HOME >> BIOLOGY >> NEWS
Link between alcohol consumption and muscle damage in females

December 1, 2003 (Bethesda, MD) A common manifestation of alcoholism is the degeneration, or wasting away, of skeletal muscle. The condition, known as alcoholic myopathy, affects up to two-thirds of those who excessively consume alcohol; moreover, women appear to be particularly susceptible. The dominant features of this disorder are cramps, impaired muscle strength, and reduced whole body lean tissue mass, all of which are accompanied by reductions in the relative amounts of specific contractile proteins within the muscle itself.

Although there is also some evidence to suggest that malnutrition exacerbates the effects of alcohol on muscle, the mechanisms responsible for myopathy remain elusive. Some studies suggest that acetaldehyde (a toxic intermediate compound formed by the action of alcohol dehydrogenase enzyme during the metabolism of alcohol), rather than alcohol, is the principal pathogenic perturbant.

A New Study
In an attempt to better understand the pathology induced by alcohol on a common muscle, a team of researchers has tested their hypotheses to determine if: (1) increases in c-myc mRNA levels also occur in the muscle of rats chronically exposed to alcohol, (2) muscle of female rats is more sensitive than muscle in their male counterparts, (3) raising acetaldehyde also increases c-myc, (4) prior starvation causes further increases in c-myc mRNA expression in response to ethanol, and (5) other genes involved in apoptosis (i.e., p53 and Bcl-2) are also affected by alcohol.

The researchers are Tatsuo Nakahara, of the Department of Chemistry, Kyushu University, Ropponmatsu, Fukuoka; Kijiro Hashimoto and Makoto Hirano, both from the Center for Emotional and Behavioural Disorders, Hizen National Mental Hospital, Kanzaki, Saga, Japan; Michael Koll and Victor R. Preedy, from the Department of Nutrition and Dietetics, and the Genomics Centre, respectively, King's College London, London, England; and Colin R. Martin, fro
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
3-Dec-2003


Page: 1 2 3 4

Related biology news :

1. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
2. New research suggests link between maternal diet and childhood leukemia risk
3. Fossils reveal direct link between global warming and genetic diversity in wildlife
4. Battle between bubbles might have started evolution
5. UCSD researchers are first to demonstrate molecular link between inflammation and cancer
6. New survey reveals insights into unique relationship between mothers and pediatricians
7. Study explains spatial orientation differences between sexes
8. New technique helps scientists reveal interactions between genes and drugs
9. Unique partnership between UH, FDA opens path for scientific exchange
10. Study supports association between HPV infection and head and neck cancer
11. OneWorld Health CEO outlines mutually beneficial collaborations between industry, nonprofits at BIO

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/16/2019)... ... April 16, 2019 , ... The Healthcare Technology Report is ... An extensive process was run to evaluate the hundreds of CEOs that lead ... and other related areas. We gathered data on each nominee’s professional background and ...
(Date:4/12/2019)... ... 2019 , ... Neal O’Farrell is one of the first generation of security ... director of the consumer advocacy non-profit the Identity Theft Council as well as Schooled ... Federal Communications Commission’s Cybersecurity Roundtable and is currently a fellow of the EP3 foundation. ...
(Date:4/12/2019)... ... April 12, 2019 , ... ... products from complex microbiota accessible carbohydrates (MACs) as specialty ingredients for the global ... Feed Materials Register and commercial launch of its first-in class microbiome modulating prebiotic ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... , ... April 09, 2019 , ... ... the innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious ... antibody repertoires is part of CZ Biohub’s efforts to establish new approaches to ...
(Date:3/27/2019)... ... March 26, 2019 , ... A leader in the field of ... veterinarians across the United States and Canada since 2004. The primary indications for ... injuries in the dog, cat, and horse. Recently, VetStem teamed up with ...
(Date:3/23/2019)... ... March 22, 2019 , ... ... LenS3 Multi-Angle Light Scattering (MALS) detector , offering a revolutionary approach for the ... polysaccharides, proteins, and biopolymers. A novel optical design, a unique cell-block assembly, and ...
(Date:3/19/2019)... ... 19, 2019 , ... Konica Minolta Precision Medicine, Inc. (KMPM), ... their inaugural Scientific Advisory Board. , Founded in late 2018, KMPM ... variability in genes, environment, and lifestyle to more accurately predict, detect, treat and ...
Breaking Biology Technology:
Cached News: