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'Library on a Slide': Whole genome microarrays for comparative genomics

ed the hemolysin gene a known virulence factor. The results from the array experiment matched perfectly with results from experiments using dot blot and Southern hybridisation methods.

The researchers can envisage other ways that their technique could develop: "A single 'Library on a Slide' could also be constructed with isolates from several related species, or species that are part of a microbial ecosystem. Such a platform would enable us to examine the extent of shared genetic elements across species especially horizontally transferred virulence factors and antibiotic resistance genes."


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BioMed Central
21-Mar-2004


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