HOME >> BIOLOGY >> NEWS
Little-known substance regulates inflammatory response

In the September 29 issue of the journal Science, researchers from the University of Chicago show that a little-known molecule called A20 plays a critical role in regulating inflammation. This unexpected finding suggests an entirely new target for drugs designed to treat inflammatory diseases such as ulcerative colitis, Crohn's disease, rheumatoid arthritis and even septic shock.

First discovered ten years ago, A20 was largely ignored as an insignificant link in the chain reaction of inflammation. Scientists thought it was only produced by certain types of white blood cells in a few tissues such as the intestines and thymus.

"A20 had been studied in only a limited way at the cellular level and never in a live animal," said Averil Ma, M.D., assistant professor of medicine and immunology at the University of Chicago, who uses transgenic mice to study the basic biology of inflammatory bowel disease.

"We created mice that lacked the A20 gene, hoping to identify its function in intestinal lymphocytes," he said. Instead they discovered that the molecule was much more widespread than anticipated and that it was a critical regulator of inflammation in multiple tissues.

"We found that rapid expression of A20," said Ma, "was absolutely essential for down-regulating the inflammatory response and averting the damage unrestrained inflammation can cause in multiple tissues."

Within three to six weeks after birth, mice without the gene for A20 spontaneously developed severe inflammation and tissue damage in multiple organs. When exposed to substances that mimic infection or trigger inflammation, mice lacking A20 developed symptoms identical to septic shock -- plummeting blood pressure, widespread inflammation, kidney damage, decreased heart function -- and died within two hours. In contrast, normal mice with A20 had no symptoms despite exposure to ten-fold higher doses of these same stimulants.

Inflammation is part of the normal response
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
28-Sep-2000


Page: 1 2 3

Related biology news :

1. Antimalarial substances found in New Caledonian sponges
2. Sponge substance works well with yew derivative to thwart cancer cell proliferation
3. Common airborne substance makes asthmatics more sensitive to house dust mites: study
4. SCOPE/IUPAC report on endocrine active substances to be published
5. IUPAC report- Natural and synthetic substances
6. Mosquitoes repelled by tomato-based substance
7. A genetic risk factor for substance abuse
8. Stratified seawater disrupts the transport of imposex substances
9. UC Riverside scientists discover wound-healing substance
10. Fred Hutchinson Cancer Research Center, University of Washington join in national effort to study health impact of toxic substances
11. Vitamin-like substance leads to dramatic improvements in patients with muscular disorder

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., ... a Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. ... best practices and how Proscia improves lab economics and realizes an increase in ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 /PRNewswire/ ... London (ICR) and University of ... tool to risk-stratify patients with multiple myeloma (MM), in a ... . The University of Leeds is ... Myeloma UK, and ICR will perform the testing services to ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
Breaking Biology Technology:
Cached News: