HOME >> BIOLOGY >> NEWS
Link Made Between Human Growth Hormone, Bone Quality In Mice

EDITORS: A black-and-white slide comparing magnified cross-sections of bone in experimental and control mice is available on request.

ANN ARBOR---Laboratory mice which have been genetically altered to produce human growth hormone grow to be 25-30 percent larger than normal mice---with much of that size difference coming from bigger bones, according to University of Michigan researchers. The trade-off for bigger bones in adolescence, however, appears to be poorer bone quality, increased brittleness and less resistance to fractures as mice age.

Steven A. Goldstein, professor of surgery in the U-M Medical School and professor of biomedical engineering in the U-M College of Engineering, suggested his results, while preliminary, raise a "red flag" on the increasing use of human growth hormone in short children and as a "fountain-of-youth drug" in the elderly.

The study by Kuo-Fung Tseng, now with the Veterans General Hospital in Taipei, Taiwan, and Goldstein is published in the April 1998 issue of the Journal of Bone and Mineral Research.

The U-M study was designed to learn more about complex feedback mechanisms between genes and mechanical forces, which control how bones grow and develop. "This balance between structure and function has evolved over years of mammalian evolutionary development to produce bone strong enough for an animal's daily activity, but not so strong that it requires too much energy to grow and maintain," Goldstein said. "Disturbances in this well-balanced relationship could result in bone fragility diseases, such as osteoporosis."

Thirty-nine of the male mice in the U-M study were transgenic---meaning that their DNA contained both mouse and human genes. These mice were able to secrete large amounts of human growth factor, because the human gene which triggers production of this hormone had been inserted into their DNA during the fertilized egg stage of de
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
(734) 647-1844
University of Michigan
30-Mar-1998


Page: 1 2 3

Related biology news :

1. UB Study Finds No Relationship Between Male Consumption Of Lake Ontario Fish And Conception Delay
2. Jefferson Scientists Find Link Between Learning And Preventing Alzheimers
3. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer
4. Scientists Devise Method To Address Conflict Between Molecular Clock, Fossil Record Of Mammalian Evolution
5. Autoimmune Diseases Study Shows Differences Between Men And Women
6. A Fresh Look At Love And War Between The Sexes
7. Real Connection Between Oral Health And Heart Disease
8. Gap Widening Between Genetic And Behavioral Research
9. Flexible Membranes - Moving Through The Twilight Zone Between The Nano- And The Microworld
10. UCSF Study Finds No Association Between Hair Dye And Non-Hodgkin Lymphoma
11. Penn Researchers Awarded $10 Million Grant To Study Link Between Genes And Hormone-Related Cancers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... Md. (PRWEB) , ... July ... ... Molecular Biology Systems, B.V. (MBS) has announced a publication detailing the use ... one-step reverse transcription polymerase chain reaction (RT-PCR) in 16 minutes. The article, ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a ... most common and aggressive adult brain cancer—announced today the appointments of its first ... charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows are ...
(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode scheduled for ... Point of Care Testing solutions (POCT). Check local listings for more info. , Today, ... offices and are shipped to labs throughout the country. Results are then available several ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 08, 2020 , ... Bode ... significant expansion of laboratory operations through its COVID-19 testing service, Bode-CARES . ... , Bode-CARES provides a turnkey solution that includes a comprehensive ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its Chief ... clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as an ...
(Date:7/1/2020)... , ... June 29, 2020 , ... ... to date growth of 40% in 2020, despite many obstacles created as a ... aims to increase revenue for its partnered medical practices and medical manufacturers by ...
(Date:6/28/2020)... LAGUNA NIGUEL, Calif. (PRWEB) , ... June 25, 2020 , ... ... today announced the launch of Safe Space™ for businesses of all types to ensure ... and 3D LiDAR. , A Safe Space™ enabled business will provide a ...
Breaking Biology Technology:
Cached News: