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Leukemia stem cells identified by Stanford researchers

is inappropriately activated is also susceptible to breast cancer. He said that many proteins in addition to beta-catenin are involved in the Wnt pathway, any one of which might activate the pathway and trigger self-renewal.

One goal of Weissman's lab is to identify cancer stem cells in a broad range of cancer types to learn more about which proteins go awry in these cells. Eventually, he said this work could lead to new drugs that shut down these inappropriately active proteins. "When drugs that inhibit those targets become available, combination therapy might have a chance of really working," Weissman said.


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11-Aug-2004


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