proteins in living cells
9. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
10. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
11. Smac-ing back at cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 13, 2019 , ... Join Anguraj Sadanandam, ... Institute of Cancer Research (ICR) in a live webinar on Wednesday, ... of biomarker and companion diagnostic development including machine learning approaches in different gastrointestinal ...
(Date:8/9/2019)... ARLINGTON, Va. (PRWEB) , ... August 09, 2019 , ... ... options for patients, more and more patients will visit urgent care centers (UCC) in ... firm Kalorama Information. The report, The Market for Urgent Care Centers , is ...
(Date:8/6/2019)... ... August 06, 2019 , ... VetStem ... clinical, regulatory and GMP manufacturing experience. In November it spun out a ... extensive regulatory experience and one of the first cGMP cell manufacturing facilities ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... Pa. (PRWEB) , ... August 13, 2019 , ... ... nuclear receptor and in vitro toxicology testing solutions, announced the appointment of Mark ... industry experience to the Board. , Mark McLoughlin will lend his healthcare expertise ...
(Date:8/7/2019)... ... ... Locus Agricultural Solutions (Locus AG) reports record levels of carbon sequestered in ... ® , which is pulling up to 121% more carbon into the soil than ... from the treatment of almonds, cherries, turf/sod, grapes and citrus across the U.S., as ...
(Date:8/6/2019)... DEERFIELD, Ill. (PRWEB) , ... August 05, 2019 ... ... announced that Jason Casarella has been recognized as a distinguished leader by PharmaVOICE ... is featured in an article in the magazine’s July/August special issue. , As ...
(Date:7/30/2019)... , ... July 30, 2019 , ... ... premiere team building and cooking events company. Not only has the company already ... also started offering Private Cooking Parties to its guests. , With Lajollacooks4u’s Private ...
Breaking Biology Technology:
Cached News: